Antimicrobial Activity of Artemisia absinthium Against Surgical Wounds Infected by Staphylococcus aureus in a Rat Model

Moslemi, Hamidreza; Hoseinzadeh, Hesamoddin; Badouei, Mahdi Askari; Kafshdouzan, Khatereh; Fard, Ramin Mazaheri Nezhad

doi:10.1007/s12088-012-0283-x

Cited by 33 publications

(19 citation statements)

References 20 publications

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“…The number of bacteria in the test group was 3 × 10 5 cfu/wound, while in the control group 7 × 10 6 cfu/wound. The extract showed significant bactericidal effectiveness, which the authors attribute to the compounds found in the essential oil of the plant [ 86 ].…”

Section: Biological Activities Confirmed By Scientific Researchmentioning

confidence: 99%

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Szopa

Pajor

Klin

et al. 2020

Plants

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Artemisia absinthium—wormwood (Asteraceae)—is a very important species in the history of medicine, formerly described in medieval Europe as “the most important master against all exhaustions”. It is a species known as a medicinal plant in Europe and also in West Asia and North America. The raw material obtained from this species is Absinthii herba and Artemisiae absinthii aetheroleum. The main substances responsible for the biological activity of the herb are: the essential oil, bitter sesquiterpenoid lactones, flavonoids, other bitterness-imparting compounds, azulenes, phenolic acids, tannins and lignans. In the official European medicine, the species is used in both allopathy and homeopathy. In the traditional Asian and European medicine, it has been used as an effective agent in gastrointestinal ailments and also in the treatment of helminthiasis, anaemia, insomnia, bladder diseases, difficult-to-heal wounds, and fever. Today, numerous other directions of biological activity of the components of this species have been demonstrated and confirmed by scientific research, such as antiprotozoal, antibacterial, antifungal, anti-ulcer, hepatoprotective, anti-inflammatory, immunomodulatory, cytotoxic, analgesic, neuroprotective, anti-depressant, procognitive, neurotrophic, and cell membrane stabilizing and antioxidant activities. A. absinthium is also making a successful career as a cosmetic plant. In addition, the importance of this species as a spice plant and valuable additive in the alcohol industry (famous absinthe and vermouth-type wines) has not decreased. The species has also become an object of biotechnological research.

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Section: Biological Activities Confirmed By Scientific Researchmentioning

confidence: 99%

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Szopa

Pajor

Klin

et al. 2020

Plants

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“…Sensitive to the Tinctura Absinthii were mainly Gram-positive oral bacteria and yeast while it did not affect the growth of Gram-negative microorganisms and probiotic strains B. subtilis UKM В-5007, B. licheniformis UKM В-5514. Moslemi et al (2012) showed that topical application of A. absinthium extract on the infected wound sites in rat models produced significant antibacterial activity against S. aureus.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of phytoextracts on opportunistic oral bacteria, yeast and bacteria from probiotics

Vorobets

Kryvtsova

Rivis

et al. 2018

Regul. Mech. Biosyst.

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Developed experimental assays enable us to compare the antimicrobial activity of herbal medicinal drugs on Lactobacillus and Bacillus strains probiotics, which have been claimed to possess the ability of suppressing the growth of various oral pathogens. In the treatment of periodontal disease it is advisable to use a comprehensive approach which would include the application of herbal remedies and probiotics. The combination of such effects may be a new approach in dentistry due to their complementary antimicrobial activity. In this study, we researched antimicrobial effects of herbal medicinal drugs (tinctures of some medical plants, solutions Rotocanum and Chlorophyllipt) against collection strains and clinical strains isolated from the oral cavity of patients with periodontitis, and probiotic strains Bacillus subtilis UKM В-5007 and Bacillus licheniformis UKM В-5514 that are part of the active base of probiotic Biosporin (Ukraine), Bacillus clausii from the probiotic Normaflore (Hungary), as well as the strains Lactobacillus spp. – from probiotic Lactobacterinum (Biopharma, Ukraine). For investigation, the standard agar dilution method was used in modification with glass cylinders. The results of the research showed that among the studied herbal medicinal remedies, tinctures of Eucalypthus viminalis, Mentha piperita and Chlorophyllipt had the strongest antimicrobial activity. Probiotic strains are also sensitive to herbal tinctures (except the tinctura of wormwood), which indicate the possibility of only consecutive usage (with an interval of time) of herbal remedies and probiotics in combination therapy in the treatment of periodontal diseases.

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“…Plant products are potential agents for wound healing and are largely preferred because of their widespread availability, non-toxicity, lack of unwanted side effects and their effectiveness as crude preparations. A therapeutic agent selected for wound healing must improve at least one phase of healing process without producing any side effects [21]. Many plants are used as topical wound healers in Persian traditional medicine.…”

Section: Discussionmentioning

confidence: 99%

Wound healing potential of Capparis spinosa against cutaneous wounds infected by Escherichia coli in a rat model

et al. 2015

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S u m m a r yWound infection has become a major medical problem in recent years. This study was conducted to evaluate the healing activity of Capparis spinosa against surgical wounds infected by Escherichia coli. Twenty male rats were divided into two groups. Excisions were created surgically on the animals' skin and then infected with E . coli. Group 1 was treated with C . spinosa while Group 2 was untreated. Wound biopsy specimens were collected on days 5, 10 and 16 and analyzed. Results showed that the hydroxyproline content in treatment group was significantly higher in various post wounding days. Protein content increased gradually in ten days. Results of histopathological studies showed moderate to intense granulation tissue formation in treated group on day 10. The histopathological studies showed, that the new epidermis in treated group was thicker than in control group on day 16 post wounding. The present study has demonstrated that ethanol extract of C . spinosa includes properties that accelerate wound healing activities. INTRODUCTIONWound is defined simply as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissue. Wound healing is a programmed biological process that restores tissue continuity after injury and is a combination of physical, chemical and cellular events that restore the wounded tissue or replace it with collagen. Wound healing can be divided into three stages, including inflammation, proliferation and remodeling and maturation phases which involve the interaction of various cells, cytokines and growth factors [1]. The normal healing response begins immediately after the injury. When blood spills into the site of injury, the blood platelets contact with collagen and other elements of the extracellular matrix. This triggers the release of clotting factors as well as essential growth factors and cytokines such as platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-β). The inflammatory phase begins after the migration of neutrophils to the wound site to clean the tissue. Then, fibroblasts migrate into the tissue to begin the proliferative phase and deposit new extracellular matrix. This new collagen matrix becomes cross linked and organized [2].Due to poor hygienic conditions in undeveloped and developing countries, wound infection has become a common disease in recent years [3]. Several reports associating the enterobacterium Escherichia coli with skin and soft tissue infections have been published: E . coli was found to be the causative agent of neonatal omphalitis [4], cellulitis localized to lower or upper limbs [5], necrotizing fasciitis [6,7], surgical site infections [8], infections after burn injuries [9]. A public tendency towards the use of herbal wound healers is increasing, possibly due to lower side effects and prices of herbals, compared to chemical drugs.Capparis spinosa (caper) (family Capparidaceae) is one of the most common aromati...

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Antimicrobial Activity of Artemisia absinthium Against Surgical Wounds Infected by Staphylococcus aureus in a Rat Model

Cited by 33 publications

References 20 publications

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Antimicrobial activity of phytoextracts on opportunistic oral bacteria, yeast and bacteria from probiotics

Wound healing potential of Capparis spinosa against cutaneous wounds infected by Escherichia coli in a rat model

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