Pharmacological and therapeutic effects of <i>Berberis vulgaris</i> and its active constituent, berberine

Imanshahidi, Mohsen; Hosseinzadeh, Hossein

doi:10.1002/ptr.2399

Cited by 534 publications

(343 citation statements)

References 103 publications

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“…Co-administration of BV extract significantly reduced blood and renal intracellular lead levels in a dosedependent manner. Previous studies reported that B. vulgaris contains polyphenolics [8,26] , which are known for their metal-chelating ability [27][28] . This might be one of the mechanisms by which B. vulgaris decreases lead content in blood and kidney, and therefore potentiates its body clearance.…”

Section: Resultsmentioning

confidence: 99%

“…The species is commonly known as āġrys in Moroccan pharmacopoeia, and used to cure renal disorders and other diseases [7] . Moreover, it is the most widely used drug in homeopathic system of medicine for kidney pain as well as removal of kidney stones [8] . Many studies report protective effects of B. vulgaris and some of its bioactive molecules, especially berberine, which is the most important alkaloid claimed to be responsible for beneficial effects of B. vulgaris.…”

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confidence: 99%

“…Many studies report protective effects of B. vulgaris and some of its bioactive molecules, especially berberine, which is the most important alkaloid claimed to be responsible for beneficial effects of B. vulgaris. Moreover, many studies report antioxidant effects of B. vulgaris, and several polyphenols with antioxidant activities have been isolated from root, bark, leaf and fruit [8][9] . To our knowledge, this is the first study to evaluate B. vulgaris effects against leadinduced nephrotoxicity in mice.…”

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confidence: 99%

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Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Laamech¹,

El-Hilaly²,

Fetoui³

et al. 2016

pharmaceutical-sciences

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Laamech, et al.: Berberis vulgaris Effect on Lead Nephrotoxicity in MiceThis study aimed to investigate the potential effects of Berberis vulgaris L. against lead acetate-induced nephrotoxicity in Swiss albino mice. Mice were exposed chronically to lead acetate, at a dose of 5 mg/kg, alone or in conjunction with B. vulgaris extract (25, 50, 100 and 150 mg/kg). Lead acetate administration increased lead burden in blood and kidneys, altered renal biomarkers (serum creatinine, urea and uric acid), increased malondialdehyde and protein carbonyls levels, and decreased reduced glutathione, glutathione peroxidase, catalase, and superoxide dismutase. Histological studies showed glomerular degeneration and hypercellularity. However, B. vulgaris extract co-treatment significantly and dose-dependently restored the renal parameters, antioxidant enzymes, and histopathological changes near to the normal status, mainly via its antioxidant properties and/or by preventing lead bioaccumulation. Therefore, B. vulgaris extract showed nephroprotective effects against lead-induced nephrotoxicity mainly through its antioxidant and metal chelating properties.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Laamech¹,

El-Hilaly²,

Fetoui³

et al. 2016

pharmaceutical-sciences

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“…Berberine is an isoquinoline alkaloid extracted from several plants, including Hydrastis canadensis (goldenseal), Berberis aquifolium (Oregon grape), and Berberis vulgaris (barberry). Berberine has strong antimicrobial activities, and has been used to treat bacterial diarrhea, intestinal parasitic infections, and ocular trachoma infections for several decades (Imanshahidi and Hosseinzadeh, 2008;Sun et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose-and time-dependent manner and was observed to induce a series of biochemical events, including the loss of mitochondrial membrane potential, release of cytochrome-c to cytosol, induction of proteins of the Bcl-2 family and caspases, and the cleavage of poly(ADP)-ribose polymerase. This suggested its ability to induce apoptosis. The results of a wound healing test revealed that berberine inhibited the migration of A431 cells. Ezrin was transfected into A431 cells by RNA interference. The level of expression of Ezrin in the transfected A431 cells was observed to decrease with berberine treatment, which suggested that berberine might inhibit the invasion of A431 cells through Ezrin. The results of this study 10553-10568 (2015) demonstrated that berberine could potentially inhibit proliferation, induce apoptosis, and inhibit the invasion of A431 cells.

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“…B. vulgaris and B. stata are the two most studied species of Berberis (15)(16)(17)(18). Alkaloids constitute the major class of compounds reported to exist in Berberis species and represent a very wide range of secondary metabolites with important biological activities (19,20).…”

Section: Introductionmentioning

confidence: 99%

Berberis libanotica extract targets NF-κB/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis

Diab

Fidanzi

Léger

et al. 2015

International Journal of Oncology

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Abstract. The aim of this study was to describe and understand the relationship between cyclooxygenase-2 (COX-2) expression and apoptosis rate in erythroleukemia cells after apoptosis induction by Berberis libanotica (Bl) extract. To achieve this goal we used erythroleukemia cell lines expressing COX-2 (HEL cell line) or not (K562 cell line). Moreover, we made use of COX-2 cDNA to overexpress COX-2 in K562 cells. In light of the reported chemopreventive and chemosensitive effects of natural products on various tumor cells and animal models, we postulated that our Bl extract may mediate their effects through apoptosis induction with suppression of cell survival pathways. Our study is the first report on the specific examination of intrinsic apoptosis and Akt/NF-κB/COX-2 pathways in human erythroleukemia cells upon Bl extract exposure. Even if Bl extract induced apoptosis of three human erythroleukemia cell lines, a dominant effect of Bl extract treatment on K562 cells was observed resulting in activation of the late markers of apoptosis with caspase-3 activation, PARP cleavage and DNA fragmentation. Whereas, we showed that Bl extract reduced significantly expression of COX-2 by a dose-dependent manner in HEL and K562 (COX-2 + ) cells. Furthermore, in regard to our results, it is clear that the simultaneous inhibition of Akt and NF-κB signalling can significantly contribute to the anticancer effects of Bl extract in human erythroleukemia cells. We observed that the Bl extract is clearly more active than the berberine alone on the induction of DNA fragmentation in human erythroleukemia cells.

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Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Cited by 534 publications

References 103 publications

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

Berberis libanotica extract targets NF-κB/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis

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