Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

Oršolić, Nada; Car, Nikola; Lisičić, Duje; Benković, Vesna; Knežević, Anica Horvat; Đikić, Domagoj; Petrik, József

doi:10.1002/jps.23755

Cited by 20 publications

(33 citation statements)

References 49 publications

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“…Oršolić et al [ 68 ] administered propolis (50 mg/kg, ip) 7 and 3 days before inoculation of the Ehrlich ascites tumor (EAT) cells (2 × 10 6 , ip) in mice, and then applied the cisplatin (5 or 10 mg/kg, ip) 3 days after the inoculation of EAT cells at 37 °C and 43 °C. After the experimental period, they reported that the combination of propolis + cisplatin 5 mg/kg at 37 °C resulted in tumor growth inhibition and increased the survival of mice; propolis also reduced the toxic and genotoxic effect of cisplatin on normal cells without affecting the cytotoxicity of cisplatin on EAT cells.…”

Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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This study was performed to determine the effects of chitosan-coated nano-propolis (NP), which is synthesized via a green sonochemical method, and propolis on the side effects of cisplatin (CP), which is a widely used drug in the treatment of cancer. For this aim, 56 rats were divided into seven groups, balancing their body weights (BW). The study was designed as Control, CP (3 mg/kg BW at single dose of CP as intraperitoneal, ip), Propolis (100 mg/kg BW per day of propolis by gavage), NP-10 (10 mg/kg BW of NP per day by gavage), CP + Propolis (3 mg/kg BW of CP and 100 mg/kg BW of propolis), CP + NP-10 (3 mg/kg CP and 10 mg/kg BW of NP), and CP + NP-30 (3 mg/kg BW of CP and 30 mg/kg BW of NP). Propolis and NP (especially NP-30) were preserved via biochemical parameters, oxidative stress, and activation of apoptotic pathways (anti-apoptotic protein: Bcl-2 and pro-apoptotic protein: Bax) in liver and kidney tissues in the toxicity induced by CP. The NP were more effective than propolis at a dose of 30 mg/kg BW and had the potential to ameliorate CP’s negative effects while overcoming serious side effects such as liver and kidney damage.

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Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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“…Group 4 was given 20 mg/kg indole-3-carbinol orally once daily for 10 days. The dose of cisplatin was selected according to previous studies 36 37 . Longest and shortest diameters of the tumor were measured using a digital Vernier caliper.…”

Section: Methodsmentioning

confidence: 99%

Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1

El-Naga

Mahran

2016

Sci Rep

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Nephrotoxicity associated with the clinical use of the anticancer drug cisplatin is a limiting problem. Thus, searching for new protective measures is required. Indole-3-carbinol is a powerful anti-oxidant, anti-inflammatory and anti-tumor agent. The present study aimed to investigate the potential protective effect of indole-3-carbinol against cisplatin-induced acute nephrotoxicity in rats. Rats were pre-treated with 20 mg/kg indole-3-carbinol orally before giving cisplatin (7 mg/kg). Cisplatin-induced acute nephrotoxicity was demonstrated where relative kidney weight, BUN and serum creatinine were significantly increased. Increased oxidative stress was evident in cisplatin group where GSH and SOD tissue levels were significantly depleted. Also, lipid peroxidation and NOX-1 were increased as compared to the control. Additionally, renal expression of pro-inflammatory mediators was induced by cisplatin. Cisplatin-induced cell death was shown by increased caspase-3 and decreased expression of EGF, IGF-1 and IGF-1 receptor. Nephrotoxicity, oxidative stress, inflammation and apoptotic effects induced by cisplatin were significantly ameliorated by indole-3-carbinol pre-treatment. Besides, the role of CGRP in cisplatin-induced nephrotoxicity was explored. Furthermore, cisplatin cytotoxic activity was significantly enhanced by indole-3-carbinol pre-treatment in vitro. In conclusion, indole-3-carbinol provides protection against cisplatin-induced nephrotoxicity. Also, reduced expression of CGRP may play a role in the pathogenesis of cisplatin-induced renal injury.

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“…The anticarcinogenic activity of the flavonoids in propolis can suppress tumor growth by inhibiting angiogenesis and inducing apoptosis of tumor cells (Szliszka et al, 2011). The protective effect of propolis against several types of cancer, including lung cancer, may occur by directly inhibiting tumor cell growth and inducing apoptosis (Valente et al, 2011) or indirectly by scavenging ROS and increasing antioxidant enzyme activities (Oršolić et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

Brihoum

Maiza

Sahali

et al. 2018

Braz. J. Pharm. Sci.

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The purpose of our study was to divulge the antiproliferative effect of an ethanolic extract of Algerian propolis (EEP) in the human lung adenocarcinoma cell line (A549) and reveal the chemopreventive role against benzo(a)pyrene-induced lung carcinogenesis in albino Wistar rats. Cytotoxicity of EEP was evaluated using the MTT assay and cell adhesion in A549 cells. Moreover, rats were given 25 mg/kg of propolis for 5 days before induction of experimental lung cancer by a single intraperitoneal dose of 200 mg/kg benzo(a)pyrene. Body weight, lung weight, lipid peroxidation, marker enzymes, and enzymatic and non-enzymatic antioxidants were estimated. The EEP demonstrated an inhibitory effect on proliferation of A549 at 24 and 72 hours in a dose-dependent manner and blocked adhesion of the cells by fibrinogen. Moreover, EEP reduced the oxidative stress generated by benzo(a)pyrene. The pre-treatment showed that enzymatic and non-enzymatic antioxidants increased and lipid peroxidation decreased. A histological analysis further supported these findings and showed a decrease in the number of side effects. These results are particularly important for both clinical applications of propolis and the possibility for its use as a potential chemotherapeutic agent.

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Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

Cited by 20 publications

References 49 publications

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

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