Antimicrobial activity of some species of the family Combretaceae

Elegami, Awatif A.; Elnima, Elamin Ibrahim; Tohami, M. S. El; Muddathir, Abdel Khalig

doi:10.1002/ptr.995

Cited by 39 publications

(41 citation statements)

References 5 publications

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“…La richesse de l'extrait aqueux en ces composés chimiques actifs pourrait expliquer l'utilisation de Bridelia ferruginea en Médecine traditionnelle africaine pour soigner de nombreuses maladies. En effet, plusieurs auteurs ont montré que les types de composés chimiques mis en évidence dans les extraits de cette plante ont des effets thérapeutiques [22][23][24][25][26][27][28][29][30].…”

Section: Discussionunclassified

Etudes phytochimique et pharmacologique de Bridelia ferruginea benth (euphorbiaceae) sur la motricite du Taenia coli de cobaye

Bi¹,

Traoré²,

Soro³

et al. 2010

Afrique Science: Revue Internationale Des Sciences Et Technologie

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RésuméL'étude phytochimique des extraits de Bridelia ferruginea a montré que cette plante contient des quinones, des tanins catéchiques et galliques, des alcaloïdes, des stérols, des polyterpènes, des polyphénols, des composés réducteurs, des flavonoïdes et des saponosides.L'extrait aqueux de Bridelia ferruginea provoque entre 10 -5 mg/mL et 10 -1 mg/mL une augmentation des contractions rythmiques de muscle lisse Taenia coli de cobaye. Ces effets inotropes positifs antagonisés par l'Atropine (10 -6 mg/mL) sont totalement abolis en milieu pauvre (0Ca 2+ ) et dépourvus de calcium (0Ca 2+ + EDTA 10 -5 M).Ces résultats suggèrent la présence de substances cholinomimétiques dans l'extrait brut. Ces substances favoriseraient l'entrée de calcium dans la cellule musculaire lisse par stimulation des récepteurs muscariniques. Ces substances cholinomimétiques justifieraient l'usage traditionnel de cette plante comme laxatif ou purgatif. Mots-clés :Bridelia ferruginea, Taenia coli, récepteur muscarinique. AbstractPhytochemical and pharmacological studies of bridelia ferruginea benth (euphorbiaceae) on guinea pig taenia coli motility.The phytochemical study of Bridelia ferruginea extracts revealed that the plant contained quinones, catechic and gallic tannins, alkaloids, sterols, polyterpenes, polyphenols, reducing compounds, flavonoids and saponins. The aqueous extract of Bridelia Afrique SCIENCE 05 (2) (2009) 305 -320 Semi Anthelme NENE BI et al. 306ferruginea, for concentrations ranging from 10 -5 mg/mL to 10 -1 mg/mL, caused an increase of the rhythmical contraction of guinea pig Taenia coli smooth muscle. These positive inotropic effects inhibited by Atropine (10 -6 mg/mL) were completely abolished in poor calcium mediums (0Ca 2+ ; 0Ca 2+ + EDTA 10 -5 M). The results suggested the presence of cholinomimetic substances in the crude extract of Bridelia ferruginea. Therefore, the inward calcium flow into the smooth muscle cell would be due to the stimulation of muscarinic cholinoceptors induced by these substances. In conclusion, the traditional use of this plant as a laxative is justified by the presence of these cholinomimetic substances.

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Section: Discussionunclassified

Etudes phytochimique et pharmacologique de Bridelia ferruginea benth (euphorbiaceae) sur la motricite du Taenia coli de cobaye

Bi¹,

Traoré²,

Soro³

et al. 2010

Afrique Science: Revue Internationale Des Sciences Et Technologie

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“…In Africa, where access to modern medical facilities is limited (Elegami et al . ), the use of pharmaceutical drugs is an exception to the general trend (Koduru et al . ) as up to 90% of the African population depends directly on traditional medicine for treating illnesses (Staden ; Hostettmann et al .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, 25% of modern drugs are derived from plants traditionally used as medicine (Sahoo et al 2010). In Africa, where access to modern medical facilities is limited (Elegami et al 2002), the use of pharmaceutical drugs is an exception to the general trend (Koduru et al 2007) as up to 90% of the African population depends directly on traditional medicine for treating illnesses (Staden 1999;Hostettmann et al 2000;Fyhrquist 2007;WHO 2009). In South Africa, for example,~80% of the population depend on traditional herbal medicine for their primary health care, with more than 25 000 practicing traditional healers (http://www.tac.org.…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic exploration of commonly used medicinal plants in South Africa

Yessoufou

Daru

Muasya

2014

Molecular Ecology Resources

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The rapid growth rate of human population, along with the public health crisis encountered in many regions, particularly in developing world, creates an urgent need for the discovery of alternative drugs. Because medicinal plants are not distributed randomly across lineages, it has been suggested that phylogeny along with traditional knowledge of plant uses can guide the identification of new medicinally useful plants. In this study, we combined different statistical approaches to test for phylogenetic signal in 33 categories of plant uses in South Africa. Depending on the null models considered, we found evidence for signal in up to 45% of plant use categories, indicating the need for multiple tests combination to maximize the chance of discovering new medicinal plants when applying a phylogenetic comparative approach. Furthermore, although there was no signal in the diversity of medicinal uses-that is, total number of medicinal uses recorded for each plant-our results indicate that taxa that are evolutionarily closely related have significantly more uses than those that are evolutionarily isolated. Our study therefore provides additional support to the body of the literature that advocates for the inclusion of phylogeny in bioscreening medicinal flora for the discovery of alternative medicines.

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“…The plant is widespread throughout the Sahel belt from Senegal to Cameroon, and eastwards to the Sudan [12]. Leaves, fruits and stem bark extracts of C. hartmannianum showed activity against Gram-positive bacteria, E. coli (Gram-negative); and have also been reported to exhibit anti-inflammatory activity [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

Inhibitory activities of selected Sudanese medicinal plants on Porphyromonas gingivalis and matrix metalloproteinase-9 and isolation of bioactive compounds from Combretum hartmannianum (Schweinf) bark

Mohieldin

Muddathir

Mitsunaga

2017

BMC Complement Altern Med

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BackgroundPeriodontal diseases are one of the major health problems and among the most important preventable global infectious diseases. Porphyromonas gingivalis is an anaerobic Gram-negative bacterium which has been strongly implicated in the etiology of periodontitis. Additionally, matrix metalloproteinases-9 (MMP-9) is an important factor contributing to periodontal tissue destruction by a variety of mechanisms. The purpose of this study was to evaluate the selected Sudanese medicinal plants against P. gingivalis bacteria and their inhibitory activities on MMP-9.MethodsSixty two methanolic and 50% ethanolic extracts from 24 plants species were tested for antibacterial activity against P. gingivalis using microplate dilution assay method to determine the minimum inhibitory concentration (MIC). The inhibitory activity of seven methanol extracts selected from the 62 extracts against MMP-9 was determined by Colorimetric Drug Discovery Kit. In search of bioactive lead compounds, Combretum hartmannianum bark which was found to be within the most active plant extracts was subjected to various chromatographic (medium pressure liquid chromatography, column chromatography on a Sephadex LH-20, preparative high performance liquid chromatography) and spectroscopic methods (liquid chromatography-mass spectrometry, Nuclear Magnetic Resonance (NMR)) to isolate and characterize flavogalonic acid dilactone and terchebulin as bioactive compounds.ResultsAbout 80% of the crude extracts provided a MIC value ≤4 mg/ml against bacteria. The extracts which revealed the highest potency were: methanolic extracts of Terminalia laxiflora (wood; MIC = 0.25 mg/ml) followed by Acacia totrtilis (bark), Ambrosia maritima (aerial part), Argemone mexicana (seed), C. hartmannianum (bark), Terminalia brownii (wood) and 50% ethanolic extract of T. brownii (bark) with MIC values of 0.5 mg/ml. T. laxiflora (wood) and C. hartmannianum (bark) which belong to combretaceae family showed an inhibitory activity over 50% at the concentration of 10 μg/ml against MMP-9. Additionally, MMP-9 was significantly inhibited by terchebulin with IC50 value of 6.7 μM.ConclusionsTo the best of our knowledge, flavogalonic acid dilactone and terchebulin were isolated from C. hartmannianium bark for the first time in this study. Because of terchebulin and some crude extracts acting on P. gingivalis bacteria and MMP-9 enzyme that would make them promising natural preference for preventing and treating periodontal diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1735-y) contains supplementary material, which is available to authorized users.

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Antimicrobial activity of some species of the family Combretaceae

Cited by 39 publications

References 5 publications

Etudes phytochimique et pharmacologique de <i>Bridelia ferruginea</i> benth (euphorbiaceae) sur la motricite du <i>Taenia coli</i> de cobaye

Etudes phytochimique et pharmacologique de <i>Bridelia ferruginea</i> benth (euphorbiaceae) sur la motricite du <i>Taenia coli</i> de cobaye

Phylogenetic exploration of commonly used medicinal plants in South Africa

Inhibitory activities of selected Sudanese medicinal plants on Porphyromonas gingivalis and matrix metalloproteinase-9 and isolation of bioactive compounds from Combretum hartmannianum (Schweinf) bark

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