Antimicrobial activity of honey in periodontal disease: a systematic review

Abstract

Background Honey has shown positive antimicrobial and anti-inflammatory actions in several dermatological studies; however, it is unclear if it could be effective in the treatment of periodontal disease. Objectives To answer the question: Does honey have antimicrobial activity against periodontopathogens? Methods Six electronic databases were screened from initiation to 31 January 2019 for randomized clinical trials (RCTs) and controlled in vitro studies exploring the antimicrobial effect of honey against periodontopathogens. Honey’s botanical origin, periopathogens that showed microbial susceptibility to honey, MICs, microbial growth conditions, control product and clinical follow-up were the main investigated outcomes. The risk of bias (RoB) of included RCTs was assessed using the Cochrane Collaboration RoB tool. The RoB of in vitro studies was evaluated based on the Sarkis-Onofre judgement model adapted to the context of honey. Results A total of 1448 publications were found as search results in the screened databases. Sixteen eligible papers were included based on predetermined inclusion criteria. Retained studies included 5 RCTs and 11 in vitro controlled trials. Manuka and multifloral honeys were the most studied varieties. The tested honeys showed a significant antimicrobial action, with different MICs, against eight periopathogens. Four of the five RCTs showed a high RoB, while 4 of the 11 retained in vitro studies showed a medium RoB. Conclusions Honey showed a significant antimicrobial activity against all targeted periopathogens. Additional experiments are required to explore the entire antimicrobial spectrum of honey towards all pathogens involved in periodontal disease.

Oral Mucositis Induced by Chemoradiotherapy in Head and Neck Cancer—A Short Review about the Therapeutic Management and the Benefits of Bee Honey

“…There are many studies in the literature on the usefulness of honey in the prevention and treatment of OM based on the biological properties of this agent. As an anti-inflammatory and antimicrobial agent and immunomodulator, this natural product has a great impact on OM [8][9][10][11]13,51,52]. For example, Pradip Kumar Maiti et al conducted a study on 50 patients diagnosed with head and neck cancer who were radiotreated and divided into two study groups.…”

“…The management of oncological toxicities is a challenge for clinicians today, especially concerning the education of patients in regards to the oral hygiene, diet, and lifestyle changes, as well as the management of pain according to intensity, symptoms, prevention of complications, prophylaxis, or treatment of secondary infections [26]. A crucial aspect is an early diagnosis and appropriate treatment of dental diseases [9,35].…”

“…One of the best known natural agents is honey, which can be defined as a heterogeneous mixture of substances such as proteins, sugars, which come from the nectar of flowers and glandular secretions produced by bees. Honey is an extremely complex product and can be considered both a plant and an animal product [8,9]. Honey contains more than 200 different natural compounds, grouped into macro and micronutrients, depending on the type of bees, natural floral source, environmental factors and processing methods.…”

The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

“…Natural products attract more and more attention in periodontitis treatment due to their therapeutic potential, cost-effectiveness, enough source, and safety. A series of natural products such as honey, propolis, cannabidiol, and green tea show various benefits in periodontitis treatment and prevention including inhibition of periodontal pathogens, anti-inflammation, immunomodulation, and osteogenesis (76)(77)(78)(79)(80)(81)(82)(83)(84)(85). But the low stability, uncertain bioavailability, and limited therapeutic effect of natural products limit their clinical application.…”

Effects of Treatment Combining 9300 nm Carbon Dioxide Lasers and Fluoride on Prevention of Enamel Caries: A Systematic Review and Meta-Analysis

“…Concerning the included in vitro studies, the risk of bias assessment was based on and adapted from the judgement model suggested by previous systematic reviews [34][35][36] for the assessment of risk of bias in in vitro trials. Therefore, the following eight domains were considered: quality check of samples; randomization of samples; sample-size calculation; homogeneity of samples; details of laser parameters used; fluoride application protocol; operator training; and blinding of operator.…”