Antimicrobial and antibiofilm activity of polyurethane/Hypericum perforatum extract (PHPE) composite

Nazli, Okay; Baygar, Tuba; Dönmez, Çiğdem Elif Demirci; Dere, Özcan; Uysal, Ali İhsan; Aksozek, Alper; Işık, Ceyhun; Aktürk, Selçuk

doi:10.1016/j.bioorg.2018.08.017

Cited by 25 publications

(15 citation statements)

References 27 publications

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“…Fisher and Phillips 51 demonstrated that Gram-positive bacteria are more susceptible to herbal oils than Gram-negative bacteria due to the lack of a relatively impermeable outer membrane that surrounding gram-negative bacteria. Similar to our results, Nazlı et al 19 reported that the H. perforatum extract incorporated polyurethane membranes were much more effective on S. aerus than E. coli . Güneş and Tıhmınlıoğlu studied H. perforatum incorporated chitosan films and reported that films had an antimicrobial effect on both E. coli and S. aureus .…”

Section: Resultssupporting

confidence: 92%

“…In another study examining the antibiofilm and antimicrobial properties of films formed by the combination of polyurethane and H. perforatum extract, it was found that the S. aureus biofilm was decreased by 92.85 % in the films produced by combining polyurethane and H. perforatum extract compared to the control group. 19 Güneş and Tıhmınlıoğlu has developed a film wound dressing material produced by encapsulating H. perforatum oil in a chitosan matrix using the solvent casting method. 20 Growth inhibition of chitosan films containing different amounts of H. perforatum oil was investigated on E. coli and S. aureus , and the films were found to have antimicrobial effects on both microorganisms.…”

Section: Introductionmentioning

confidence: 99%

“…Although the studies investigating the use of H. perforatum for wound dressing show that H. perforatum incorporated wound dressing materials may be a good antibacterial dressing, they are insufficient to examine their effects on wound healing. 19,20 In the current study, alginate films incorporating H. perforatum extracts were produced as wound dressing materials and investigated their wound healing potential in fibroblast cell culture by using scratch assay and viability assay. In addition, antibacterial activities of these films were evaluated on S. aureus and E. coli bacteria according to the viable cell colony count method (CFU).…”

Section: Introductionmentioning

confidence: 99%

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Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

Mutlu

Erci

Çakır-Koç

2022

Journal of Bioactive and Compatible Polymers

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The incorporation of herbal extracts in wound dressing materials is an important concept that has been researched recently. In this study, alginate films incorporated in the various ratio (0.25–1% v/v) of Hypericum perforatum extract (HPE) for potential applications of wound dressing were successfully prepared by solvent-casting method. The obtained films were examined for cytotoxicity, in vitro wound healing potential, swelling behavior, antioxidant, and antibacterial properties. When compared to the alginate film (Al) alone, HPE incorporated alginate films (HPE/Al) exhibit improved antioxidant properties according to the results of CUPRAC assay and antioxidant activity increases with the rate of HPE. Also, HPE/Al films exhibited antibacterial activity against E. coli and S. aureus, and addition with the HPE extract into films significantly increased the antibacterial activity against S. aureus. All film samples had no cytotoxic effects on fibroblast cell line and HPE/Al films showed a proliferative effect with high extract concentrations (1%) compared to extract free-films. Also, scratch assay results show that films containing 0.5% (v/v) HPE may have a positive effect on wound healing. The results have shown that the newly developed HPE incorporated alginate films are a candidate as antibacterial, and antioxidant wound dressing for use on burn or excision wounds.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

Mutlu

Erci

Çakır-Koç

2022

Journal of Bioactive and Compatible Polymers

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“…(2019) in Salmonella . Especially for polyurethane, some studies have demonstrated its anti-biofilm effect on Salmonella , S. aureus and P. aeruginosa ( Nazli et al., 2019 ; Brasão et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance in the Alternative Lifestyles of Campylobacter jejuni

Rossi

Dumont

Santos

et al. 2021

Front. Cell. Infect. Microbiol.

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Campylobacter jejuni is the main pathogen identified in cases of foodborne gastroenteritis worldwide. Its importance in poultry production and public health is highlighted due to the growing antimicrobial resistance. Our study comparatively investigated the effect of five different classes of antimicrobials on the planktonic and biofilm forms of 35 strains of C. jejuni with high phylogenetic distinction in 30 of them. In the planktonic form, the existence of susceptible strains to colistin (7/35 – 20%) and resistance to meropenem (3/35 – 8.6%) represent a novelty in strains evaluated in Brazil. In biofilms formed with the addition of chicken juice, the number of resistant strains was significantly higher for colistin, erythromycin and meropenem (100%), but the susceptibility to tetracycline was shown as a control strategy for specific cases. High concentrations (1,060 ± 172.1mg/L) of antibiotics were necessary to control the biofilm structure in susceptible strains in the planktonic form, which is consistent with the high biomass produced in these strains. Stainless steel and polyurethane were the most (BFI=2.1) and least (BFI=1.6) favorable surfaces for the production of biomass treated with antimicrobials. It is concluded that the antimicrobial action was detected for all tested drugs in planktonic form. In sessile forms, the biomass production was intensified, except for tetracycline, which showed an antibiofilm effect.

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“…St. John’s Wort has a long tradition of use in the treatment of skin infections. Except for direct inhibitory activity on bacterial growth, H. perforatum has also anti-quorum sensing and anti-biofilm activity [ 177 , 178 , 179 , 180 ]. The wound healing properties and anti-inflammatory action of St. John’s Wort herb, except for hyperforin and hypericin, are related also to flavonoid content (specifically to derivatives of quercetin) [ 43 , 181 , 182 ].…”

Section: Medicinal Plants and Their Constituents With Antibacterial Activity Intended In The Treatment Of Skin Disorders According To Eurmentioning

confidence: 99%

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review

Fialová

Rendeková

Mučaji

et al. 2021

IJMS

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Bacterial infections of skin and wounds may seriously decrease the quality of life and even cause death in some patients. One of the largest concerns in their treatment is the growing antimicrobial resistance of bacterial infectious agents and the spread of resistant strains not only in the hospitals but also in the community. This trend encourages researchers to seek for new effective and safe therapeutical agents. The pharmaceutical industry, focusing mainly on libraries of synthetic compounds as a drug discovery source, is often failing in the battle with bacteria. In contrast, many of the natural compounds, and/or the whole and complex plants extracts, are effective in this field, inactivating the resistant bacterial strains or decreasing their virulence. Natural products act comprehensively; many of them have not only antibacterial, but also anti-inflammatory effects and may support tissue regeneration and wound healing. The European legislative is in the field of natural products medicinal use formed by European Medicines Agency (EMA), based on the scientific work of its Committee on Herbal Medicinal Products (HMPC). HMPC establishes EU monographs covering the therapeutic uses and safe conditions for herbal substances and preparations, mostly based on folk medicine, but including data from scientific research. In this review, the medicinal plants and their active constituents recommended by EMA for skin disorders are discussed in terms of their antibacterial effect. The source of information about these plant products in the review is represented by research articles listed in scientific databases (Science Direct, PubMed, Scopus, Web of Science, etc.) published in recent years.

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Antimicrobial and antibiofilm activity of polyurethane/Hypericum perforatum extract (PHPE) composite

Cited by 25 publications

References 27 publications

Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

Antibiotic Resistance in the Alternative Lifestyles of Campylobacter jejuni

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review

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