Antimicrobial activity of Saponins rich fraction of Cassia auriculata Linn against various microbial strains

Abstract

In the present investigation, the saponins rich fraction of roots of Cassia auriculata L. was evaluated for antimicrobial activity against P. vesicularis, Streptococcus faecalis, Aeromonas hydrophilia, Salmonella typhae, Staphylococcus cohni, Serratia ficaria and E. coli at concentration of 12.5 mg/ml, 25 mg/ml, 37.5 mg/ml and 50 mg/ml. Antimicrobial activity of Cassia auriculata L. was carried out by well diffusion method. At maximum conc. i.e. 50mg/ml, antimicrobial effect of Saponin rich extract can be arranged in sequence of - P. vesicularis > Serratia ficaria > Streptococcus cohni > Aeromonas hydrophilic> Salmonella typhae > Sterptococcus faecalis > E. coli. The results indicate the saponins rich fraction of roots of Cassia auriculata L. might be exploited as natural drug for the treatment of several infectious diseases caused by these organisms. Cassia auriculata L. was observed to have antibacterial activity and can be used for medicinal purposes.DOI: http://dx.doi.org/10.3329/icpj.v2i4.14056 International Current Pharmaceutical Journal, March 2013, 2(4): 85-87

Saponin: Properties, Methods of Evaluation and Applications

“…They were concluded that L. vannamei immersed in water containing saponin could protect against V. alginolyticus infection [48]. [52]. It has been previously reported that C. albicans, and C. tropicalic were sensitive to the saponins of G. glabra and Q. saponaria [53].…”

Efficacy of Crude Leaf Extracts of Aloe secundiflora on Selected Enteric Bacterial Pathogens and Candida albicans

“…There has been evidence of presence of saponins in traditional medicine preparations where administration is through oral means that is expected to lead to the hydrolysis of glycosides from terpenoids [37]. Studies carried out have shown medicinal plant extracts fractions rich in saponins are effective against microorganisms such as Escherichia coli, Salmonella typhi, Aeromonas hydrophilia and other fungal pathogens such as Candida albicans [38]. Saponins antimicrobial activity is attributed mainly to its capability of lysing microorganism's membranes rather than the surface tension of the extracellular medium [37].…”

Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property

“…The probable mechanism of antimutagenic activity of methanolic extract of Senna auriculata (L.) Roxb. bark, could be due to presence of excellent scavengers of reactive oxygen species (ROS) like singlet oxygen and/or superoxide anion radical whichplay a central role in multistage mutagenesis and carcinogenesis ( EFSA Scientific Committee, 2011 ; Deshpande et al, 2013a ; Deshpande et al, 2013b ).…”

“…The result indicates the saponins rich fraction of roots of Senna auriculata (L.) Roxb. might be exploited as natural drug for the treatment of several infectious diseases caused by these organisms ( Deshpande et al, 2013a ; Deshpande et al, 2013b ).…”

“…did not produce any significant changes in the autonomic or behavioral changes including death during the observation period ( Annie et al, 2005 ). Deshpande et al (2013a) also carried out an acute toxicity study (OECD 423 guideline) at different dose levels of 5, 50, 300, and 2,000 mg/kg of ethyl acetate extract of roots of Senna auriculata (L.) Roxb. The rats did not show any toxic effects as well as any significant variation in their behavior.…”