Antimicrobial and anticancer activities of cobalt (III)-hydrazone complexes: Solubilities and chemical potentials of transfer in different organic co-solvent-water mixtures

Mohamad, Ahmad Desoky M.; Abualreish, M. J. A.; Abu‐Dief, Ahmed M.

doi:10.1016/j.molliq.2019.111162

Cited by 70 publications

(28 citation statements)

References 57 publications

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“…After 48 h, cells were rinsed and treated with SRB (sulforhodamine B), the protein-binding dye. [30][31][32][33] Excrescent stain was washed using acetic acid, whereas the linked stain was retrieved using Tr-EDTA buffer. Color intensity was measured using an ELA reader.…”

Section: In Vitro Anticancer Activitymentioning

confidence: 99%

Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles

Alothman

Ammar

2020

Applied Organom Chemis

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In the search of effective bioactive compounds, Co(II) (C1) and Cd(II) (C2) complexes of the type [M(FMAPIMP)(H2O)Cl].nH2O (where M = Co(II); n = 2, Cd(II); n = 3, and FMAPIMP = ligand[2‐((E)‐((2‐(((E)‐furan‐2‐ylmethylene)amino)phenyl)imino)methyl)phenol]) were synthesized and characterized using elemental analysis, UV–Vis., cyclic voltammetry, Fourier‐transform infrared (FT‐IR), nuclear magnetic resonance, and mass spectral studies. The thermal stability of nano‐sized Co(II) and Cd(II) complexes was studied using thermogravimetric analysis (TGA). Cobalt and cadmium oxides were synthesized using cobalt and cadmium nanoparticle (NP) structure Schiff base complexes as the raw material after calcination for 5 h at 600 °C. According to the results, Co(II) and Cd(II) complexes with mole ratio 1:1 of metal: H‐FMAPIMP which octahedral are the most probable geometry for it. On the contrary, synthesized C1 and C2 NPs were used as suitable precursors for the preparation of CoO and CdO NPs. The obtained NPs were characterized using FT‐IR, UV–Vis., TGA, powder X‐ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy techniques. PXRD analysis revealed that the obtained oxides were crystalline and corresponded to CoO and CdO phases. Crystal size, shape, and morphology were determined using SEM and TEM. H‐FMAPIMP and its two complexes (C1 and C2) were tested against human ovarian cancer cell line (PA‐1). The synthesized Co(II) and Cd(II) complexes exhibited enhanced activity against the tested bacterial (Staphylococcus aureus and Escherichia Coli) and fungal strains (Candida albicans and Aspergillus fumigatus) as compared to H‐FMAPIMP. The results of the DNA‐cleavage activity indicated that the ligand and its two complexes can cleave calf thymus‐DNA at different degrees. Further, antituberculosis activity was performed using microplate alamarBlue assay. Among all these synthesized compounds, C1 exhibited good cleaving ability compared to the newly synthesized C2. Finally, the geometry of H‐FMAPIMP and its Co(II) and Cd(II) complexes was optimized using molecular modeling.

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Section: In Vitro Anticancer Activitymentioning

confidence: 99%

Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles

Alothman

Ammar

2020

Applied Organom Chemis

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“…These cells were placed on a 96-multi-well dish (10 4 cells/well) for 24 h prior to their treatment with the compounds of interest in order to allow the attachment of cells to the wall of the plate. For each individual dose, different concentrations (10,20,25,30, and 50 μg/mL) of the tested compounds were added onto the anticancer cell monolayer. The incubation of the monolayer cell with the compounds was performed at 37 C in 5% CO 2 atmosphere for 48 h, after which cells were rinsed and stained with Sulfo-Rhodamine-B, the protein-binding dye.…”

Section: In Vitro Anticancer Activitymentioning

confidence: 99%

“…The incubation of the monolayer cell with the compounds was performed at 37 C in 5% CO 2 atmosphere for 48 h, after which cells were rinsed and stained with Sulfo-Rhodamine-B, the protein-binding dye. [28][29][30][31] Excess stain was removed by washing with acetic acid, whereas linked stain was retrieved using Tris-ethylenediaminetetraacetic acid buffer. Color intensity was measured using an ELISA reader.…”

Section: In Vitro Anticancer Activitymentioning

confidence: 99%

Nano‐sized Cu(II) and Zn(II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA‐binding/cleavage, anticancer, and antimicrobial activities

Alothman

2020

Applied Organom Chemis

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Two new divalent copper (C1) and zinc (C2) chelates having the formulae [M(PIMC)2] (where M = Cu(II), Zn(II) and PIMC = Ligand [(E)‐3‐(((3‐hydroxypyridin‐2‐yl)imino)methyl)‐4H‐chromen‐4‐one] were obtained and characterized by several techniques. Structures and geometries of the synthesized complexes were judged based on the results of alternative analytical and spectral tools supporting the proposed formulae. IR spectral data confirmed the coordination of the ligands to the copper and zinc centers as monobasic tridentate in the enol form. Thermal analysis, UV‐Vis spectra and magnetic moment confirmed the geometry around the copper center to be tetrahedral, square pyramidal and octahedral. Study of the binding ability of the synthesized compounds with Circulating tumor DNA (CT‐DNA) bas been evaluated applying UV‐Vis spectral titration and viscosity measurements. The copper and zinc oxides were achieved from the copper and zinc nano‐particles structures Schiff base complexes as the raw material after calcination for 5 hr at 600°C. On the other hand, synthesized of C1 and C2 NPs were used as suitable precursors to the preparation of CuO and ZnO NPs. Finally, the synthesized of the two complexes exhibited enhanced activity against the tested bacterial (Staphylococcus aureus and Escherichia Coli) and fungal strains (Candida albicans and Aspergillus fumigatus) as compared to HPIMC. Among all these synthesized compounds, C1 exhibits good cleaving ability compared to other newly synthesized C2.

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“…Cobalt is an essential trace element, apart from being an important part of vitamin B12 form, the presence of cobalt is necessary to play a decisive role in generating neurotransmitters [25][26]. Various Co(III) complexes have been reported with antimicrobial activities [27] and anticancer activities [28]. Co(II) complexes of the Schiffs bases had been reported for their antimicrobial and antifungal properties.…”

Section: Introductionmentioning

confidence: 99%

Preparation, spectral study and antimicrobial activity of binary Co(II) complexes derived from 2’-hydroxy chalcones

Patil¹,

Zangade²

2022

Bull. Chem. Soc. Eth.

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ABSTRACT. The present work comprises preparation, characterization, thermal behavior and growth inhibitory activity of some novel Co(II) complexes derived from substituted (E)-1-(1-hydroxy-4-iodonaphthalen-2-yl)-3-phenylprop-2-en-1-one (L1) and (E)-1-(4-bromo-1-hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-one (L2-L6). Newly synthesized metal-ligand complexes were structurally confirmed with suitable spectroscopic technique such as FT-IR, EPR, NMR (both 1H and 13C). XRD analysis for complex C1 confirmed the crystal system; tetragonal and space group; P 42/n: 2 with unit cell dimensions a, b = 13.3516 Å, c = 10.8009 Å; α, β, γ = 90o. The IR and EPR study demonstrated that interaction between metal ions and ligand occurs through carbonyl oxygen and hydroxyl oxygen. From the values of magnetic moment (μ) it was observed that synthesized complexes (C1-C6) are paramagnetic with three unpaired electrons contain one electron in t2g orbital and two electrons in eg orbitals. Further all these complexes have been evaluated in-vitro for their antimicrobial activity against the Gram positive bacteria Staphylococcus aureus, Gram negative bacteria Escherichia coli and the yeast Candida albicans. The complex C1 showed the significant antimicrobial activity, whereas the complexes C2, C4, C5 and C6 are moderately active against the tested pathogens. The antimicrobial data revealed that growth inhibitory activities of complexes were enhanced comparatively than its respective ligands. The enhanced antimicrobial activity is attributed to the presence of halogens (Br, Cl, I) and hydroxyl (OH) active substituents associated with the basic nucleus of complexes. Therefore, the present study helps to develop a new class of antimicrobial analogues. KEY WORDS: Metal complexes synthesis, 1,3-Diaryl-2-propene-1-one, Crystal structure, Thermal properties, Antimicrobial activity Bull. Chem. Soc. Ethiop. 2021, 35(3), 513-524. DOI: https://dx.doi.org/10.4314/bcse.v35i3.4

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Antimicrobial and anticancer activities of cobalt (III)-hydrazone complexes: Solubilities and chemical potentials of transfer in different organic co-solvent-water mixtures

Cited by 70 publications

References 57 publications

Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles

Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles

Nano‐sized Cu(II) and Zn(II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA‐binding/cleavage, anticancer, and antimicrobial activities

Preparation, spectral study and antimicrobial activity of binary Co(II) complexes derived from 2’-hydroxy chalcones

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