Antimicrobial Activity of Gentiana lutea L. Extracts

Šavikin, Katarina; Menković, Nebojša; Zdunić, Gordana; Stević, Tatjana; Radanović, Dragoja; Janković, Teodora

doi:10.1515/znc-2009-5-606

Cited by 45 publications

(33 citation statements)

References 4 publications

(5 reference statements)

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“…1), a natural bioactive xanthone C-glycoside originated from Mangifera indica L. (Anacardiaceae) (Aritomi and Kawasaki, 1969), possesses a wide spectrum of pharmacological activities, including antioxidant (Das et al, 2012), antiinflammatory (Das et al, 2012), antidiabetic (Sellamuthu et al, 2009), anticancer (Shoji et al, 2011), antibacterial (Savikin et al, 2009), anti-human immunodeficiency virus , and radioprotective (Jagetia and Baliga, 2005) actions. Owing to its remarkable bioactivities, mangiferin has attracted increasing attention as a potential candidate.…”

Section: Introductionmentioning

confidence: 99%

Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats

Liu

Pan

et al. 2012

Drug Metab Dispos

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ABSTRACT:To clarify the role of the intestinal flora in the absorption and metabolism of mangiferin and to elucidate its metabolic fate and pharmacokinetic profile in diabetic rats, a systematic and comparative investigation of the metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin (STZ)-induced diabetic rats was conducted. Forty-eight metabolites of mangiferin were detected and identified in the urine, plasma, and feces after oral administration (400 mg/kg). Mangiferin underwent extensive metabolism in conventional rats and diabetic rats, but the diabetic rats exhibited a greater number of metabolites compared with that of conventional rats. When the intestinal flora were inhibited, deglycosylation of mangiferin and sequential biotransformations would not occur. Pharmacokinetic studies indicated a 2.79-and 2.35-fold increase in the plasma maximum concentration and the area under the concentration-time curve from 0 to 24 h of mangiferin in diabetic rats compared with those for conventional rats, whereas no significant differences were observed between conventional rats and pseudo-germ-free rats. Further real-time quantitative reverse transcription-polymerase chain reaction results indicated that the multidrug resistance (mdr) 1a level in the ileum increased, whereas its level in the duodenum and the mdr1b mRNA levels in the duodenum, jejunum, and ileum decreased in diabetic rats compared with those in conventional rats. With regard to the pseudo-germ-free rats, up-regulated mdr1a mRNA levels and down-regulated mdr1b mRNA levels in the small intestines were observed. The diabetic status induced increased UDP-glucuronosyltransferase (UGT) 1A3, UGT1A8, UGT2B8, and sulfotransferase (SULT) 1A1 mRNA levels and decreased catechol-Omethyltransferase (COMT), UGT2B6, UGT2B12, and SULT1C1 mRNA levels. These results might partially explain the different pharmacokinetic and metabolic disposition of mangiferin among conventional and model rats.

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Section: Introductionmentioning

confidence: 99%

Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats

Liu

Pan

et al. 2012

Drug Metab Dispos

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“…30 Its Methanol extract of flowers and leaves, as well as separated mangiferin, isogentisin, and gentiopicrin show antimicrobial activity against Gram-positive and -negative bacteria as well as the yeast Candida albicans. 31 In one study, the topical application of Teucrium polium L extract accelerated healing of burn wounds. 32 Inhibition of carrageenan-induced inflammation in an animal study showed the anti-inflammatory effect of this plant.…”

Section: Discussionmentioning

confidence: 99%

An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Hosseinkhani

Falahatzadeh

Raoofi

et al. 2016

J Evid Based Complementary Altern Med

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Research on wound healing agents is a developing area in biomedical sciences. Traditional Persian medicine is one of holistic systems of medicine providing valuable information on natural remedies. To collect the evidences for wound-healing medicaments from traditional Persian medicine sources, 5 main pharmaceutical manuscripts in addition to related contemporary reports from Scopus, PubMed, and ScienceDirect were studied. The underlying mechanisms were also saved and discussed. Totally, 65 herbs used in traditional Persian medicine for their wound healing properties was identified. Related anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities of those remedies were studied. Forty remedies had at least one of those properties and 10 of the filtered plants possessed all effects. The medicinal plants used in wound healing treatment in traditional Persian medicine could be a good topic for further in vivo and clinical research. This might lead to development of effective products for wound treatment.

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“…The study also reported that mangiferin did not affect locomotion or motivation. Savikin and co-workers investigated the antimicrobial activity of mangiferin, isogentisin and gentiopicrin, isolated from methanolic extracts of flowers and leaves of Gentiana lutea L., on various gram-positive and gram-negative bacteria as well as the yeast Candida albicans with MIC values ranging from 0.12-0.31 mg/ml [120]. Yoshikawa and group have evaluated the lipolytic effects exhibited by mangiferin at 100 mg/L (P < 0.01) and concluded that it may be involved in the antiobesity effects of Salacia reticulata in rats by inhibition of fat metabolizing enzymes (pancreatic lipase, lipoprotein lipase and glycerophosphate dehydrogenase) and enhanced lipolysis [121].…”

Section: Miscellaneous Activitiesmentioning

confidence: 99%

Perspectives on Medicinal Properties of Mangiferin

Vyas

Syeda

Ahmad

et al. 2012

MRMC

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Mango tree, Mangifera indica, has been cultivated in India and several other tropical countries for centuries, and it is a good source of compound 'mangiferin'. Mangiferin's xanthonoid structure with C-glucosyl linkage and polyhydroxy component is believed to be crucial for its free radical-scavenging ability leading to a potent antioxidant effect. A number of biological activities of mangiferin have been suggested, including antidiabetic and antiinflammatory abilities. These might be explained by its antioxidant ability as well as its ability to modulate several key inflammatory pathways. Mangiferin has also been shown to be an effective inhibitor of NF-κB signaling pathway. This partially explains its antiinflammatory ability and, additionally, points towards its anticancer potential. The anticancer effects of this compound are just beginning to emerge, and in this comprehensive review, we provide information on what we know about the chemistry and biological effects of mangiferin, which would likely create interest among researchers to design further mechanistic studies in order to better understand and exploit the biological activities of this compound.

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Antimicrobial Activity of Gentiana lutea L. Extracts

Cited by 45 publications

References 4 publications

Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats

Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats

An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Perspectives on Medicinal Properties of Mangiferin

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