Antimicrobial and anti-biofilm activities of bio-inspired nanomaterials for wound healing applications

Arshad, Rabia; Razlansari, Mahtab; Hosseinikhah, Seyedeh Maryam; Tiwari, Aprajita; Ajalli, Narges; Manicum, Amanda-Lee E.; Throat, Nanasaheb D.; Rahdar, Abbas; Zhu, Yangzhi; Tabish, Tanveer A.

doi:10.1016/j.drudis.2023.103673

Cited by 15 publications

(6 citation statements)

References 69 publications

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“…Both topical and systemic treatments are used to aid with wound recovery [ 57 ]. However, local therapy may be preferable since it reduces the risk of complications, boosts efficiency, and helps combat antibiotic resistance [ 58 ]. Studies have shown that many different pharmacological NPs have remarkable effectiveness in promoting skin regeneration, preventing infections, and inhibiting the growth of multidrug-resistant bacteria [ 59 ].…”

Section: Applications Of Different Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Sangnim,

Puri,

Dheer

et al. 2024

Pharmaceutics

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Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain a critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to a prolonged effect. Nanomaterials have emerged as promising candidates in the field of wound healing due to their unique properties and versatile applications. New insights into the interactions between nanomaterials and wound microenvironments have shed light on the mechanisms underlying their therapeutic effects. However, a significantly minimal amount of research has been carried out to see if these nanomaterials significantly promote the wound healing process. In this review, we provided an outline of the various types of nanomaterials that have been studied for healing wounds and infection prevention. Overall, the utilization of nanomaterials in wound healing holds great promise and continues to evolve, providing new opportunities for the development of effective and efficient wound care therapies.

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Section: Applications Of Different Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Sangnim,

Puri,

Dheer

et al. 2024

Pharmaceutics

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“…Therefore, advanced wound dressings which are aimed at meeting the challenge of antibiotic resistance are becoming more popular. 97,98 Advanced nanotechnology-based medicinal dressings have been considered as the best solutions to fight MDR bacteria by targeting specific bacterial colonies. 99 Bai et al have reported that, among the gold/copper/nano bioactive glass nanoparticles, silver nanoparticles showed promising wound healing activity against the MDR microbial strains.…”

Section: Advanced Dressings For Mdr Bacterial Infection Treatmentmentioning

confidence: 99%

“…The authors claim the polymer can be "a candidate for fluid flow controller, artificial skin, wound dressing layer". 97 Chen et al 133 have described the advantages of using a fusion protein of human collagen with elastin-like polypeptides (ELPs). It has better mechanical properties than collagen alone and combines the advantages of collagen and ELP.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

“…These bacteria can worsen the symptoms of immunocompromised patients. Therefore, advanced wound dressings which are aimed at meeting the challenge of antibiotic resistance are becoming more popular. , …”

Section: Wound Healing Dressingsmentioning

confidence: 99%

“…Recently, an elastomer-based hydrogel has been described which combines the advantages of both elastomers and hydrogels. The authors claim the polymer can be “a candidate for fluid flow controller, artificial skin, wound dressing layer” …”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

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Advanced Dressings for Chronic Wound Management

Mishra,

Kushare,

Gupta

et al. 2024

ACS Appl. Bio Mater.

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Wound healing, particularly for chronic wounds, presents a considerable difficulty due to differences in biochemical and cellular processes that occur in different types of wounds. Recent technological breakthroughs have notably advanced the understanding of diagnostic and therapeutic approaches to wound healing. The evolution in wound care has seen a transition from traditional textile dressings to a variety of advanced alternatives, including self-healing hydrogels, hydrofibers, foams, hydrocolloids, environment responsive dressings, growth factor-based therapy, bioengineered skin substitutes, and stem cell and gene therapy. Technological advancements, such as 3D printing and electronic skin (e-skin) therapy, contribute to the customization of wound healing. Despite these advancements, effectively managing chronic wounds remains challenging. This necessitates the development of treatments that consider performance, risk–benefit balance, and cost-effectiveness. This review discusses innovative strategies for the healing of chronic wounds. Incorporating biomarkers into advanced dressings, coupled with corresponding biosensors and drug delivery formulations, enables the theranostic approach to the treatment of chronic wounds. Furthermore, integrating advanced dressings with power sources and user interfaces like near-field communication, radio frequency identification, and Bluetooth enhances real-time monitoring and on-demand drug delivery. It also provides a thorough evaluation of the advantages, patient compliance, costs, and durability of advanced dressings, emphasizing smart formulations and their preparation methods.

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The effect of dexamethasone addition to gentamicin polymeric films of hydroxypropyl methylcellulose/chitosan and hydroxypropyl methylcellulose/polyvinylpyrrolidone

Jaber,

Saadh,

Obeid

2024

Polymer Engineering & Sci

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Many polymeric film formulas containing antibiotics failed in preventing microbial infections due to microbial resistance. One of the main reasons for microbial resistance is the formation of biofilm layers which prevent the drug from reaching the active site. This study aims to evaluate the effect of dexamethasone addition to polymeric film formula containing gentamicin. The polymeric formula containing both dexamethasone and gentamicin were characterized in terms of film's diameters, content uniformity, moisture content, matrix‐drugs association, and drug release. Antibiofilm and antimicrobial activity were used to evaluate polymeric formula containing drug. The addition of dexamethasone to the polymeric formula revealed that most of dexamethasone released and diffused in the first 300 min, while gentamicin release and diffusion had a slower rate like the release of gentamicin from formulations without dexamethasone. The addition of dexamethasone resulted in improved antibiofilm and antibacterial activity with the lowest antibiofilm activity >96% and antibacterial activity >87%. Therefore, dexamethasone addition to polymeric formula containing gentamicin improved the biological activity without any effects on the film characteristics.Highlights Dexamethasone addition to polymeric formula containing gentamicin significantly improved the biological activity. Most of dexamethasone released and diffused in the first 300 min. The addition of dexamethasone resulted in the lowest antibiofilm activity of gentamicin of >96% and antibacterial activity >87%.

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Antimicrobial and anti-biofilm activities of bio-inspired nanomaterials for wound healing applications

Cited by 15 publications

References 69 publications

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Advanced Dressings for Chronic Wound Management

The effect of dexamethasone addition to gentamicin polymeric films of hydroxypropyl methylcellulose/chitosan and hydroxypropyl methylcellulose/polyvinylpyrrolidone

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