Antimicrobial activity of benzylisoquinoline alkaloids from Annona salzmanii D.C.

Paulo, Marçal de Queiroz; Barbosa-Filho, JoséM.; Lima, Edeltrudes O.; Maia, Ricardo Fernandes; Cássia, Rita de; Junior, Bernardo Barbosa; Kaplan, Maria Auxiliadora Coelho

doi:10.1016/0378-8741(92)90058-y

Cited by 53 publications

(9 citation statements)

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“…Compounds isolated from the stem bark of Beilschmiedia anacardioides showed activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis [ 36 ]. Phytochemical studies of several species of Beilschmiedia genus revealed the presence of antibacterial compounds such as alkaloids [ 37 ], flavonoids [ 38 , 39 ] and phenolics, and related compounds [ 40 ]. These compounds could explain the bactericidal activity of B. mannii where inhibitory diameters (10–15 mm) found with the extracts were the closest to those of gentamicin (20–29 mm) and tetracycline (17–30 mm) .…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial potential of 27 plants consumed by chimpanzees (Pan troglodytes verus Blumenbach) in Ivory Coast

Ahoua¹,

Konan²,

Bonfoh³

et al. 2015

BMC Complement Altern Med

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BackgroundDue to their genetic proximity, chimpanzees share with human several diseases including bacterial, fungal and viral infections, such as candidiasis, acquired immune deficiency syndrome (AIDS), Ebola virus disease. However, in its natural environment, chimpanzees are tolerant to several pathogens including simian immunodeficiency virus (SIV), virus related to human immunodeficiency virus (HIV) that contribute to the emergence of opportunistic diseases such as microbial infections.MethodsTwenty seven species of plants consumed by chimpanzees were evaluated for their antimicrobial potential against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Candida tropicalis and Candida glabrata using the agar diffusion technique and micro-dilution in 96-well plates. In total 132 extracts (33 dichloromethane, 33 methanol, 33 ethyl acetate and 33 aqueous) were tested.ResultsThe results showed that 24 extracts (18 %) showed activity against bacteria and 6 extracts (5 %) were active against yeasts. The minimal inhibitory concentrations (MICs) values of active extracts ranged between 23 and 750 μg/ml for bacteria and between 188 and 1500 μg/ml for yeasts.ConclusionTristemma coronatum was the most promising on the studied microorganisms followed by Beilschmiedia mannii. The extracts of the two plants indicated by chimpanzees have potential for antimicrobial use in human.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial potential of 27 plants consumed by chimpanzees (Pan troglodytes verus Blumenbach) in Ivory Coast

Ahoua¹,

Konan²,

Bonfoh³

et al. 2015

BMC Complement Altern Med

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“…Alkaloids isolated from this extract boldine ( 74 ), 2-hydroxy-9-methoxyaporphine ( 81 ), laurotetanine ( 82 ), secoboldine ( 89 ), isoboldine ( 80 ), asimilobine ( 83 ), oreobeiline ( 87 ), 6-epioreobeiline ( 88 ), liriodenine ( 90 ), ( S )-3-methoxynordomesticine ( 91 ) and the triterpenoid β-amyrone ( 174 ) exhibited good antifungal activity against the same strain with MICs in the range of 8–64 μg/mL [ 29 ]. Paulo and collaborators reported moderate antifungal activity for laurelliptine ( 79 ) and isoboldine ( 80 ) in vitro against Tricophyton rubrum and Microsporum gypseun [ 101 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

et al. 2015

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Plants of the Lauraceae family are widely used in traditional medicine and are sources of various classes of secondary metabolites. Two genera of this family, Beilschmiedia and Endiandra, have been the subject of numerous investigations over the past decades because of their application in traditional medicine. They are the only source of bioactive endiandric acid derivatives. Noteworthy is that their biosynthesis contains two consecutive non-enzymatic electrocyclic reactions. Several interesting biological activities for this specific class of secondary metabolites and other constituents of the two genera have been reported, including antimicrobial, enzymes inhibitory and cytotoxic properties. This review compiles information on the structures of the compounds described between January 1960 and March 2015, their biological activities and information on endiandric acid biosynthesis, with 104 references being cited.

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“…In a study conducted by Maqal de Q. Pauloa, et al . on antimicrobial activities of benzylisoquinoline alkaloids, bark of Annona salzmarzii from Annonaceae family, yielded four benzylisoquinoline alkaloids, including reticuline, anonaine, laureiliptine and isoboldine of which anonaine, an isoquinoline alkaloid with aporphine core structure, showed moderate antibacterial properties and others showed antifungal activities ( 23 ). In a similar study by Villar A, et al .…”

Section: Discussionmentioning

confidence: 99%

Bioassay-directed isolation of quaternary benzylisoquinolines from Berberis integerrima with bactericidal activity against Brucella abortus

et al. 2018

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Berberis integerrima Bonge. (Syn: Berberis densiflora Boiss. & Buhse) is a shrub widely distributed in Middle East and central part of Asia. An ethnobotanical study revealed that indigenous and tribal people in Iran use B. integerrima root decoction for treatment of brucellosis. Therefore, the aim of this study was bioassay directed isolation of antibacterial compounds from this plant based on their in vitro bactericidal activity against Brucella abortus. Briefly, the ethanol extract of B. integerrima was fractioned and subjected to preliminary antibacterial screening tests against Brucella. The more active fraction (Fr.3) was subjected to purification by repeated chromatography systems. Quaternary benzylisoquinoline alkaloids including columbamine, palmatine, berberine, and jatrorhizine were four main components identified in the selected active fraction. Except for berberine which is reported before, palmatine, columbamine and jatrorhizine are isolated for the first time from this plant. Anti-brucellosis properties of isolated compounds 1-4 were studied against B. abortus under different test conditions. In minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) results, jatrorhizine (4) showed more antibacterial activity with MIC and MBC of 0.78 and 1.56 μg/mL, respectively. In both agar well diffusion and disk diffusion ANOVA results showed that there were statistically significant differences between compounds 1-4 versus placebo in all of the tested concentration (P <0.001). In conclusion, all of four alkaloids showed potent antibacterial activity against B. abortus but jatrorhizine and columbamine with free hydroxyl group on C-3 or C-2 showed more activity than palmatine and berberine without any free hydroxyl group on their structures. The antibacterial effects of columbamine (15 μg/mL) and jatrorhizine (15 μg/mL) were comparative to streptomycin (10 μg/mL) as standard drug which candidate them for more pharmacological researches to find new antibacterial agents against brucellosis.

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Antimicrobial activity of benzylisoquinoline alkaloids from Annona salzmanii D.C.

Cited by 53 publications

References 2 publications

Antimicrobial potential of 27 plants consumed by chimpanzees (Pan troglodytes verus Blumenbach) in Ivory Coast

Antimicrobial potential of 27 plants consumed by chimpanzees (Pan troglodytes verus Blumenbach) in Ivory Coast

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

Bioassay-directed isolation of quaternary benzylisoquinolines from Berberis integerrima with bactericidal activity against Brucella abortus

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