Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae)

Kuete, Victor; Metuno, Robert; Ngameni, Bathélémy; Tsafack, A; Ngandeu, François; Fotso, Ghislain Wabo; Bezabih, Merhatibeb; Etoa, François–Xavier; Ngadjui, Bonaventure T.; Abegaz, Berhanu; Beng, Véronique Penlap

doi:10.1016/j.jep.2007.04.010

Cited by 66 publications

(45 citation statements)

References 15 publications

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“…A serial 2-fold micro-broth dilution method [9] was performed to determine the MICs of plant extract. The crude plant extract was dissolved in dimethylsulfoxide (DMSO) as a stock solution having a concentration of 100 mg/ml.…”

Section: Determination Of the Mic Values Of Plant Extractsmentioning

confidence: 99%

Antioxidant and Antimicrobial Properties of Cistus Ladanifer

Köse¹,

Tekin²,

Bayraktar³

et al. 2017

International Journal of Secondary Metabolite

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Different parts of Cistus species are traditionally used in folk medicine as a remedy for several microbial disorders and infections. At the beginning of the study, crude extract of the Cistus leaves was obtained to determine its antioxidant and antimicrobial activities. Then volatile compounds were extracted using hydrodistillation and hexane. The Cistus oil was obtained by hydrodistillation of fresh material, using leaves in an altered Clevengertype device. Aqueous extract of Cistus leaves was neutralized to precipitate gums. The yield of gum was determined as 1%. Resinoid was obtained after ethanol extraction of gum. Antibacterial activities of extract were determined using disc diffusion and micro-dilution assays against gram-positive and gram-negative bacteria. The extract of Cistus leaves tested and exhibited antibacterial activities by inhibiting one or more microorganisms. The tested plant extract was more active against gram-positive bacteria compared with gram-negative bacteria. Total phenol content of the extract was determined with Folin-ciocalteu method. Total phenolic content of Cistus extract was 520 ± 15 mg Gallic Acid Equivalent (GAE)/ g extract. The water soluble (ACW) and lipid soluble (ACL) antioxidant capacities of the extract were also determined. ACW and ACL antioxidant capacities of Cistus extract were found as 650±80 μg Ascorbic acid/ mg extract and 540 ±30 μg Trolox Equivalent/ mg extract, respectively. In this study, there is a clear relationship between the total antioxidant and phenol content analysis results and antibacterial activities. Hereby, bioactive natural compounds present in Cistus species can be used as natural raw material in some related industrial applications.

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Section: Determination Of the Mic Values Of Plant Extractsmentioning

confidence: 99%

Antioxidant and Antimicrobial Properties of Cistus Ladanifer

Köse¹,

Tekin²,

Bayraktar³

et al. 2017

International Journal of Secondary Metabolite

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show abstract

“…Bark ( (Ruppelt et al, 1991;Adjanohoun et al, 1996;Ngadjui et al, 1998;Dimo et al, 2001), spice Leaves, roots Roots (13.28) Antimicrobial; psoralen; 2-sitosterol glucoside analgesic (Ngadjui et al, 1998;Kuete et al, 2007a) Mimosaceae Tetrapleura tetraptera (Schum. and Thonn) Taub.…”

Section: Whole Plantmentioning

confidence: 99%

“…Antimicrobial: psoralen, bergapten(Lombaert et al, 2001;Kuete et al, 2007a) ApocynaceaePicralima nitida Stapf Th. and H. Dur.…”

unclassified

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

Kuete

Krusche

Youns

et al. 2011

Journal of Ethnopharmacology

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166

106

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“…3) Coumarin has been found to exhibit a wide range of bioactivities, such as hemoprevention against pathogens, 4) herbivores, 5) and abiotic stresses, 6) suggesting that physiological roles of coumarins for plants for the adaption to environmental stresses. Some coumarin derivatives are also known to act beneficially on human health due to their therapeutic effects such as inhibitory activities against various tumor cells, 7,8) mycobacteria, 9) antioxidant, 10,11) antihyperglycemic, 12) antifungal, 13) and antiasthmatic 14) which have been extensively studied in the medical and pharmaceutical fields for the treatment of diseases of human.…”

mentioning

confidence: 99%

Antinociceptive Profiles and Mechanisms of Orally Administered Coumarin in Mice

Park

Sim

Kang

et al. 2013

Biological & Pharmaceutical Bulletin

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In the present study, the antinociceptive profiles of coumarin were examined in ICR mice. Coumarin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of coumarin maintained at least for 60 min. But, the cumulative response time of nociceptive behaviors induced by a subcutaneous (s.c.) formalin injection, intrathecal (i.t.) substance P (0.7 µg) or glutamate (20 µg) injection was not affected by coumarin. 1) Coumarins form a large group of plant polyphenols. Thus far about 1500 coumarin derivatives have been isolated from plants.2) They occur ubiquitously in the plant kingdom, and coumarin derivatives show a chemotaxonomical tendency to accumulate in large amounts in Rutaceae and Apiaceae. 3) Coumarin has been found to exhibit a wide range of bioactivities, such as hemoprevention against pathogens, 4) herbivores, 5) and abiotic stresses, 6) suggesting that physiological roles of coumarins for plants for the adaption to environmental stresses. Some coumarin derivatives are also known to act beneficially on human health due to their therapeutic effects such as inhibitory activities against various tumor cells, 7,8) mycobacteria, 9) antioxidant, 10,11) antihyperglycemic, 12) antifungal, 13) and antiasthmatic 14) which have been extensively studied in the medical and pharmaceutical fields for the treatment of diseases of human.Previous studies have demonstrated that some coumarins exert an antinociceptive action.15,16) However, exact antinociceptive profiles and mechanism of coumarin have not been well characterized. Thus, we, in the current study, tried to characterize antinociceptive profiles and mechanisms of coumarin in several pain models. Experimental Animals Male iCR mice (MJ Co., Seoul, Korea) weighing 20-25 g were used for all the experiments. Animals were housed 5 per cage in a room maintained at 22± 0.5°C with an alternating 12 h light-dark cycle. Food and water were available ad libitum. The animals were allowed to adapt to the laboratory for at least 2 h before testing and were only used once. experiments were performed during the light phase of the cycle (10:00-17:00). MATeRiALS And MeTHOdSDrug Administration Oral administration was performed with gage in a volume of 500 µL/25 g body weight. intraperitoneal (i.p.) injection was conducted to unanesthesized mice with volume of 250 µL. The intracerebroventricular (i.c.v.) administration followed the method described by Haley.17) The intrathecal (i.t.) administration was performed following the method of Hylden and Wilcox 18,19) using a 30-gauge needle connected to a 25 µL Hamilton syringe with polyethylene tubing. The i.c.v. and i.t. injection volumes were 5 µL and the injection sites were verified by injecting a similar volume of 1% methylene blue solution and determining the distribution of the injected dye in the ventricular space or in the spinal cord. The dye injected i.c.v. was found to be distributed through the v...

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Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae)

Cited by 66 publications

References 15 publications

Antioxidant and Antimicrobial Properties of Cistus Ladanifer

Antioxidant and Antimicrobial Properties of Cistus Ladanifer

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

Antinociceptive Profiles and Mechanisms of Orally Administered Coumarin in Mice

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