Anti-Leishmanial, Anti-Inflammatory and Antimicrobial Activities of Phenolic Derivatives from<i>Tibouchina paratropica</i>

Tracanna, María I.; Fortuna, Antonio M.; Cárdenas, Angel V. Contreras; Marr, Alexandra K.; McMaster, W. Robert; Gómez‐Velasco, Anaximandro; Sánchez‐Arreola, Eugenio; Hernández, Lucina; Bach, Horacio

doi:10.1002/ptr.5263

Cited by 18 publications

(13 citation statements)

References 20 publications

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“…The phytochemical data for C. hirta, C. capitellata and the other extracts were consistent with other studies (Gordon et al, 2011;Abdellaoui et al, 2014;Tracanna et al, 2015;Scalco and Munhoz, 2016). The absence of alkaloids in the extracts confirms this as a chemotaxonomic characteristic of the family Melastomataceae (Silva et al, 2010).…”

Section: Discussionsupporting

confidence: 90%

Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)

Bomfim¹,

Santos²,

Carneiro³

et al. 2020

J. Med. Plants Res.

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The resistance of microorganisms to current antimicrobials, and the deleterious effects caused by the excessive free radical manufacturing in the human body and their relationship with increasing global incidence of cancer, has led to a continuous search for new chemical agents that can contribute to the fight against these ills. The objective of the present work was to evaluate the antimicrobial, antioxidant and cytotoxic activities and determine the chemical profile of ethyl acetate extract of ten species of the family Melastomataceae. Antimicrobial activity was assessed by the methods of disk diffusion in agar and microdilution in broth (MIC-µg/mL). Antioxidant activity was measured by DPPH free radical capture assay while toxicity was evaluated with Artemia salina Leach. Cytoxicity was evaluated by in vitro tests with THP-1-cells. Identification of the classes of metabolites was performed using chemical reagents, while quantification of total phenols (EGA/g) and total flavonoids (EQ/g) was done by spectrophotometry. The extract of Clidemia capitellata exhibited activity against Micrococcus luteus with MIC = 62.5-μg/mL. The extract of C. hirta had the highest sequestering activity of DPPH free radicals (63.54-%). The toxicological assay revealed high toxicity for Miconia alborufescens extract (CL 50 61.6-μg/mL). Cytotoxic activity of extracts for THP-1-cells was observed through visualization of apoptotic bodies and cell death. Phytochemical analysis detected the presence of condensed tannins, terpenes, steroids and polyphenols, and the absence of alkaloids. The assays performed provided promising results, suggesting the continuation of new chemical-pharmacological evaluations and the isolation of the active principle of the extracts.

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Section: Discussionsupporting

confidence: 90%

Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)

Bomfim¹,

Santos²,

Carneiro³

et al. 2020

J. Med. Plants Res.

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“…However, other species within the genus have been reported to possess various biological activities such as wound healing and to treat cataract. [24] The isolated compounds 9 -11 from our study were found to be present in T. semidecandra L. leaves [12] which possess antioxidant and antityrosinase activities. [12] Furthermore, published data showed that compounds 7 and 8 possess antitumor [17] activities whereas compound 7 was believed to possess high antioxidant activity [17] and plays an important role in the prevention of malignant transformation and cancer development.…”

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confidence: 67%

Flowers in Australia: Phytochemical Studies on the Illawarra Flame Tree and Alstonville

Hendra

Keller

2016

Aust. J. Chem.

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The first reported phytochemical studies on two species of flowers in Australia enabled the identification of six secondary metabolites from Illawarra flame tree flower (Brachychiton acerifolius) and seven secondary metabolites from the flowers of the Alstonville (Tibouchina lepidota). Pelargonidin 3-(6-coumarylglucoside)-5-(6-acetylglucoside) was found to be responsible for the red colour of B. acerifolius, whereas malvidin 3-(coumarylglucoside)-5-(acetylxyloside) was responsible for the purple colour of (T. lepidota) flowers. (2S)-4,5-Dihydroxyflavanone 7-O-β-d-glucuronide methyl ester was isolated for the first time from B. acerifolius, and its absolute configuration was determined by circular dichroism spectroscopy. Some of the traditional uses of B. acerifolius could also be correlated with the known activity of the isolated metabolites. AbstractThe first reported phytochemical studies into two species of flowers in Australia resulted in the identification of six secondary metabolites from Illawarra flame tree flower (Brachychiton acerifolius) and seven from the flowers of the Alstonville (Tibouchina lepidota). Pelargonidin 3-(6-coumarylglucoside)-5-(6-acetyl-glucoside) was found to be responsible for the red colour from B. acerifolius while malvidin 3-(coumarylglucoside)-5-(acetylxyloside) for the purple colour from (T. lepidota) flowers. (2S)-4,5-Dihydroxylavanone 7-O-β-D-glucuronide methyl ester was isolated for the first time from B acerifolius and its absolute configuration was determined by circular dichroism spectroscopy. Some of the traditional uses of B. aerifoius could also be correlated to the known activity of the isolated metabolites.Before European settlement of Australia, the indigenous people used plants and flowers for numerous purposes including as nutrients, medicine, and dyes. [1] Australia has over 30,000 described species of vascular plants which grow in a wide range of climatic types encompassed by the continent allowing a diversity of plants and flowers unlike any other country. [2] However, there is limited information available pertaining to the phytochemical studies of Australian flowers.

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“…Few examples of traditional uses are described in the literature for Tibouchina . Among them are anti-inflammatory, antioxidant [18], antinociceptive (relieving chronic pain) [19], antibacterial [20,21], antifungal [22,23], antiparasitic [20,24,25], and anticancer [26] activities of leaf extracts. Nonetheless, the chemical composition of Tibouchina largely remains elusive, with only eleven species being characterised phytochemically.…”

Section: Introductionmentioning

confidence: 99%

Acylated Flavonoid Glycosides are the Main Pigments that Determine the Flower Colour of the Brazilian Native Tree Tibouchina pulchra (Cham.) Cogn.

et al. 2019

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Tibouchina pulchra (Cham.) Cogn. is a plant native to Brazil whose genus and family (Melastomataceae) are poorly studied with regards to its metabolite profile. Phenolic pigments of pink flowers were studied by ultra-performance liquid chromatography with a photodiode array detector and electrospray ionization quadrupole time-of-flight mass spectrometry. Therein, twenty-three flavonoids were identified with eight flavonols isolated by preparative high-performance liquid chromatography and analysed by one- and two-dimensional nuclear magnetic resonance. Kaempferol derivatives were the main flavonols, encompassing almost half of the detected compounds with different substitution patterns, such as glucoside, pentosides, galloyl-glucoside, p-coumaroyl-glucoside, and glucuronide. Concerning the anthocyanins, petunidin p-coumaroyl-hexoside acetylpentoside and malvidin p-coumaroyl-hexoside acetylpentoside were identified and agreed with previous reports on acylated anthocyanins from Melastomataceae. A new kaempferol glucoside was identified as kaempferol-(2′′-O-methyl)-4′-O-α-d-glucopyranoside. Moreover, twelve compounds were described for the first time in the genus with five being new to the family, contributing to the chemical characterisation of these taxa.

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Anti-Leishmanial, Anti-Inflammatory and Antimicrobial Activities of Phenolic Derivatives fromTibouchina paratropica

Cited by 18 publications

References 20 publications

Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)

Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)

Flowers in Australia: Phytochemical Studies on the Illawarra Flame Tree and Alstonville

Acylated Flavonoid Glycosides are the Main Pigments that Determine the Flower Colour of the Brazilian Native Tree Tibouchina pulchra (Cham.) Cogn.

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