Antimicrobial activity of Brazilian copaiba oils obtained from different species of the Copaifera genus

Santos, Adriana O.; Ueda-Nakamura, Tânia; Filho, Benedito Prado Dias; Veiga, Valdir Florêncio da; Pinto, Ângelo C.

doi:10.1590/s0074-02762008005000015

Cited by 162 publications

(177 citation statements)

References 18 publications

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“…Used since the 16th century for medicinal purposes 2,6 , Copaíba oil is described in the literature as anti-edematous 5 , anti-inflammatory 3,7,8 , antibacterial 8,9 , insecticide 5,6,8 , antifungal 10 and wound healing 8,11 . It is popularly adopted in the treatment of several diseases, such as cystitis, bronchitis, chronic diarrhea, rheumatism, psoriasis, tumors 9 and gonorrhea 4 .…”

Section: Officinaliis C Reticulata C Langsdorffii C Guyanensismentioning

confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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Objectives: to evaluate, histologically and macroscopically, the influence of Copaifera multijuga (Copaíba) oil-resin on the healing process of cutaneous wounds, comparing it with nitrofurazone. Methods: we divided 36 rats into three groups of 12 animals, according to the treatment to be administered. Group SL (control) received saline on the lesion; the Group OIL received topical treatment with Copaíba oil; and the Group NITRO was treated with Nitrofurazone. We inflicted a circular wound of 8mm in diameter on the back of each animal. We subdivided each of the three groups of 12 animals into three subgroups, according to treatment time and euthanasia (7, 14 and 21 days). All animals received the proposed treatment daily. We photographed the lesions for area measurement, as well as for evaluation of macroscopic aspects. We resected and stained the scars to quantify and qualify elastic fibers, collagen, degree of epithelization, neovascularization and inflammation. Results: although the saline solution provided a faster wound closure in its initial phase, after 14 days the wound size of the three groups tested was the same. Levels of inflammation and neovascularization were similar in all three groups. The amount of collagen and elastic fibers was higher in the Nitrofurazone and Copaíba oil groups. Conclusion: in male Wistar rats, Copaifera multijuga oil-resin positively influences the healing process, but it is less effective than nitrofurazone in healing by secondary intention.

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Section: Officinaliis C Reticulata C Langsdorffii C Guyanensismentioning

confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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“…Classification of the antibacterial activity was based on MIC values, as follows: MIC < 100 mg/mL, good; 100 < MIC < 500 mg/mL, moderate; 500 < MIC < 1000 mg/mL, weak; MIC > 1000 mg/mL, inactive [23]. Most of the evaluated extracts were inactive or weakly active against the panel of selected oral bacteria ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

Screening of Selected Plant-Derived Extracts for Their Antimicrobial Activity against Oral Pathogens

Crotti¹

2017

IJCAM

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Background: Dental caries is a major public health concern that affects the populations of many countries worldwide. In this paper, we screened twenty-four plant-derived extracts for their antimicrobial activity against a representative panel of cariogenic bacteria. Methods:The leaves of each species were dried, powdered and sequentially extracted with n-hexane, dichloromethane and methanol under Sonication for 5 min. The minimum inhibitory concentration (MIC) values of the resulting extracts were determined by using the broth micro dilution method in 96-well micro plates. Chlorhexidine was used as positive control. The chemical composition of the most active extract was determined by gas chromatography -mass spectrometry (GC-MS). Results:The n-hexane extract of P. neochilus (PN-Hex) afforded the lowest MIC values against S. mitis (MIC = 31.2μg/mL), S. mutans (MIC = 31.2μg/mL), S. sanguinis (MIC = 31.2μg/mL), S. salivarus (MIC = 62.5μg/mL), S. sobrinus (MIC = 62.5μg/mL), E. faecalis (MIC = 62.5μg/mL) and L. casei (MIC = 250μg/mL). GC-MS analysis of this extract revealed that spathulenol (46.1 %), trans-caryophyllene (19.0 %), caryophyllene oxide (10.7 %) and germacrene D (7.8 %) were the major constituents in PN-Hex. Conclusion:The n-hexane extract of P. neochilus (PN-Hex) displays promising antimicrobial activity against some cariogenic bacteria. Our results suggest that this extract might be promising for the development of new oral care products.

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“…Knowing that the copaiba used in this study does not show effects against gram-negative bacteria 13 and that the model of CLP primarily deflagrates gramnegative septicemia, it is believed that the determining factor for increasing animal survival was the anti-inflammatory action of this plant, by modulating the inflammatory response and subsequent issue damage mediated by free radicals and proinflammatory citocinais against sepsis.…”

Section: Discussionmentioning

confidence: 97%

“…One of the main medicinal plants used in the Amazon region, and the subject of many scientific studies is the copaiba oils, whose effects were tested and found effective in various activities, such as anti-inflammatory and antimicrobial 12 , especially against gram-positive bacteria 13 .…”

Section: Introductionmentioning

confidence: 99%

Copaiba oil effect under different pathways in mice subjected to sepsis

Botelho

Silveira²,

Lopes

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed.The Kaplan-Meier curves of surviving time were realized. RESULTS:All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05) CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.

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Antimicrobial activity of Brazilian copaiba oils obtained from different species of the Copaifera genus

Abstract: The antimicrobial activity of copaiba oils was tested against Gram-positive and Gram-negative bacteria, yeast, and

Cited by 162 publications

References 18 publications

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Screening of Selected Plant-Derived Extracts for Their Antimicrobial Activity against Oral Pathogens

Copaiba oil effect under different pathways in mice subjected to sepsis

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