Antimicrobial activity of gallic acid against food-related  Pseudomonas  strains and its use as biocontrol tool to improve the shelf life of fresh black truffles

Sorrentino, Elena; Succi, Mariantonietta; Tipaldi, Luca; Pannella, Gianfranco; Maiuro, Lucia; Sturchio, Marina; Coppola, Raffaele; Tremonte, Patrizio

doi:10.1016/j.ijfoodmicro.2017.11.026

Cited by 85 publications

(67 citation statements)

References 30 publications

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“…Recent studies have shown high antioxidant and antimicrobial properties for gallic acid in particular, and higher nematocidal activity for extracts particularly rich in free gallic acid has also been observed [ 88 , 89 ]; thus, it is of interest to test new agronomical formulations containing oil extraction residue from grape seeds: these formulations could slowly release condensed tannins into the ground to obtain antimicrobial and nematostatic/nematicidal effects.…”

Section: A Grape Seed Biorefinery: a Picture Of Italian Experiencementioning

confidence: 99%

Bio-Based Compounds from Grape Seeds: A Biorefinery Approach

Lucarini¹,

Durazzo²,

Romani

et al. 2018

Molecules

100

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Food and agricultural waste represents a growing problem with negative effects on the economy, environment, and human health. Winemaking produces byproducts with high added value, which can be used for new productions in several application fields. From the perspective of biorefinery and circular economy, grape seeds could be exploited by extracting bioactive compounds with high added value before using biomass for energy purposes. The markets concerned are, in addition to the food, cosmetics, and pharmaceuticals sectors, which use bioactive compounds, the sector of biopolymeric materials and of energy for the production of biohydrogen and biomethane. Generally, bioactive components should be investigated through an integrated and multidisciplinary study approach based on emerging analytical techniques; in this context, attention is addressed towards green and sustainable procedures; an update of extraction techniques, innovative technologies, and chemometrics are described. Nowadays, processes so far tested on a pilot scale for grape waste are developed to enhance the extraction yields. Here, a picture of the Italian experience applied to the byproducts of the wine industry is given.

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Section: A Grape Seed Biorefinery: a Picture Of Italian Experiencementioning

confidence: 99%

Bio-Based Compounds from Grape Seeds: A Biorefinery Approach

Lucarini¹,

Durazzo²,

Romani

et al. 2018

Molecules

100

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“…Gallic acid (3,4,5-trihydroxybenzoic acid; GA), a natural phenolic compound, is widely distributed in natural plants, fruits, and green tea [9,10]. Many studies have reported that GA exhibits anti oxidative, anti mutagenic, anti carcinogenic, antibacterial, antiviral, and anti-inflammatory effects [11][12][13][14][15]. However, the main interest in GA and its derivatives surrounds its anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells

Kang

et al. 2020

Cancers

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Non-small-cell lung cancer (NSCLC) is the most common lung cancer subtype and accounts for more than 80% of all lung cancer cases. Epidermal growth factor receptor (EGFR) phosphorylation by binding growth factors such as EGF activates downstream prooncogenic signaling pathways including KRAS-ERK, JAK-STAT, and PI3K-AKT. These pathways promote the tumor progression of NSCLC by inducing uncontrolled cell cycle, proliferation, migration, and programmed death-ligand 1 (PD-L1) expression. New cytotoxic drugs have facilitated considerable progress in NSCLC treatment, but side effects are still a significant cause of mortality. Gallic acid (3,4,5-trihydroxybenzoic acid; GA) is a phenolic natural compound, isolated from plant derivatives, that has been reported to show anticancer effects. We demonstrated the tumor-suppressive effect of GA, which induced the decrease of PD-L1 expression through binding to EGFR in NSCLC. This binding inhibited the phosphorylation of EGFR, subsequently inducing the inhibition of PI3K and AKT phosphorylation, which triggered the activation of p53. The p53-dependent upregulation of miR-34a induced PD-L1 downregulation. Further, we revealed the combination effect of GA and anti-PD-1 monoclonal antibody in an NSCLC-cell and peripheral blood mononuclear–cell coculture system. We propose a novel therapeutic application of GA for immunotherapy and chemotherapy in NSCLC.

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“…As a consequence, several plant polyphenolic antioxidants, that proved to be more efficient and more thermally stable than top synthetic ones, were considered as safer and more capable alternatives and they were introduced into the food industry. Among natural occurring polyphenols, gallic acid (GA) (Figure .a) is able to exert antioxidant activity also in emulsion or lipid systems and in the form of propyl or butyl ester derivatives, it is used in processed foods, cosmetics and food packing materials to prevent rancidity induced by lipid peroxidation and spoilage …”

Section: Introductionmentioning

confidence: 99%

Assessment of the Efficiency of a Nanospherical Gallic Acid Dendrimer for Long‐Term Preservation of Essential Oils: An Integrated Chemometric‐Assisted FTIR Study

2019

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Essential oils (EOs) are volatile chemicals very popular in the food, cosmetic and pharmaceutical industry as aromas, fragrances and alternative therapeutic devices. EOs are susceptible to oxidative degradation, loss of quality and alterations of sensory and pharmacological properties with production of smelly or harmful compounds, responsible for allergic reactions. For preventing EOs’ spoilage, synthetic preservatives are adopted, but with poor efficiency and danger of health diseases. Natural polyphenols as gallic acid (GA) are proposed as safer alternatives, but the low compatibility with oils limits their efficacy. In this study, a hydrophobic, GA‐enriched antioxidant dendrimer (GAD), is advised as an innovative preservative, after due evaluations. Besides oxidation chemical indexes, the desired information was obtained by FTIR spectroscopy assisted by multivariate analysis. For further confirmation, FTIR data were interpreted by considering the area of some selected bands. Iodometric titration, was performed to determine peroxide value (PV), selected as chemical index. GAD showed a preservative power extraordinary better than that of GA and no pro‐oxidant action.

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Antimicrobial activity of gallic acid against food-related Pseudomonas strains and its use as biocontrol tool to improve the shelf life of fresh black truffles

Cited by 85 publications

References 30 publications

Bio-Based Compounds from Grape Seeds: A Biorefinery Approach

Bio-Based Compounds from Grape Seeds: A Biorefinery Approach

The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells

Assessment of the Efficiency of a Nanospherical Gallic Acid Dendrimer for Long‐Term Preservation of Essential Oils: An Integrated Chemometric‐Assisted FTIR Study

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