Antimicrobial Activity of Electrospun Poly(butylenes succinate) Fiber Mats Containing PVP-Capped Silver Nanoparticles

Poly(alkylene dicarboxylate)s constitute a family of biodegradable polymers with increasing interest for both commodity and speciality applications. Most of these polymers can be prepared from biobased diols and dicarboxylic acids such as 1,4-butanediol, succinic acid and carbohydrates. This review provides a current status report concerning synthesis, biodegradation and applications of a series of polymers that cover a wide range of properties, namely, materials from elastomeric to rigid characteristics that are suitable for applications such as hydrogels, soft tissue engineering, drug delivery systems and liquid crystals. Finally, the incorporation of aromatic units and α-amino acids is considered since stiffness of molecular chains and intermolecular interactions can be drastically changed. In fact, poly(ester amide)s derived from naturally occurring amino acids offer great possibilities as biodegradable materials for biomedical applications which are also extensively discussed.

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“…Bacterial growth was found to be inhibited for a long period of time due to the long-term release performance of Ag from these fiber mats [203]. …”

Section: Applications Of Poly(alkylene Dicarboxylate)smentioning

confidence: 99%

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

Díaz

Katsarava

Puiggalı́

2014

IJMS

208

112

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“…2a). Poly(butylene succinate) mats containing small (<10 nm) silver nanoparticles were also be prepared using PVP as capping reducing agent 29 and even the electrospinning solvent was proposed to reduce silver with the electrospinning polymer acting as stabilizing agent. 30 The same results were reported for composite PCL nanofibers with silver particles precipitated onto their surface.…”

Section: Antimicrobial Materialsmentioning

confidence: 99%

Bioactive Applications for Electrospun Fibers

2016

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Electrospinning is a versatile technique providing highly tunable nanofibrous nonwovens. Many biomedical applications have been developed for nanofibers, among which the production of antimicrobial mats stands out. The production of scaffolds for tissue engineering, fibers for controlled drug release, or active wound dressings are active fields of research exploiting the possibilities offered by electrospun materials. The fabrication of materials for active food packaging or membranes for environmental applications is also reviewed. We attempted to give an overview of the most recent literature related with applications in which nanofibers get in contact with living cells and develop a nano-bio interface.

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“…Poly(butylene succinate) (PBS) is a commercially available biocompatible, biodegradable, and easy-processing aliphatic polyester. [30][31][32][33][34] In a preliminary work, we found that PBS electrospun membrane has very good hydrophilicity. It can quickly absorb water, facilitating drug loading and hemostasis.…”

Section: Introductionmentioning

confidence: 99%

Thrombin‐Loaded Poly(butylene succinate)‐Based Electrospun Membranes for Rapid Hemostatic Application

Cheng

Xiong

Xie

et al. 2017

Macro Materials & Eng

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Poly(butylene succinate) (PBS) and gelatin‐coated PBS electrospun membranes are evaluated for use as support materials to immobilize thrombin, an effective hemostat for topical injury, and three methods differing in whether and when gelatin is included are envisaged to prepare thrombin‐loaded PBS‐based electrospun membranes for use as rapid hemostatic materials. Both PBS and gelatin‐coated PBS membranes have high porosity, excellent wettability, rapid water penetration rate, and high water uptake, and thus are suitable support materials for thrombin. The thrombin immobilized onto gelatin‐coated PBS membrane has both high initial enzyme activity and high storage stability ascribed to the stabilizing effect of gelatin on thrombin activity. The hemostasis performance of thrombin‐immobilized membrane is evaluated in a rat liver model, showing shorter hemostasis time and less blood loss than clinically used gelatin sponge. The hemostasis mechanism is attributed to combined effects of thrombin and porous structure of electrospun membrane.

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Antimicrobial Activity of Electrospun Poly(butylenes succinate) Fiber Mats Containing PVP-Capped Silver Nanoparticles

Cited by 40 publications

References 36 publications

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

Bioactive Applications for Electrospun Fibers

Thrombin‐Loaded Poly(butylene succinate)‐Based Electrospun Membranes for Rapid Hemostatic Application

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