Antimicrobial activity induction by PSK subfractions: Dependence on molecular weight

Harada, Hiroshi; Sakagami, Hiroshi; Konno, Kunio; Sato, Tsuneo; Osawa, Naoya; Fujimaki, M; Komatsu, N

doi:10.1007/bf01643499

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…Quel, has been recognized for its host-mediated antitumor activity.1) However, there are few reports of PSK effects on experimental infections in mice. 2,3) To better understand the induction of antibacterial activity, we investigated the effects of PSK administered by various routes on Escherichia toll infection in mice, and the kinetics of the accumulation and activation of the peritoneal exudate cell populations after PSK administration. Table 1 shows that significant antibacterial activity of PSK was induced when the mice were administered 40 mg/kg PSK by either an intraperitoneal, subcutaneous, or intramuscular route (Exp.…”

Section: Introductionmentioning

confidence: 99%

Effects of Pretreatment with PSK, a Protein-Bound Polysaccharide, on Escherichia Coli Infection in Mice

Sakagami

Konno

Kurakata

et al. 1990

The Showa University Journal of Medical Sciences

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Only 17% of mice inoculated with lethal doses of Escherichia coli survived for 5 days after the challenge. Significant antibacterial activity of PSK, a protein-bound polysaccharide, was induced when the mice were pretreated with 40 mg/kg of PSK by an intraperitoneal, subcutaneous or intramuscular route, but not by an intravenous route, 48 hr before the E. coli inoculation. Repeated oral administration of PSK for 2 weeks (20 mg/kg, 3 times per week) before E. coli inoculation was also effective. Intraperitoneal administration of PSK was most potent, inducing significant polymorphonuclear cell accumulation and generation of luminol-dependent chemiluminescence by peritoneal exudate cells, with a peak 24 hr after administration of the PSK.

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Section: Introductionmentioning

confidence: 99%