Antimicrobial activity of tannin components from Vaccinium vitis-idaea L.

Ho, Kuen‐Yao; Tsai, Chi‐Cheng; Huang, Jiun-Chi; Chen, C P; Lin, Ta‐Chen; Lin, Chun‐Ching

doi:10.1211/0022357011775389

Cited by 104 publications

(38 citation statements)

References 25 publications

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“…The synergistic activity observed might have been due to the presence of secondary metabolites present in the extracts and oil, such as tannins and flavonoids, which are synthesized by plants in response to microbial infection (Dixon et al, 1983;Ho et al, 2001), where they are capable of disrupting the cell wall or plasma membrane facilitating drug uptake (Figueredo et al, 2013;Matias et al, 2010a;Tsuchiya et al, 1996).…”

Section: Metabolitesmentioning

confidence: 99%

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Figueredo¹,

Lucena²,

Tintino³

et al. 2013

Pharmaceutical Biology

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Context: The combination of antibiotics with natural products has demonstrated promising synergistic effects in several therapeutic studies. Objective: The aim of this study was to determine the effect of a combination of an ethanol extract of Myracrodruon urundeuva Fr. All. (Anacardiaceae) (aroeira plant) and its essential oil with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli from clinical isolates. Materials and methods: After identification of the chemical components by GC-MS, the antibacterial activity of the natural products and antibiotics was assessed by determining the minimal inhibitory concentration (MIC) using the microdilution method and concentrations ranging 8-512 mg/mL and 0.0012-2.5 mg/mL, respectively. Assays were performed to test for a possible synergistic action between the plant products and the antimicrobials, using the extract and the oil at a sub-inhibitory concentration (128 mg/mL) and antibiotic at concentrations varying between 8 and 512 mg/mL. Results: The GC-MS analysis identified the main compound as d-carene (80.41%). The MIC of the natural products was 41024 mg/mL, except against S. aureus ATCC25923. Only the combinations of the natural products with gentamicin, amikacin and clindamycin were effective against S. aureus 358, enhancing the antibiotic activity by reducing the MIC. Conclusions: The extract from aroeira showed a higher antibacterial activity and the oil was more effective in potentiating the activity of conventional antibiotics.

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Section: Metabolitesmentioning

confidence: 99%

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Figueredo¹,

Lucena²,

Tintino³

et al. 2013

Pharmaceutical Biology

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“…pode ser devida à presença de compostos como flavonoides, terpenos ou taninos reconhecidos com atividade para uma ampla variedade de microrganismos (Ho et al, 2001;Rajan et al, 2011).…”

Section: Resultsunclassified

Atividade antimicrobiana dos extratos metanólicos da raiz, caule e folhas de Croton pulegioides Baill. (Zabelê)

Arrais

Lyra

et al. 2014

Rev. bras. plantas med.

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RESUMO: O uso popular de plantas medicinais continua sendo de grande interesse para a população, principalmente em países em desenvolvimento, nos quais o acesso à medicina alopática ainda é muito restrito. Assim, além de sua importância na medicina tradicional, o conhecimento das plantas pode fornecer para a indústria farmacêutica, direta ou indiretamente, princípios ativos de interesse terapêutico. No presente trabalho foi avaliada a atividade antimicrobiana dos extratos metanólicos secos de Croton pulegioides Baill. obtidos a partir da raiz, do caule e das folhas nas concentrações de 25, 50 e 100mg/mL utilizando o método de difusão em Agar (técnica de poços) frente a cinco cepas Gram-positivas, três cepas de fungos e três cepas de bactérias Gram-negativas. Na execução do estudo foi utilizado o antibiótico Gentamicina (100µg/mL) no teste com bactérias, e Cetoconazol (300µg/mL) para as Candidas verificando-se, ao mesmo tempo, a ausência de atividade para o diluente DMSO 20% em água. Na observação dos resultados evidenciaram-se halos de inibição indicando atividade dos extratos metanólicos da raiz, caule e folhas, nas concentrações de 50 e 100mg/ml, frente Bacillus subtilis AM 04; dos extratos metanólicos da raiz e do caule, nas concentrações de 50 e 100mg/ml, frente Staphylococcus aureus AM 103 (ATCC 6538); e do extrato metanólico do caule, nas concentrações de 50 e 100mg/ml, frente S. epidermidis AM 235. Por outro lado, todos os extratos foram inativos nas concentrações avaliadas frente às bactérias Gram-negativas utilizadas no estudo (Pseudomonas aeruginosa AM 206, Escherichia coli AM 1050 e Klebsiella pneumoniae AM 410). Referente à atividade sobre fungos, os extratos metanólicos da raiz e do caule inibiram, nas três concentrações avaliadas, o crescimento de Candida tropicalis AM 1181 e C. albicans AM 1140, enquanto o extrato das folhas, inibiu o crescimento de C. tropicalis AM 1181 nas concentrações de 50 e 100mg/ml e de C. albicans AM 1140 apenas na concentração de 100mg/mL. Finalmente o extrato metanólico das folhas, na concentração de 100mg/mL, foi o único a inibir o crescimento de Candida krusei. Os resultados preliminares apresentados pelo presente trabalho sugeriram que a espécie Croton pulegioides Baill. apresentou resultados promissores quanto ao potencial antimicrobiano. Palavras-chave:Plantas medicinais, Croton pulegioides Baill., Atividade antimicrobiana.ABSTRACT: Antimicrobial activity of methanol extracts of root, stem and leaves of Croton pulegioides Baill. The employment of medicinal plants as a folk custom remains important to the present time, mainly in developing countries, where access to allopathic medicine is restricted. Besides their importance in traditional medicine, the knowledge on these plants can, directly or indirectly, provide information about the active ingredients involved, which may be of interest to the pharmaceutical industry. The present study evaluated the antimicrobial activity of dried methanolic extracts of Croton pulegioides Baill, extracted from its roots, stalk, an...

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“…Three possible mechanisms or their combinations are considered: (1) direct inhibition of microbial activity through toxic effects or inactivation of extracellular enzymes (Ani et al 2006, Scalbert et al 1991, Ho et al 2001) in denitrification, (2) decline in N substrates for denitrification by suppressing N mineralization and nitrification, (3) promotion of N 2 O reduction to N 2 gas through development of the anaerobic environment in the soil. It is well known that tannins can decrease N mineralization by binding proteins in proteintannin complexes (Fierer et al 2001, Kraus et al 2004.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is possible that the application of tannins reduced N 2 O emissions directly by suppressing the denitrification process, through antimicrobial activities towards extracellular enzymes or by direct toxicity to the microbes. Antimicrobial activity is one of the typical characteristics of polyphenolic compounds (Ani et al 2006, Salbert et al 1991, Ho et al 2001. Low-and high-TROPICS Vol.…”

Section: Discussionmentioning

confidence: 99%

The effects of tannins derived from Acacia mangium bark on N2O emissions from water saturated acacia plantation soil

Matsubara

Ohta

2015

Tropics

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To evaluate the potential of tannins derived from Acacia mangium bark to mitigate soil N 2 O emissions, a laboratory incubation study was conducted. We prepared a crude tannin extract by water extraction from A. mangium bark, and fractionated the crude extract into high-and low-molecular-weight tannins (HMTs and LMTs, respectively). Soils were incubated with and without the addition of A. mangium bark tannins and commercial tannic acid after KNO 3 was added and the water-filled pore space was adjusted to 100 %. Acacia mangium bark tannins significantly decreased N 2 O emissions compared with the control. However, they did not significantly affect CO 2 emissions or inorganic N concentrations except for soils with LMTs, where cumulative CO 2 emissions were significantly decreased, and for the fact that NH 4 + contents in tannin-treated soils were significantly lower than in the control soil at 7 days. These results suggest that the antimicrobial activities of purified tannins of A. mangium bark reduced N 2 O emissions by inhibiting denitrification regardless of the degree of polymerization. The crude tannin extract, which probably contained other non-tannic C sources, also reduced N 2 O emissions, suggesting that the toxic effects of HMT and LMT in it would overcome the effects of other C compounds on soil N 2 O emissions. Tannic acid, which is different in structure from condensed tannins, suppressed the N 2 O emission but it was not significant and less effective than HMT and LMT. Our results suggest that the application of A. mangium bark tannins has the potential to mitigate N 2 O emissions from A. mangium plantation soils.

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Antimicrobial activity of tannin components from Vaccinium vitis-idaea L.

Cited by 104 publications

References 25 publications

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Atividade antimicrobiana dos extratos metanólicos da raiz, caule e folhas de Croton pulegioides Baill. (Zabelê)

The effects of tannins derived from <i>Acacia mangium</i> bark on N<sub>2</sub>O emissions from water saturated acacia plantation soil

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