Antimicrobial Activity of Platelet‐Rich Plasma and Other Plasma Preparations Against Periodontal Pathogens

Yang, Li‐Chiu; Hu, Sung-Yuan; Yan, Min; Yang, Jaw‐Ji; Tsou, Sing-Hua; Lin, Yung‐Ya

doi:10.1902/jop.2014.140373

Cited by 56 publications

(66 citation statements)

References 39 publications

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“…The authors found that all plasma preparations can inhibit bacterial growth, with PRP showing the superior activity. In the current study, the activity of PRP against A. actinomycetemcomitans and P. gingivalis is comparable to that of Yang et al (2015). These results confirm the beneficial role of PRP in the treatment of periodontal disease.…”

Section: Discussionsupporting

confidence: 84%

Antiviral Resistance of Splenocytes in Aged Mice

Zaczyńska

Artym

Kocięba

et al. 2017

Polish Journal of Microbiology

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A b s t r a c tAntimicrobial properties of platelet rich plasma (PRP) against various microorganisms have been recently pointed out. PRP could be an alternative to conventional antibiotics in preventing oral and periodontal infections. We examined whether PRP has in vitro antimicrobial properties against Aggregatibacter actinomycetemcomitans, Prophyromonas gingivalis, Staphylococcus aureus and Candida albicans. PRP and platelet-poor plasma (PPP) were obtained from whole blood of 10 healthy volunteers and 10 periodontitis patients. In vitro laboratory susceptibility was carried out using the modified agar diffusion method by measuring the diameters of inhibition zones on agar plates coated with selected microbial strains. Both calcium chloride (CaCl2) activated and non activated samples were tested. Both activated PRP and PPP, of both patients and controls, effectively inhibited the growth of A. actinomycetemcomitans, P. gingivalis and C. albicans. However, a statistically significant difference in favor of PRP was found indicating more susceptibility to PRP than PPP (p < 0.05). Non activated PRP and PPP exhibited negative zones of inhibition against the studied microorganisms. There was no activity against S. aureus. No statistically significant difference was found between the antimicrobial effects of PRP and/or PPP obtained from patients and controls (p > 0.05). We conclude that PRP is a potentially useful substance against oral and periodontal pathogens. Activated PRP was found to be more active than activated PPP and the activation of coagulation is a fundamental step. Additionally, the antimicrobial activity of PRP and/or PPP seems not to be affected by periodontitis.K e y w o r d s: antimicrobial activity, oral infection, platelet-rich plasma

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Section: Discussionsupporting

confidence: 84%

Antiviral Resistance of Splenocytes in Aged Mice

Zaczyńska

Artym

Kocięba

et al. 2017

Polish Journal of Microbiology

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“…Anitua et al[61] demonstrated that even if an additional dose of leukocytes was present it did not significantly enhance the antimicrobial properties of PRP. Yang et al[108] (2015) in a study evaluated the antimicrobial activity of four plasma preperations: PRP, platelet poor plasma (PPP), platelet depleted plasma (PDP) and PRF. Using haemocytometer, they found leucocytes only in PRP and not in other preparations.…”

Section: Discussionmentioning

confidence: 99%

“…However, one should note that the technique of PRF preparation was not according to the L-PRF protocol given by Choukroun et al[22] in 2000. To make PRF, Yang et al[108] used fraction of PRP and activated it by 23 mmol/L of calcium chloride for 30 min and centrifuged again at 6000 g for 30 min to recover “fibrin-free supernatant” which they labeled as PRF. Hence, although their experiment highlighted the antimicrobial effect of plasma, regardless of platelet and leukocyte concentration, their conclusion of PRF should be read with caution.…”

Section: Discussionmentioning

confidence: 99%

Evolution, current status and advances in application of platelet concentrate in periodontics and implantology

Agrawal¹

2017

WJCC

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Platelet concentrates (PC) [platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)] are frequently used for surgical procedures in medical and dental fields, particularly in oral and maxillofacial surgery, plastic surgery and sports medicine. The objective of all these technologies is to extract all the elements from a blood sample that could be used to improve healing and promote tissue regeneration. Although leukocyte rich and leukocyte poor PRP’s have their own place in literature, the importance of non-platelet components in a platelet concentrate remains a mystery. PC have come a long way since its first appearance in 1954 to the T-PRF, A-PRF and i-PRF introduced recently. These PC find varied applications successfully in periodontics and implant dentistry as well. However, the technique of preparation, standing time, transfer process, temperature of centrifuge, vibration, etc., are the various factors for the mixed results reported in the literature. Until the introduction of a proper classification of terminologies, the PC were known by different names in different countries and by different commercial companies which also created a lot of confusion. This review intends to clarify all these confusion by briefing the exact evolution of PC, their preparation techniques, recent advances and their various clinical and technical aspects and applications.

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“…We read with great interest the article by Yang et al 1 We would like to commend the authors for exploring for the first time the antibacterial aspect of platelet‐rich plasma and other plasma preparations. Our concern was regarding the protocol followed for preparation of plasma‐rich fibrin (PRF), which according to authors was in accordance with a modified method of Kawazoe and Kim 2 .…”

mentioning

confidence: 99%

Letter to the Editor: Re: Antimicrobial Activity of Platelet‐Rich Plasma and Other Plasma Preparations Against Periodontal Pathogens

Gopal

Kumar

2016

Journal of Periodontology

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Antimicrobial Activity of Platelet‐Rich Plasma and Other Plasma Preparations Against Periodontal Pathogens

Abstract: PRP expressed antibacterial properties, which may be attributed to platelets possessing additional antimicrobial molecules. The application of PRP on periodontal surgical sites is advisable because of its regenerative potential and its antibacterial effects.

Cited by 56 publications

References 39 publications

Antiviral Resistance of Splenocytes in Aged Mice

Antiviral Resistance of Splenocytes in Aged Mice

Evolution, current status and advances in application of platelet concentrate in periodontics and implantology

Letter to the Editor: Re: Antimicrobial Activity of Platelet‐Rich Plasma and Other Plasma Preparations Against Periodontal Pathogens

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