Antimicrobial Activity of Plant Secondary Metabolites: A Review

Compean, Kassandra L.; Ynalvez, Ruby A.

doi:10.3923/rjmp.2014.204.213

Cited by 132 publications

(45 citation statements)

References 11 publications

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“…The most important phytochemical constituents responsible for the reduction and capping of silver nanoparticles as revealed by FTIR and phytochemical studies are alkaloids, flavonoids, tannins, terpenes and quinones [64]. Table 3 summarizes the phytochemical constituents of the reviewed plants.…”

Section: Fourier Transforms Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Green synthesis of silver nanoparticles mediated by traditionally used medicinal plants in Sudan

2019

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Sudan has a tremendous wealth flora due to its unique geographical location and diverse climate. Vast records of plants and plants' secondary metabolites are reported to possess redox capacity and can be exploited for the biosynthesis of nanoparticles. Plant-mediated synthesis of silver nanoparticles is preferred due to their availability and their various metabolites. The present review explores the potentiality and diversity of biological activities of silver nanoparticles that originated from the combination of silver and phyto-constituents of mostly traditionally used Sudanese medicinal and aromatic plants. The green synthesis methods of silver nanoparticles mediated by more than 45 traditionally used medicinal plants are critically reviewed. In addition, parameters that affect the synthesis of plant-mediated silver nanoparticles, their characterization techniques and various biological activities are summarized and discussed. Thus, the study of green synthesis of silver nanoparticles and its applications can be extended to involve vast plant diversity of Sudan.

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Section: Fourier Transforms Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Green synthesis of silver nanoparticles mediated by traditionally used medicinal plants in Sudan

2019

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“…According to Mirghani et al (2012) study, high amount of phenol is reported in C. citratus . Previously reported data on phenolic compounds including flavonoids validate that, these compounds contain polar hydroxyl groups which were responsible for antioxidants, free radical scavenger, anti-bacterial and anti-inflammatory actions (Cheel et al, 2005; Compean and Ynalvez, 2014; Pratiwi and Elin, 2016). Researcher additionally believed that inhibitory impact of bioactive component (terpenoids and phenols) is due to the interaction and disruption of enzymes and proteins useful for microbial metabolism (Ashraf et al, 2016).…”

Section: Resultsmentioning

confidence: 82%

Analytical Investigation of Cymbopogon citratus and Exploiting the Potential of Developed Silver Nanoparticle Against the Dominating Species of Pathogenic Bacteria

et al. 2019

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Indian biodiversity is a hub for medicinal plants. Extensive research has been carried out to select plants with numerous properties which can be used for human welfare. Present research is about Cymbopogon citratus , an economically valuable medicinal plant. In this study Cymbopogon citratus was elected as a subject plant over the five selected plants ( Azadirachta indica , Plumeria obtuse , Sapindus mukorossi , Capsicum annuum and Phyllanthus emblica ) on the basis of antibacterial effect against dominating pathogenic species of gram positive ( Bacillus cereus, Bacillus licheniformis ) and gram negative ( Pseudomonas aeruginosa, Escherichia coli ) bacteria. Further, bioactive agents behind antibacterial potential of Cymbopogon citratus was analyzed using analytical method (Phyto-chemical, FTIR, NMR and GC-MS). Due to the broad antimicrobial spectrum, silver nanoparticles have turned into a noteworthy decision for the improvement of new medication. Therefore, this investigation further elaborated in the development of Cymbopogon citratus silver nano-particles (CNPs). Antibacterial potential of CNPs examine in a range of C 25 –C 150 (μg/ml) through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) where, C 25 (μg/ml) concentration of CNPs were recorded as the MIC for all bacterial species and C 25 (μg/ml) and C 50 (μg/ml) noted as the MBC for Pseudomonas aeruginosa, Escherichia coli and Bacillus cereus, Bacillus licheniformis , respectively. In agar disk diffusion assay of CNPs, maximum diameter of zone of inhibition was observed for C 150 (μg/ml) concentration Bacillus cereus (20.12 ± 0.42), Bacillus licheniformis (22.34 ± 0.4), Pseudomonas aeruginosa (35.23 ± 0.46) and Escherichia coli (31.87 ± 0.24). Involvement of bioactive component as a reducing and capping agent can be confirmed through FTIR spectrum of CNPs. Moreover XRD, EDXRF and SEM showed crystalline and cuboidal nature of CNPs with ∼ 35 nm sizes. Prominently, cytotoxic analysis was conducted to understand the toxic effect of CNPs. This research highlights the potential of CNPs due to the bioactive components present in Cymbopogon citratus extract: Polyphenols (phenol; 1584.56 ± 16.32 mg/L, Flavanoids) and mixture of terpenoids (Citral, Myrcene, Farnesol, β-myrcene and β –Pinene)

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“…Some of the extracts had high MIC values (1.25–2.5 mg/mL) that is an indication of lack of activity against tested microorganisms. The secondary metabolites, namely, terpenoids, steroids and flavonoids were detected in the extracts (Table 1) and these compounds are known to have antibacterial activities [48]. Previous studies has reported antibacterial activity of D. cinerea against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans [49].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial activity and in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arn extracts against common diarrhoea-causing waterborne bacteria

Shandukani

Tshidino

Masoko

et al. 2018

BMC Complement Altern Med

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BackgroundBidens pilosa and Dichrostachys cinerea extracts were investigated for the antibacterial properties against waterborne diarrhoeagenic bacteria.MethodsThe plant materials were extracted using the direct and serial exhaustive methods using solvents of varying polarities, namely, hexane, dichloromethane, ethyl acetate, acetone and methanol. Qualitative phytochemical analysis and quantitative determination of total phenolic content of the leaf powders of the two plants were tested. The antioxidant activities of the plants were determined using the 2, 2-diphenyl-1-picrylhydrazyl method. The toxic effect of the extracts on C2C12 muscle cell line were assessed by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide method and the antibacterial activity was determined using the serial microbroth dilution.ResultsMethanol leaf extracts both plants had the highest yield in both direct and serial exhaustive extraction methods. Phytochemical profiling of the extracts displayed the presence of various secondary metabolites. The Benzene: ethanol: ammonia hydroxide solvent system showed a good resolution of chemical compounds in plant extracts from both plants. Most antioxidant compounds observed were developed in chloroform: ethyl acetate: formic acid and ethyl acetate: methanol: water solvent systems. All the bacterial species tested were sensitive to the effect of different extracts of both plant species, with E. coli being less sensitive to the effect of the extracts from D. cinerea. Following the simulated gastric fluid (SGF) treatment, a decrease in the antibacterial potency of the extracts was observed. No extract was toxic to the C2C12 muscle cell line.ConclusionThe presence of the secondary metabolites and nontoxic effect of the two plants tested may affirm the medicinal value of these leaf extracts. Our results suggest that B. pilosa and D. cinerea contain constituents with antioxidant and antimicrobial activities, which could be used in the treatment of diarrhoea in a case where untreated surface water is used.

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Antimicrobial Activity of Plant Secondary Metabolites: A Review

Cited by 132 publications

References 11 publications

Green synthesis of silver nanoparticles mediated by traditionally used medicinal plants in Sudan

Green synthesis of silver nanoparticles mediated by traditionally used medicinal plants in Sudan

Analytical Investigation of Cymbopogon citratus and Exploiting the Potential of Developed Silver Nanoparticle Against the Dominating Species of Pathogenic Bacteria

Antibacterial activity and in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arn extracts against common diarrhoea-causing waterborne bacteria

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