Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla

Freile, M.L.; Giannini, Fernando; Pucci, Graciela; Sturniolo, A.; Rodero, L; Pucci, O.; Balzareti, V.; Enriz, Ricardo D.

doi:10.1016/s0367-326x(03)00156-4

Cited by 112 publications

(76 citation statements)

References 10 publications

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“…7) It is widely used in traditional Chinese medicine as an antimicrobial and anti-tumor agent. 6,17) The ability of cytotoxicity to act as topoisomerase I or II poison was reported to be related to the anti-tumor activity, in which the DNA binding process was of vital importance. However, cytotoxicity was exhibited at the concentration of over 200 mM in 3T3-L1 adipocytes and Min6 cells in our study (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma

Choi

Park

et al. 2005

Biological & Pharmaceutical Bulletin

170

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Type 2 diabetes is a heterogeneous metabolic disorder characterized by the impairment of insulin secretion from pancreatic b-cells and insulin resistance in peripheral tissues such as the liver, skeletal muscle and adipose tissue.1) In most cases, insulin resistance mostly precedes the impairment of insulin secretion in humans. For example, obesity induces hepatic, skeletal muscle and adipocyte insulin resistance, and hypersecretion of insulin maintains normoglycemia by compensating for insulin resistance. As long as insulin secretion compensates for peripheral insulin resistance, diabetes is not developed and exacerbated. Thus, herbs or drugs for type 2 diabetes mellitus should have an insulin sensitizing action to relieve insulin resistance and an insulinotropic action to improve glucose-stimulated insulin secretion and pancreatic b-cell survival.Extracts from Coptidis Rhizoma (CR) and Cortex Phellodendri, a Southeast Asian herb, have been used to treat diabetes mellitus for more than one thousand years in the history of Chinese medicinal remedies. , one of the main constituents of CR and Cortex Phellodendri, is a type of isoquinoline alkaloid, suggesting that it is a candidate of the principal anti-diabetic constituents of CR. According to reports, 2-4) berberine acts as an a-adrenoceptor antagonist. In addition, some aadrenoceptor antagonists, such as phentolamine, stimulate insulin release by inhibiting pancreatic b-cell ATP-sensitive potassium channels. 5,6) Berberine is a candidate for insulin secretagogues, but it's effect was not sufficient to recommend CR or berberine to treat type 2 diabetes. Post-prandial hyperglycemia is a prominent early defect in type 2 diabetes, predominantly due to loss of acute phase insulin secretion after eating. 7,8) Thus, insulin secretagogues have long been used as a diabetic drug to reduce post-prandial hyperglycemia to normal levels. Insulin secretagogues such as sulfonylurea make normoglycemia in the early stage of diabetes. However, most of them stimulate insulin secretion with and without glucose challenge by closing ATP-sensitive potassium channels in b-cells. 7,8) As a result, they increase insulin secretion without glucose loading, resulting in exhausting and damaging b-cells and frequent hypoglycemia. Eventually, they exacerbate the symptoms of diabetes. The ideal agent to treat post-prandial hyperglycemia should restore the acute-phase insulin secretion without hypoglycemia and enhance pancreatic b-cell survival. Thus, an insulinotropic agent is a better anti-diabetic agent than a simple insulin secretagogue. Insulinotropic agents, such as glucagon like peptide-1 receptor agonist (exendin-4), improve glucose-stimulated acute insulin secretion with the expansion of b-cell mass through improving insulin like growth factors (IGF)-1 and/or insulin. [9][10][11] In the present study, the fractions of CR were investigated for their effects as an insulin sensitizer through insulin-mediated glucose uptake in 3T3-L1 adipocytes and as an insulinotropic agent in Min6 cells. ...

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Section: Discussionmentioning

confidence: 99%

Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma

Choi

Park

et al. 2005

Biological & Pharmaceutical Bulletin

170

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“…Berberine displayed a significant antibacterial and antifungal activity against Staphylococcus aureus and different Candida spp., (MIC = 64 μg/mL for Candida albicans) (Freile et al, 2003). Other in vitro studies have shown that berberine is effective against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis (Kaneda et al, 1991), Helicobacter pylori (MIC 50 = 12.5 μg/mL) (Mahady et al, 2003) and Leishmania donovani (Ghosh et al, 1985).…”

Section: Antimicrobial Effectsmentioning

confidence: 97%

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Imanshahidi

Hosseinzadeh

2008

Phytotherapy Research

534

321

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Barberry (Berberis vulgaris L. family Berberidaceae) is well known in Iran and various parts of this plant including its root, bark, leaf and fruit have been used as folk medicine. The two decades of research has demonstrated different pharmacological and therapeutic effects of B. vulgaris and its isoquinoline alkaloids (particularly berberine). Studies carried out on the chemical composition of the plant show that the most important constituents of this plant are isoquinoline alkaloids such as berberine, berbamine and palmatine. Berberine represents one of the most studied among the naturally occurring protoberberine alkaloids. In addition to B. vulgaris (barberry), berberine is present in many other plants and is used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and the most active ingredient of B. vulgaris (berberine).

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“…Berberine is an isoquinoline alkaloid widely used in traditional eastern homeotherapy, particularly in treating gastrointestinal infections [20][21][22]. It has been extensively reviewed in the literature as interesting natural compound of wide potential medicinal applications [23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine

Almasri

Mohammad

Taha

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

126

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Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla

Cited by 112 publications

References 10 publications

Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma

Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine

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