Antimicrobial activity of FeIII, CuII, AgI, ZnII and HgII complexes of 2-(2-hydroxy-5-bromo/nitro-phenyl)-1H- and 2-(2-hydroxyphenyl)-5-methyl/chloro/nitro-1H-benzimidazoles

Abstract

Antimicrobial activity of 2-(2-hydroxyphenyl)-5-R5-1H-benzimidazoles, 2-(2-hydroxy-5-R5'-phenyl)-1H-benzimidazoles and their FeIII, CuII, AgI, ZnII and HgII nitrate complexes was tested toward Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, and Proteus mirabilis. Antifungal activity was tested against Candida albicans. Benzimidazole benzene ring substituents increase the antimicrobial activity, phenol ring substituents decrease it. The ligands show an antibacterial effect against only S. aureus whereas AgI and HgII complexes of the ligands have a higher activity with respect to the other complexes to all the bacteria. On the other hand, FeIII complexes show a considerable activity against S. aureus and S. epidermidis.

Synthesis, structure and biological activities of cobalt(II) and zinc(II) coordination compounds with 2-benzimidazole derivatives

“…Coordination compounds of benzimidazole derivatives with transition metal ions have been used to prepare structural and spectroscopic models of the active sites of some metalloenzymes [18], but the investigation concerned with their biological activity has been limited to thiabendazole coordination compounds with Co(II), Cu(II), Ni(II) and Zn(II) [6,19] and 2-substituted pyridinyl derivatives of Fe(III), Co(II), Zn(II), Ag(I) and Hg(II) [20][21][22].…”

Potential of silver nanoparticle‐coated polyurethane foam as an antibacterial water filter

“…To achieve this, chemical and physical agents, such as chlorine and its derivatives, AgNO 3 , ultraviolet light and radiation, are commonly used (Droste, 1997). During the past few decades, several investigations have been carried out concerning the use of synthetic and natural zeolites, polymer films, and metal ions (Ag, Cu, Zn, Hg, Ti, Ni, Co) as bactericides for water disinfection (Feng et al, 2000;Shearer et al, 2000;McLean et al, 1993;Chohan et al, 2004;Ulkuseven et al 2002;Chen et al, 2003;Cik et al, 2001;Islam et al, 2003). The use of metal nanoparticles for water disinfection is relatively new (Stoimenov et al, 2002;Zhang et al, 2003).…”

Antibacterial Effect of Lanthanum Calcium Manganate (La<SUB>0.67</SUB>Ca<SUB>0.33</SUB>MnO<SUB>3</SUB>) Nanoparticles Against Pseudomonas aeruginosa ATCC 27853

“…[2][3] Nowadays, several techniques have been evolved for treatment of water i.e., chemical and physical agent including synthetic and natural zeolites, polymer films, and metal ions (Ag + , Cu ++ , Zn ++ , Hg ++ , Ti +++ , Ni ++ , Co ++ as bactericides for water disinfection. [4][5][6][7][8][9][10][11] Over the past few decades, inorganic nanoparticles exhibiting significantly novel physical, chemical, and biological properties and functionality due to their size, have elicited much interest. Nanostructured materials are taking attention because of their potential for achieving specific processes and selectivity, especially in biological and pharmaceutical applications.…”