Antimicrobial activity of coupled hydroxyanthracenones isolated from plants of the genus Karwinskia

Atropisomeric Dihydroanthracenones as Inhibitors of Multiresistant Staphylococcus aureus

“…Further dimeric dihydroanthracene derivatives structurally related to 1 – 4 were previously reported from several higher plants including Bulbine abyssinica (Asphodelaceae), Cassia torosa, Cassia singueana, Cassia occidentalis (Fabaceae), Karwinskia humboldtiana and Karwinskia parvifolia (Rhamnaceae). , The biosynthesis of diverse natural products, originally only characterized from plants, by endophytic fungi has repeatedly been reported in the past decades. Well-known examples include paclitaxel, originally obtained from Taxus brevifolia and later reported from endophytic Taxomyces andreanae, and hypericin, reported from Hypericum perforatum and endophytic Thielavia subthermophila. ,− Hence, it is intriguing to speculate on the true origin of fungal dimeric dihydroanthracene derivatives such as those reported in this study based on the close structural resemblance of these natural products to known plant metabolites.…”

“…As both 3R and 3S configurations are reported for atrochrysone and torosachrysone monomers in the literature, 40−44 experiments to determine the central Further dimeric dihydroanthracene derivatives structurally related to 1−4 were previously reported from several higher plants including Bulbine abyssinica (Asphodelaceae), 45 Cassia torosa, 46 Cassia singueana, 47 Cassia occidentalis (Fabaceae), 48 Karwinskia humboldtiana 49 and Karwinskia parvifolia (Rhamnaceae). 50,51 The biosynthesis of diverse natural products, originally only characterized from plants, by endophytic fungi has repeatedly been reported in the past decades. Well-known examples include paclitaxel, originally obtained from Taxus brevifolia and later reported from endophytic Taxomyces andreanae, and hypericin, reported from Hypericum perforatum and endophytic Thielavia subthermophila.…”

Medicinal plants with significant activity against important pathogenic bacteria

“…The percentage of the population that has used some form of alternative medicine is 48% in Australia, 70% in Canada, 42% in the USA, 38% in Belgium, and 75% in France (WHO, 2002a). In addition, a number of recent studies have documented the antibacterial activities of various species of medicinal plants against several pathogenic bacteria (Singh et al, 2005;Zaidi & Crow, 2005;Al-hebshi et al, 2006;Moon et al, 2006;Salazar et al, 2006).…”

Unraveling the Adaptive Chemical Traits of Rhamnidium elaeocarpum in Response to Fire and Environmental Factors in Pantanal Wetlands

“…These metabolites have been extensively studied in Karwinskia, a genus closely related to Rhamnidium (Hauenschild et al, 2016;Richardson et al, 2004). Some hydroxyanthracenones have been shown to exhibit antimicrobial and antifungal activities (Salazar-Aranda et al, 1998;Salazar et al, 2006) and toxic properties (Bermudez et al, 1986;Martínez et al, 1997;Piñeyro-Lopez and Waksman, 2000;Rojas-Flores et al, 2014). This nding serves as a warning to the Pantanal population who have been using R. elaeocarpum barks for food and therapeutic purposes (Bieski et al, 2012;Bortolotto et al, 2018;Pott and Pott, 1994).…”