Antimicrobial and Antioxidant Activities of Some Plant Extracts

Scio, Elita; Mendes, Rita; Motta, E.V.S.; Bellozi, Paula Maria Quaglio; Aragão, Danielle M.O.; Mello, Josiane Maria Muneron de; Fabri, Rodrigo Luiz; Moreira, Jussara R.; Assis, Isabel V.L. de; Bouzada, Maria Lúcia M.

doi:10.5772/27308

Cited by 18 publications

(15 citation statements)

References 49 publications

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“…Compounds extracted from various members of this genus show bioactive properties (Cruz and Kaplan, 2004). Antibacterial (Mosquera et al, 2009;Scio et al, 2009;dos Santos et al, 2012), antifungal (Niño et al, 2003;Kuster et al, 2009), anti-oxidant (Mosquera et al, 2009;Scio et al, 2009;Sirat et al, 2010), anticancer (Jones et al, 1981) and anti-parasitic activities (Singha et al, 1992;Mpalantinos et al, 1998;Cunha et al, 2009) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Anti-Leishmanial, Anti-Inflammatory and Antimicrobial Activities of Phenolic Derivatives fromTibouchina paratropica

et al. 2014

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A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and compound 1 displayed potent anti-parasitic activity against Leishmania donovani (IC50 = 0.809 µg/mL). In addition, an 85% reduction in the secretion of the pro-inflammatory cytokine IL-6 was recorded when macrophages challenged with lipopolysaccharide were exposed to compound 1, but no effect on the anti-inflammatory IL-10 was observed. Compound 2 showed neither anti-parasitic nor anti-inflammatory properties. In addition, no cytotoxic activities were observed against the human-derived macrophage THP-1 cells.

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Section: Introductionmentioning

confidence: 99%

Anti-Leishmanial, Anti-Inflammatory and Antimicrobial Activities of Phenolic Derivatives fromTibouchina paratropica

et al. 2014

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“…Phytochemical screening of most of the extracts assayed in this study was previously reported and a variety of secondary metabolites was related to these extracts such as alkaloids, triterpens, sterols, tannins, saponins and flavonoids (Scio et al 2012). In this work, among the extracts assayed, Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed strong leishmanicidal activity, exhibiting IC 50 values below of 20 µg/mL, for at least one species of Leishmania.…”

Section: Resultsmentioning

confidence: 83%

“…In this work, among the extracts assayed, Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed strong leishmanicidal activity, exhibiting IC 50 values below of 20 µg/mL, for at least one species of Leishmania. Biological activity of C. sylvestris, P. macropoda and S. tubulosa could be due to the presence of secondary metabolites such as alkaloids, sterols, tannins and flavonoids (Scio et al 2012). C. sylvestris showed remarkable activity against promastigotes of all Leishmania species, with IC 50 below 10 µg/ mL, being more effective than the reference drug miltefosine (Table II), which is currently the only oral drug available for the treatment of visceral leishmaniasis (De Morais-Teixeira et al 2011).…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris

Antinarelli

Pinto

Scio

et al. 2015

An. Acad. Bras. Ciênc.

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Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC 50 values below of 20 µg/mL against at least one species of Leishmania. Casearia sylvestris showed the most expressive activity against all promastigote forms of Leishmania species (IC 50 values of 5.4 µg/mL, 5.0 µg/mL, 8.5 µg/mL and 7.7 µg/ mL for L. amazonensis, L. braziliensis, L. chagasi and L. major, respectively), being more effective than the reference drug miltefosine. In spite of the cytotoxic effect on macrophages (CC 50 value of 5.2 µg/mL), C. sylvestris exhibited a strong inhibition against intracellular amastigotes of L. braziliensis (IC 50 value of 1.3 µg/ mL). Further studies, including bio-guided fractionation will be conducted to identify the active compounds.

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“…10 Plants with antimicrobial activity are characterized by high phenolic and flavonoid content and consequently the high antioxidant activity which could be the basis for this antimicrobial activity. 27 There were variations in the polyphenol content in plants from the same genus (Acacia spp.) which could be due to intrinsic genetic species differences or differences in environmental factors, time of collection and/or storage conditions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Nine Plants Used Medicinally by the Ilkisonko Maasai Community of Kenya

Kimondo

Mutai

Njogu

et al. 2019

FRA

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Objectives: Many plants used in ethnomedicinal interventions have anti-inflammatory, antibacterial, antiviral, anti-aging and anticancer activities attributed to their antioxidant properties. The antioxidant properties may be attributed to high polyphenol content of the plants. The Ilkisonko Maasai are a pastoralist community from Kenya known to ingest certain select plant decoctions for prevention or treatment of targeted illnesses. This study evaluated the antioxidant properties of organic and aqueous extracts of these select plants. Methods: The antioxidant potential was evaluated by 1, 1-diphenyl-2-picrylhydrazyl free radical (DPPH) scavenging method. Total phenolic and flavonoid content were determined using the Folin-Ciocalteu's assay and aluminium chloride colorimetric test, respectively. Results: The organic extracts had significantly higher phenolic and flavonoid content than the aqueous extracts except for Pappea capensis in which the converse was observed. Among the studied plant extracts, Acacia nilotica had the highest phenolic content in the methanol and water extracts (237.26±1.83 mg and 149.66±0.60 mg tannic acid equivalent/g of extract) and the highest antioxidant activity in both the methanol and water extracts with an IC 50 of 54.61µg/mL and 102.96µg/mL, respectively. The standard, ascorbic acid, had an IC 50 of 50.32µg/mL. In both the methanol and water extracts, Acacia reficiens had the highest flavonoid content (130.62±1.78 and 99.80±1.73 mg catechin equivalents/g of extract, respectively). The correlation between the total phenolic content and antioxidant activity was statistically significant (Pearson's r=-0.841). Conclusion: This study found that select plants used by the Ilkisonko Maasai as medicinal plants exhibited high phenolic content and antioxidant activity, giving credence to their ethnomedicinal use.

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Antimicrobial and Antioxidant Activities of Some Plant Extracts

Cited by 18 publications

References 49 publications

Anti-Leishmanial, Anti-Inflammatory and Antimicrobial Activities of Phenolic Derivatives fromTibouchina paratropica

Anti-Leishmanial, Anti-Inflammatory and Antimicrobial Activities of Phenolic Derivatives fromTibouchina paratropica

Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris

Evaluation of the Antioxidant Activity of Nine Plants Used Medicinally by the Ilkisonko Maasai Community of Kenya

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