Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues

Zhou, Jiangfei; Liu, Yongqing; Shen, Tengfei; Chen, Liangliang; Zhang, Cong; Cai, Kairui; Liao, Chengshui; Wang, Chen

doi:10.1016/j.micpath.2019.103712

Cited by 20 publications

(15 citation statements)

References 44 publications

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“…In recent years, our group has performed research on the structural modification and antimicrobial activity of PMAPs. According to the structure and mechanism of PMAPs, many scholars have designed multiple novel modified peptides with increased stability and antimicrobial activity (43)(44)(45)(46)(47)(48)(49)(50). This review mainly summarizes the research progress on the structural characteristics and biological activities of PMAPs in recent years.…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

“…Compared to that of PMAP-36, the antibacterial activities of PMAP-36PW and PMAP-36PK against Gram-positive bacteria and Gram-negative bacteria are also significantly increased, especially against Listeria monocytogenes, with increases in antibacterial activity of 4-to 8fold. In addition, in murine animal model experiments of acute infection with Salmonella choleraesuis and L. monocytogenes, the modified peptide shows therapeutic efficacy comparable to that of the ceftiofur sodium antibiotic (45). Myristic acid has been used to modify the N-terminus of PMAP-36PW to improve hydrophobicity, resulting in a novel modified peptide, Myr-36PW.…”

Section: Antibacterial Activity Of Pmap-36mentioning

confidence: 99%

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Porcine Myeloid Antimicrobial Peptides: A Review of the Activity and Latest Advances

et al. 2021

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Traditional antibiotics have made great contributions to human health and animal husbandry since the discovery of penicillin in 1928, but bacterial resistance and drug residues are growing threats to global public health due to the long-term uncontrolled application of antibiotics. There is a critical need to develop new antimicrobial drugs to replace antibiotics. Antimicrobial peptides (AMPs) are distributed in all kingdoms of life, presenting activity against pathogens as well as anticancer, anti-inflammatory, and immunomodulatory activities; consequently, they have prospects as new potential alternatives to antibiotics. Porcine myeloid antimicrobial peptides (PMAPs), the porcine cathelicidin family of AMPs, have been reported in the literature in recent years. PMAPs have become an important research topic due to their strong antibacterial activity. This review focuses on the universal trends in the biochemical parameters, structural characteristics and biological activities of PMAPs.

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Section: Antimicrobial Peptidesmentioning

confidence: 99%

Section: Antibacterial Activity Of Pmap-36mentioning

confidence: 99%

Porcine Myeloid Antimicrobial Peptides: A Review of the Activity and Latest Advances

et al. 2021

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“…Novel, informed drug-design approaches to identify AMP is aided by the vast sequence space available ( 78 , 283 ). Other approaches have taken known host defence peptides and attempted to optimise them using a variety of approaches ( 281 , 284 – 286 ).…”

Section: Future Directions For Antifungal Peptide Design and Developmmentioning

confidence: 99%

Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response

Mercer

O’Neil

2020

Front. Immunol.

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The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial effects on fungi, we will also discuss compounds with direct antifungal activity, including monoclonal antibodies (mAb), as well as immunomodulatory molecules that can enhance the immune response to fungal infection, including immunomodulatory AMP, vaccines, checkpoint inhibitors, interferon and colony stimulating factors as well as immune cell therapies. The focus of this manuscript will be a non-exhaustive review of antifungal compounds in preclinical and clinical development that are based on the principles of immunology and the authors acknowledge the incredible amount of in vitro and in vivo work that has been conducted to develop such therapeutic candidates.

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“…Antimicrobial peptides (AP) have become attractive potential alternative therapeutic compounds. 8 AP have a wide range of activities, and a broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. 9 , 10 AP kill or suppress benign and pathogenic organisms, thereby disrupting the homeostasis between a healthy microbiota and immune system.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Luminescent CdSe Quantum Dot-Functionalized Antimicrobial Peptides Nanoparticles on Antibacterial Activity and Molecular Mechanism

Song

Xin

et al. 2021

IJN

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Background With the development of bacterial resistance, the range of effective antibiotics is increasingly becoming more limited. The effective use of nanoscale antimicrobial peptides (AP) in therapeutic and diagnostic methods is a strategy for new antibiotics. Methods Combining both AP and cadmium selenide (CdSe) into a composite material may result in a reagent with novel properties, such as enhanced antibacterial activity, fluorescence and favorable stability in aqueous solution. Results AP-loaded CdSe NPs (AP-CdSe NPs) showed strong antibacterial activity against multidrug-resistant (MDR) Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) in vitro and in vivo. Colony-forming unit (CFU) and minimum inhibitory concentration (MIC) assays showed that AP-CdSe NPs have highly effective antibacterial activity. The quantitative analysis of apoptosis by flow cytometry analysis further confirmed that MDR E. coli and S. aureus treated with AP-CdSe NPs had death rates of 98.76% and 99.13%, respectively. Also, AP-CdSe NPs was found to inhibit bacterial activity in an in vivo bacteremia model in mice infected with S. aureus . In addition, the antibacterial mechanism of AP-CdSe NPs was determined by RNA sequencing analysis. Gene ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis revealed the molecular mechanism of the antibacterial effect of AP-CdSe NPs. Importantly, histopathology analysis, and hematological toxicity analysis indicated that AP-CdSe NPs had few side effects. Conclusion These results demonstrate that AP loaded on CdSe NPs had a higher water solubility, bioavailability and antibacterial effect compared with raw AP. This study reports findings that are helpful for the design and development of antibacterial treatment strategies based on AP.

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Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues

Cited by 20 publications

References 44 publications

Porcine Myeloid Antimicrobial Peptides: A Review of the Activity and Latest Advances

Porcine Myeloid Antimicrobial Peptides: A Review of the Activity and Latest Advances

Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response

The Effects of Luminescent CdSe Quantum Dot-Functionalized Antimicrobial Peptides Nanoparticles on Antibacterial Activity and Molecular Mechanism

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