Antimicrobial agents

Čapek, A.; Šimek, A.; Brůna, L; Šváb, A.; Buděšínský, Z.

doi:10.1007/bf02872853

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Yeasts of the genus Saccharomyces are particularly rich in sterols (69). Ergosterol has been identified as the major sterol in S. cerevisiae (6,25,76,101), Kluyvero-myces fragilis (234), and C. albicans (43), and can account for over 90% of the total sterol. Strain differences can, however, exist as shown by the major occurrence of ergosta-5,7,22,24(28)-tetraen-3f3-ol in S. cerevisiae N.C.Y.C.…”

Section: Stero +Digtyceridementioning

confidence: 99%

Lipids of yeasts.

Rattray¹,

Schibeci²,

Kidby³

1975

Bacteriological Reviews

191

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Section: Stero +Digtyceridementioning

confidence: 99%

Lipids of yeasts.

Rattray¹,

Schibeci²,

Kidby³

1975

Bacteriological Reviews

191

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“…Resistance may well be anticipated with enhanced Various investigators have offered proof that supports all of these potentials. Capek et al (1974) proved that the advancement of inactivating resistance (induced by an adaptation mechanism) in a C. albicans strain was accompanied by a reduction in cell ergosterol content. This reduction in ergosterol content was caused by suppression of synthesis rather than enzymatic degradation of preformed ergosterol.…”

Section: Mechanism Of Resistance Of Allylaminesmentioning

confidence: 98%

Antifungal chemicals promising function in disease prevention, method of action and mechanism

Dominguez,

Luque-Vilca,

Mallma

et al. 2023

Braz. J. Biol.

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The increasing use of antimicrobial drugs has been linked to the rise of drug-resistant fungus in recent years. Antimicrobial resistance is being studied from a variety of perspectives due to the important clinical implication of resistance. The processes underlying this resistance, enhanced methods for identifying resistance when it emerges, alternate treatment options for infections caused by resistant organisms, and so on are reviewed, along with strategies to prevent and regulate the formation and spread of resistance. This overview will focus on the action mechanism of antifungals and the resistance mechanisms against them. The link between antibacterial and antifungal resistance is also briefly discussed. Based on their mechanism action, antifungals are divided into three distinct categories: azoles, which target the ergosterol synthesis; 5-fluorocytosine, which targets macromolecular synthesis and polyenes, which interact physiochemically with fungal membrane sterols. Antifungal resistance can arise through a wide variety of ways. Overexpression of the target of the antifungal drug, changes to the drug target, changes to sterol biosynthesis, decreased intercellular concentration of the target enzyme, and other processes. A correlation exists between the mechanisms of resistance to antibacterial and antifungals, despite the fact that the comparison between the two is inevitably constrained by various parameters mentioned in the review. Drug extrusion via membrane pumps has been thoroughly documented in both prokaryotic and eukaryotic cells, and development of new antifungal compounds and strategies has also been well characterized.

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