Antimicrobial Activity of Chelidonium Species Majus L.

Abstract

The present paper has as main objective the determination of the antimicrobial and antifungal activity of some pharmaceutical forms obtained in the laboratory of pharmaceutical technology of the Faculty of Pharmacy of the University "Lower Danube of Galati". We used semi-solid pharmaceutical forms with different concentrations of soft extract of Chelidonium majus L, 50%, 25% and 10% in two ointment bases, simple ointment and base III I performed the antimicrobial activity for all four ointments, compared to extract 1: 3.75 in hydroalcoholic solution (ethyl alcohol / water 35/65 by mass) from aerial parts of Chelidonium majus and alcohol 70 °. hydroalcoholic solution was obtained by cold preparation from the aerial parts of the plant Chelidonium majus. We determined the antimicrobial activity by the diffusimetric method (Kirby-Bauer) and the dilution method. The 50% concentration ointment (UNG A) shows activity on some Gram-negative and Gram-positive bacteria and not on the fungus Candida albicans.

Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

“…Numerous research studies have been conducted on the chemical composition and pharmacological activity of Chelidonium majus . Most of these studies have focused on specific phytoconstituent categories found in certain parts of the plant [ 3 , 4 , 5 , 6 , 7 , 8 , 10 , 30 , 31 , 32 ].…”

“…Paracelsus mentioned the benefits of this plant for treating hepato-biliary conditions. Currently, greater celandine is appreciated in traditional European medicine, especially in the central and eastern regions, being recognized for its exceptional therapeutic properties, especially in dermatological conditions (e.g., eczema, verrucae, circumscribed cutaneous carcinomas), hepato-biliary (anti-jaundice) conditions, chole cytopathies, biliary lithiasis, gastrointestinal spasms, eye infections, and inflammation [ 3 , 4 , 5 , 6 ]. Modern research has reported the presence of a large variety of biomolecules (alkaloids, flavonoids, carotenoids, lectins, phenolic acids, volatile oils, and others) and, thus, remarkable biological activity (antibacterial, antimicrobial, antifungal, antiviral, anti-inflammatory, antitumoral, anti-spasmodic, hepato-protective, analgesic, and immunomodulatory) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”