Antimicrobial activity of crude extracts of three medicinal plants used in South-West Nigerian folk medicine on some food borne bacterial pathogens

Akinyemi, Kabiru Olusegun; Oluwa, O.; Omomigbehin, EO

doi:10.4314/ajtcam.v3i4.31173

Cited by 80 publications

(73 citation statements)

References 30 publications

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“…The tubes were observed after 24 hours of incubation to determine minimum inhibitory concentration. That is the lowest concentration that showed no evidence of growth (Akinyemi et al, 2005;Vallekobia et al, 2001). …”

Section: (E) Micro-broth Dilution Technique (I) Minimum Inhibitory Comentioning

confidence: 99%

“…1 filter paper, sterilized in Bijou bottles by autoclaving at 121 o C for 15mins. Sensitivity discs were prepared by weighing the appropriate amount of the extract or fraction and serial doubling dilution in Dimethylsulfoxide (DMSO) followed by placing the improvised paper discs in the solution such that each disc absorbed 0.01ml to make the disc potency of 500µg, 1000µg, 2000µg and 4000µg ( (Akinyemi et al, 2005;Vallekobia et al, 2001)). …”

Section: (Vii) Test For Tanninsmentioning

confidence: 99%

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In vitro sensitivity pattern of some urinary tract isolates to Carica papaya extracts

Yusha’u¹,

Onuorah²,

Murtala³

2011

Bayero J. Pure App. Sci.

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Powdered leaves of Carica papaya (L.) were extracted with ethanol and partitioned in chloroform and distilled water. The extract and fractions were tested for antibacterial activity against clinical isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas species using disc diffusion and microbroth dilution technique. The extract and fractions were further subjected to phytochemical tests for the presence of secondary metabolites using standard procedures. Results of sensitivity test results showed that ethanol extract of the leaf was active against E. coli and K. pneumoniae (7mm each) at 1000µg/disc concentration while chloroform and water fractions of the leaf were active against Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis at 1000µg/disc concentration with zone diameter of 7mm each. Both the extract and fractions were inactive against P. aeruginosa at all concentrations used in this study. The results of phytochemical screening indicated the presence of alkaloids, flavonoids, steroids and tannins in either ethanol extract, fraction(s) or both. This indicates that the Carica papaya has the potential for the production of drugs against organisms causing urinary tract infections.

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Section: (E) Micro-broth Dilution Technique (I) Minimum Inhibitory Comentioning

confidence: 99%

Section: (Vii) Test For Tanninsmentioning

confidence: 99%

In vitro sensitivity pattern of some urinary tract isolates to Carica papaya extracts

Yusha’u¹,

Onuorah²,

Murtala³

2011

Bayero J. Pure App. Sci.

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“…Saleh, (2015) experimented that products of higher plant origin have been known to be effective sources of chemotherapeutic agents without any underlying effects and they are the major source of medicines, as they have been throughout human history. Akinyemi et al (2006) reported that the use of medicinal plants all over the world predates the introduction of antibiotics and other modern drugs. A medicinal plant is any plant with one or more of its organs containing substances that can be used for therapeutic purposes or which are the precursors for the synthesis of useful drugs (Jahan, et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…A medicinal plant is any plant with one or more of its organs containing substances that can be used for therapeutic purposes or which are the precursors for the synthesis of useful drugs (Jahan, et al, 2011). They are of great importance to the health of individuals and communities; the medicinal values of certain plants lie in some chemical substances that produce definite physiological action on the human body (Akinyemi, et al, 2006, Jahan, et al, 2011). Bamisaye, et al (2013 noted that the most important of these bioactive constituents of plants are lavonoids, tannins, alkaloids and foods plants sometimes added to foods.…”

Section: Introductionmentioning

confidence: 99%

Carica Papaya- A Herbal Medicine

2016

International Journal of Research Studies in Biosciences

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“…RA is one of the leading causes of chronic morbidity in the developed world, and mostly affecting the work force population throughout the world (Mody, 2009). In developing countries, especially in tropical Africa, the use of traditional approach in the treatment of disease is still in practice (Akinyemi et al, 2006). Medicinal plant extracts are rich in phytoconstituents that have been used by man as prophylactic or therapeutic agent in the treatment of several inflammatory-related diseases (Balekar et al, 2013;Sofowora, 1993).…”

Section: Introductionmentioning

confidence: 99%

Hematological and lipid profile evaluation of a hexane fraction ofCostus aferleaves in arthritic rats

Anyasor

Onajobi

Osilesi

et al. 2015

Pharmaceutical Biology

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Context: Costus afer Ker Gawl. (Costaceae) is an ethnomedical plant used as therapy against inflammatory disorders. Objective: The objective of this study was to evaluate the hematological and lipid profile analysis of hexane fraction of C. afer leaves (CAHLF) in arthritic rats. Materials and methods: Male albino rats were randomly distributed into seven groups of six rats each. Rats were induced with arthritis using formaldehyde and Complete Freund's Adjuvant (CFA) for 7 and 21 d, respectively. The animals were administered orally with 50, 100, and 250 mg/kg CAHLF, 10 mg/kg diclofenac and prednisolone, 0.9% NaCl (control), and 0.9% NaCl (normal). At the end of treatment periods, blood samples were withdrawn and subjected to hematological and biochemical analysis using auto-analyzer and spectrophotometric methods. Results: Hematological analysis revealed that in formaldehyde-and CFA-induced arthritic rat models, 250 mg/kg CAHLF-treated groups had significantly reduced (p50.05) hematocrit counts (HC) (30.98 ± 1.59% and 33.55 ± 1.10%), white blood cell counts ( /L). Furthermore, blood analysis showed that CAHLF-treated groups had reduced total cholesterol, low-density lipoprotein cholesterol, and triglycerides while they had an elevated high-density lipoprotein compared with the control group. Discussion and conclusion: Findings from this study indicated that CAHLF could possess immunomodulatory and hypolipidemic properties in arthritic rats. CAHLF could be considered as a source of biopharmaceutical agents in anti-arthritis drug discovery process.

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Antimicrobial activity of crude extracts of three medicinal plants used in South-West Nigerian folk medicine on some food borne bacterial pathogens

Cited by 80 publications

References 30 publications

<i>In vitro</i> sensitivity pattern of some urinary tract isolates to <i>Carica papaya</i> extracts

<i>In vitro</i> sensitivity pattern of some urinary tract isolates to <i>Carica papaya</i> extracts

Carica Papaya- A Herbal Medicine

Hematological and lipid profile evaluation of a hexane fraction ofCostus aferleaves in arthritic rats

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