Perspectives on Medicinal Properties of Mangiferin

Vyas, Alok; Syeda, K.; Ahmad, Aamir; Padhyé, Subhash; Sarkar, Fazlul H.

doi:10.2174/138955712800493870

Cited by 87 publications

(65 citation statements)

References 99 publications

(114 reference statements)

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“…Also, it is capable of eliciting broad spectrum beneficial biological effects, like analgesic, antipyretic, immunomodulator, antiviral, anthelmintic, antiallergic, antihistaminic, cardioprotective and antiamoebic, by modulating multiple targets [87].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Mangiferin: a promising anticancer bioactive

Khurana

Kaur

Lohan

et al. 2016

Pharmaceutical Patent Analyst

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Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, i.e., oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of Mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of Mangiferin.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Mangiferin: a promising anticancer bioactive

Khurana

Kaur

Lohan

et al. 2016

Pharmaceutical Patent Analyst

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show abstract

“…This compound exerts central nervous system-stimulating, anti-oxidant, analgesic, anti-inﬂammatory, and anti-diabetic activities [16]. In animal models, mangiferin (MA) treatment ameliorates oxidation in fatty liver [17], protects against lipopolysaccharide (LPS)-induced depressive and anxiety-like behavior in mice [18], and prevents the progression of inﬂammatory diseases such as colitis [19].…”

Section: Introductionmentioning

confidence: 99%

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

Peng

Zhu

et al. 2014

Am J Nephrol

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Background: Acute kidney injury (AKI) is a frequent and serious complication of sepsis. A growing body of evidence now suggests that inflammatory reactions and tubular dysfunction induced by oxidative stressinvolved in the mechanisms of the disease. This study aimed to determine the role of anti-inflammatory and anti-oxidant activities of mangiferin (MA) in sepsis-induced AKI. Methods: We investigated the effects of MA on apoptosis of rat kidney proximal tubular cell (RPTC), together with renal function and morphological alterations of mice undergoing cecal-ligation and puncture (CLP). The levels of oxidative stress in kidney tissues were also determined. Moreover, we mainly focus on the effects of MA in regulating the production of NLRP3 and Nrf2 in the present study. Results: The exposure to LPS (5 Vg/ml) yielded a signiﬁcant increase of apoptosis in RPTC cells, which was largely inhibited by MA pretreatment. MA attenuates renal dysfunction and ameliorates the morphological changes in the septic mice induced by CLP. MA inhibits oxidative stress, decreases serum levels of IL-1F and IL-18, and prevents tubular epithelial cells apoptosis in kidneys of CLP mice model. Data in this study also suggest that MA promotes Nrf2 expression and suppresses renal NLRP3 inflammasome activation. Conclusion: In summary, MA protects against sepsis-induced AKI through NLRP3 inflammasome inhibition and Nrf2 up-regulation. Thus, the mangiferin could thus be a promising candidate for development of a multi-potent drug. i 2014 S. Karger AG, Basel

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“…Mango stem-bark aqueous extract has been reported to possess anti-inflammatory, analgesic and immunoprotective effects [2,3]. A number of biological activities of mangiferin have been suggested, including anti-diabetic and anti-inflammatory abilities [4].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

El-Gied¹,

Joseph²,

Mahmoud³

et al. 2012

AiM

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Mangifera indica L. is a species of mango in the Anacardiaceae family. It is found in the wild in tropical regions and cultivated varieties have been introduced to other warm regions of the world. This present study aimed to investigate the in vitro antimicrobial activities of methanol and ethanol extracts of mango seed against 25 representatives gram positive, gram negative, acid fast bacteria and fungi. Mango fruit seed were extracted by Soxhlet using methanol and ethanol as solvents. The extracts were tested against the microorganisms using disc diffusion method at different concentrations: 5 mg/mL, 3.75 mg/mL, 3.125 mg/mL, 2.5 mg/mL, 1.875 mg/mL and 1.25 mg/mL). In vitro antibacterial activities of methanol and ethanol extracts of mango bulb showed inhibitions to tested organisms with variable inhibition zones. Except one organism (Rhodococcus equi), no resistance among the tested strains was shown. The mean zone of inhibition produced ranged between 5 mm and 18 mm with 18 mm/Mycobacterium smegmatis showed the highest zone of inhibition. In most test strains comparable zones of inhibitions were noted for both methanol and ethanol extract. Candida albicans and Aspergilllus niger were both inhibited by the extracts. The methanol and ethanol extracts of mango seed showed good inhibitory effects against almost all tested strains. The inhibition zones produced by mango extract were less than those produced by standard positive control drug. This could be due to low diffusion rate of mango extract in agarose medium, a thing needed to be further investigated. The products are potential new antimicrobial therapy in the ethnopharmacology domain.

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Perspectives on Medicinal Properties of Mangiferin

Cited by 87 publications

References 99 publications

Mangiferin: a promising anticancer bioactive

Mangiferin: a promising anticancer bioactive

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)

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Perspectives on Medicinal Properties of Mangiferin

Cited by 87 publications

References 99 publications

Mangiferin: a promising anticancer bioactive

Mangiferin: a promising anticancer bioactive

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

Antimicrobial Activities of Seed Extracts of Mango (&lt;i&gt;Mangifera indica&lt;/i&gt; L.)

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Product

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Antimicrobial Activities of Seed Extracts of Mango (<i>Mangifera indica</i> L.)