Antimicrobial activity of some 2- and 3-pyridinyl-1H-benzimidazoles and their FeIII, CuII, ZnII, and AgI complexes

Abstract

2-(2-Pyridinyl)- (LI), 2-(6-methyl-2-pyridinyl)- (LII), 2-(6-methyl-2-pyridinyl)-5-methyl-(LIII), 2-(3-pyridinyl)- (LIV), 2-(3-pyridinyl)-5-methyl-1H-benzimidazoles (LV) and their complexes with Fe(NO3)3, Cu(NO3)2, Zn(NO3)2, and AgNO3 were synthesized and antibacterial activity of the compounds was tested toward Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity against Candida albicans. The methyl groups of LIII increase the antimicrobial activity. The AgI complexes have considerable activity toward the microorganisms. Some ZnII complexes show an antimicrobial effect against S. aureus and S. flexneri, although the ligands themselves have no effect. CuII complexes have a considerable antibacterial effect to S. aureus and S. epidermidis.

Spectral characterization and antimicrobial activity of 2-(5-chloro/nitro-1H-benzimidazol-2-yl)-4-bromo/nitro-phenols and their zinc(II) complexes

“…For example, Zn(II) complexes of 1,2-bis-[(5-Cl/NO 2 )-2-1H-benzimidazolyl]-1,2-ethanediols were effective on Staphylococcus aureus and Staphylococcus epidermidis [17]. Zn(II) complexes of some 2-pyridinyl-1H-benzimidazoles showed selective antimicrobial effect against S. aureus and S. flexneri although the ligands themselves had no effect [18]. Antibacterial activity of 1-benzylbenzimidazole derivatives and their Zn(II) complexes was evaluated.…”

Synthesis, structure and biological activities of cobalt(II) and zinc(II) coordination compounds with 2-benzimidazole derivatives

“…Coordination compounds of benzimidazole derivatives with transition metal ions have been used to prepare structural and spectroscopic models of the active sites of some metalloenzymes [18], but the investigation concerned with their biological activity has been limited to thiabendazole coordination compounds with Co(II), Cu(II), Ni(II) and Zn(II) [6,19] and 2-substituted pyridinyl derivatives of Fe(III), Co(II), Zn(II), Ag(I) and Hg(II) [20][21][22].…”

Synthesis, a case of isostructural packing, and antimicrobial activity of silver(i)quinoxaline nitrate, silver(i)(2,5-dimethylpyrazine) nitrate and two related silver aminopyridine compounds

“…2,9, 10 Nevertheless, there is some current interest in investigating and applying new and more sophisticated Ag(I) compounds for their a antimicrobial activity. 3,[11][12][13][14][15][16][17][18][19][20][21][22][23] The exact mode of action of these compounds is unknown on a molecular level, but interference with electron transport, binding to DNA, and interactions with cell membranes have each been proposed. 24 Furthermore, there seem to be very few clear correlations between the chemical properties, structure and connectivity of the tested compounds and their antimicrobial activity (which may vary widely).…”