Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori

Vega, Alba Edith; Wendel, Graciela Haydée; María, A. O. M.; Pelzer, Lilian Eugenia

doi:10.1016/j.jep.2009.04.051

Cited by 31 publications

(24 citation statements)

References 26 publications

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“…This compound has also been isolated as the active constituent of A. douglasiana [32]. This species also yielded the antimicrobial sesquiterpene lactone dehydroleucodine [33].…”

Section: Sesquiterpene Lactones From Artemisia Genusmentioning

confidence: 93%

“…Vulgarone B is not the only medicinal sesquiterpene lactone from A. douglasiana. Dehydroleucodine is a sesquiterpene lactone of the guaianolide type isolated from this plant, which presented antimicrobial activity against Helicobacter pylori, the major cause of chronic gastritis and peptic ulcer, and an important factor in the pathogenesis of gastric cancer [33].…”

Section: Antimalarial and Other Anti-infective Activitiesmentioning

confidence: 99%

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The Artemisia L. Genus

Martínez

Bedoya

Ticona

et al. 2012

Studies in Natural Products Chemistry Volume 37

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“…This compound has also been isolated as the active constituent of A. douglasiana [32]. This species also yielded the antimicrobial sesquiterpene lactone dehydroleucodine [33].…”

Section: Sesquiterpene Lactones From Artemisia Genusmentioning

confidence: 93%

Section: Antimalarial and Other Anti-infective Activitiesmentioning

confidence: 99%

The Artemisia L. Genus

Martínez

Bedoya

Ticona

et al. 2012

Studies in Natural Products Chemistry Volume 37

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“…However, the full assignment of the 1 H-NMR and 13 C-NMR of either compound or the crystal structure of compound 2 have not been reported. Although, the biological activity of compound 2 has been demonstrated in various biological systems (Wendel et al, 2008; Vega et al, 2009), its activity against Gram-positive bacteria, in general, or Staphylococcus sp., in particular, has not been previously reported.…”

Section: Introductionmentioning

confidence: 99%

Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity

Ordóñez

Quave

Reynolds

et al. 2011

Journal of Ethnopharmacology

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Ethnopharmacological relevance Because of its virulence and antibiotic resistance, Staphylococcus aureus is a more formidable pathogen now than at any time since the pre-antibiotic era. In an effort to identify and develop novel antimicrobial agents with activity against this pathogen, we have examined Gynoxys verrucosa Wedd (Asteraceae), an herb used in traditional medicine in southern Ecuador for the treatment and healing of wounds. Materials and Methods The sesquiterpene lactones leucodine (1) and dehydroleucodine (2) were extracted and purified from the aerial parts of G. verrucosa, and their structure was elucidated by spectroscopic methods and single-crystal X-ray analysis. The in vitro anti-microbial activity of G. verrucosa extracts and its purified constituents was determined against six clinical isolates including S. aureus and Staphylococcus epidermidis strains with different drug-resistance profiles, using the microtiter broth method. Results Compound 1 has very low activity, while compound 2 has moderate activity with MIC50s between 49 and195 μg/mL. The extract of G. verrucosa has weak activity with MIC50s between 908 and 3290 μg/mL. Conclusions We are reporting the full assignment of the 1H-NMR and 13C-NMR of both compounds, and the crystal structure of compound 2, for the first time. Moreover, the fact that compound 2 has antimicrobial activity and compound 1 does not, demonstrates that the exocyclic conjugated methylene in the lactone ring is essential for the antimicrobial activity of these sesquiterpene lactones. However, the weak activity observed for the plants extracts, does not explain the use of G. verrucosa in traditional medicine for the treatment of wounds and skin infections.

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“…This wide range of uses led to a number of investigations into the pharmacological properties of California mugwort: In vitro studies demonstrated that California mugwort possesses antifungal activity due to the active principal vulgarone B (Meepagala et al, 2003); antibacterial (Oh et al, 1968; Vega et al, 2009) and antioxidant (Maria et al, 2000) activities due to the active principle dehydroleucodine (DhL); and antiviral activity (Garcia et al, 2003). Vulgarone B also has in vivo antimolluscidal activity (Meepagala et al, 2004; Joshi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Ethanolic extracts of California mugwort (Artemisia douglasiana Besser) are cytotoxic against normal and cancerous human cells

Somaweera

Lai

Blackeye

et al. 2013

Journal of Herbal Medicine

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California mugwort (Artemisia douglasiana Besser) is used by many tribes throughout California to treat a variety of conditions, including colds, allergies, and pain. California mugwort is also utilized as women’s medicine. Its use is on the rise outside of Native communities, often without the guidance of a traditional healer or experienced herbalist. Because it has been shown to have antiproliferative activity against plant and animal cells, we investigated whether California mugwort extracts have an effect on normal human cells as well as estrogen receptor positive (ER+) and estrogen receptor negative (ER−) human breast cancer cells. Ethanolic and aqueous extracts of A. douglasiana leaves were tested for cytotoxicity against unstimulated normal human peripheral blood mononuclear cells (hPBMC), as well as against an ER+ human breast cancer cell line (BT-474) and an ER− human breast cancer cell line (MDA-MB-231). An ethanolic leaf extract killed hPBMC, BT-474, and MDA-MB-231 cells with IC50 values of 23.6 ± 0.3, 27 ± 5, and 37 ± 4 μg/ml, respectively. An aqueous extract killed hPBMC with an IC50 value of 60 ± 10 μg/ml, but had no effect on the two cancer cell lines at concentrations up to 100 μg/ml. The results of this study indicate that the cytotoxicity of California mugwort extends to normal human cells, as well as cancerous cells. Therefore, until further is known about the safety of this medicine, caution should be taken when consuming extracts of California mugwort, whether as a tincture or as a tea.

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Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori

Cited by 31 publications

References 26 publications

The Artemisia L. Genus

The Artemisia L. Genus

Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity

Ethanolic extracts of California mugwort (Artemisia douglasiana Besser) are cytotoxic against normal and cancerous human cells

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