Antimicrobial activity of essential oil and aqueous and ethanol extracts of Teucrium polium L. subsp. gabesianum (L.H.) from Tunisia

Othman, Mahmoud Ben; Salah, Karima Bel Hadj; Ncibi, Saida; Elaissi, Amer; Zourgui, Lazhar

doi:10.1007/s12298-017-0444-9

Cited by 21 publications

(32 citation statements)

References 31 publications

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“…Similar results were obtained using the same solvent and the aerial parts of felty germander—the yield of extraction was 8.24% [ 46 ]. Previous studies reported different yields of extraction using organic solvents with different polarities, and different T. polium organs [ 47 , 48 , 49 , 50 ]. In fact, using ethanol (50%) and the T. polium aerial parts, the yield of extraction was 12.5% [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…The antibacterial activity of aerial parts’ methanolic extract of T. polium is directly linked to their phytoconstituents and contingent by the activity of their chemical compounds and their proportion in the extract. Many studies evaluated the antibacterial activity of the essential oil of T. polium [ 29 , 50 ]. The essential oils, aqueous, and ethanol extracts of T. polium exhibited high antibacterial activity, against both Gram-negative and positive bacteria and antifungal properties [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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The chemical profile of Teucrium polium L. (T. polium) methanolic extract was tested using liquid chromatography coupled with high resolution mass spectrometry (HR-LCMS). Disc diffusion and microdilution assays were used for the antimicrobial activities. Coxsackievirus B-3 (CVB3) and Herpes simplex virus type 2 (HSV-2) were used for the antiviral activities. Chromobacterium violaceum (ATCC 12472 and CV026) and Pseudomonas aeruginosa PAO1 were used as starter strains for the anti-quorum sensing tests. Isoprenoids are the main class of compounds identified, and 13R-hydroxy-9E,11Z-octadecadienoic acid, valtratum, rhoifolin, sericetin diacetate, and dihydrosamidin were the dominant phytoconstituents. The highest mean diameter of growth inhibition zone was recorded for Acinetobacter baumannii (19.33 ± 1.15 mm). The minimal inhibitory concentrations were ranging from 6.25 to 25 mg/mL for bacterial strains, and from 6.25 to 25 mg/mL for Candida species. The 50% cytotoxic concentration on VERO (African Green Monkey Kidney) cell lines was estimated at 209 µg/mL. No antiviral activity was recorded. Additionally, T. polium extract was able to inhibit P. aeruginosa PAO1 motility in a concentration-dependent manner. However, the tested extract was able to inhibit 23.66% of the swarming and 35.25% of swimming capacities of PAO1 at 100 µg/mL. These results highlighted the role of germander as a potent antimicrobial agent that can interfere with the virulence factors controlled by the quorum-sensing systems.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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“…Antimicrobial effects of these compounds depend on the number and the position of the phenol hydroxyl groups. It has been claimed that the toxicity effect of these compounds on the microorganisms is directly correlated with the numbers of hydroxyl groups [33]. Another antimicrobial component existing in T. polium herb is tannin compound.…”

Section: Discussionmentioning

confidence: 99%

The effect of antimicrobial activity of Teucrium Polium on Oral Streptococcus Mutans: a randomized cross-over clinical trial study

et al. 2020

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Background: The purpose of this study is to determine the effect of a mouthwash containing Teucriumpolium herb on Streptococcus mutans in mouth. Methods: This study was a randomized, crossover, double-blind clinical trial, where we selected 22 volunteers (dental students) randomly and we divided them into two groups. The study had two phases. In each phase, one group acted as the intervention group, while the other one was the control group. Both the intervention and control groups were given the mouthwash with and without Teucriumpolium, respectively. S. mutans of saliva were measured before and after each phase to compare the effects of the mouthwashes. A three-week washout period was considered between the two phases. An independent two-sample t-test was utilized to compare the mean of S. mutans colonies. Additionally, we used a standard AB/BA crossover model to find the results of the treatment and the impact of carryover on the residual's biological effects. The significance level was considered 0.05 in this experiment. Results: There is no significant difference observed between the two groups in the number of S. mutans before using the mouthwashes. When the mouthwash containing Teucriumpolium was used, there was a significant decrease in the number of S. mutans colonies in both phases' extract (P = 0.002). Conclusion: The results of this study indicate the mouthwash containing aqueous extract of Teucrium polium can majorly reduce the colonization of S. mutans in human saliva. Trial registration: Ethical issues approved by the Ethics Committee of the Rafsanjan University of Medical Sciences with the approval number of 937/9/31, IRCT code Number of IRCT2013121815842N1 and it was approved on 06/ 16/2014. The study was conducted in the period of September to November 2014.

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“…[32] Antimicrobial effects of these compounds depend on the number and the position of the phenol hydroxyl groups. It has been claimed that the toxicity effect of these compounds on the microorganisms is directly correlated with the numbers of hydroxyl groups [33]. Another antimicrobial component existing in T. polium herb is tannin compound.…”

Section: Discussionmentioning

confidence: 99%

Effect of antimicrobial activity of Teucrium polium on oral Streptococcus mutans: a randomized cross-over clinical trial study

Tusi

Jafari

Marashi

et al. 2020

Preprint

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Background : The purpose of this study was to determine the effect of a mouthwash containing Teucrium polium herb on Streptococcus mutans in mouth. Methods : This study was a randomized, crossover, double-blind clinical trial, where twenty-two volunteer dental students were randomly divided into two groups. The study had two phases. In each phase, one group was chosen as the intervention group, while the other one was the control group. Both the intervention and control groups were given the mouthwash with and without Teucrium polium , respectively. S. mutans of saliva were measured before and after each phase to compare the effects of the mouthwashes. A three-week washout period was considered between the two phases. An independent two-sample t-test was used to compare the mean number of S. mutans colonies. Additionally, a standard AB/BA crossover model was used to find the results of the treatment and the carryover effect on the residual biological effects. The significance level was considered 0.05 in this experiment. Results : There was no significant difference between the two groups in the number of S. mutans before using the mouthwashes. Using the mouthwash containing Teucrium polium extract significantly decreased the number of S. mutans colonies in both phases (P = 0.002). Conclusion : The results of this study showed that the mouthwash containing aqueous extract of Teucrium polium can significantly reduce the colonization of S. mutans in human saliva. Trial registration : Ethical issues approved by the Ethics Committee of the Rafsanjan University of Medical Sciences with the approval number of 937/9/31 and IRCT code No. IRCT2013121815842N1, approved in 06.16.2014. The study was done in September till November 2014.

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Antimicrobial activity of essential oil and aqueous and ethanol extracts of Teucrium polium L. subsp. gabesianum (L.H.) from Tunisia

Cited by 21 publications

References 31 publications

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

The effect of antimicrobial activity of Teucrium Polium on Oral Streptococcus Mutans: a randomized cross-over clinical trial study

Effect of antimicrobial activity of Teucrium polium on oral Streptococcus mutans: a randomized cross-over clinical trial study

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