Antimicrobial Activity and Mechanism of Polyvinyl Chloride Composite Containing Inorganic Bacteriocide

Abstract

Bacterial infection is one of the most common and universal cause of disease spreading associated with medical and surgical environment. Antimicrobial function of plasticized polyvinyl chloride (PVC) will be useful for making hygienic environments. Here, we synthesized the PVC composite by the addition of inorganic bacteriocide containing silver, zinc and zeolite. And we investigated the growth inhibition rate for Staphylococcus aureus and Klebsiella pneumoniae which were analyzed in the presence of PVC composite with different doses of inorganic bacteriocide (1~15 wt%). Bacterial proliferation was significantly inhibited by 3 wt% of inorganic bacteriocide containing PVC composite. And we found the inhibition of bacterial biofilm formation by 5 wt% of inorganic bacteriocide containing PVC composite by the observation of scanning electron microscopy (SEM). Our data suggested that the antimicrobial effect of inorganic bacteriocide was caused by disturbing the bacterial biofilm formation.

A new antimicrobial PVC-based polymeric material incorporating bisacylthiourea complexes

“…Silver/PVC nanocomposites proved to be an efficient antibacterial agent [ 21 ] using either ionic or metallic silver [ 22 ]. Evaluation of PVC compounds containing different doses of silver, zinc and zeolite clearly pointed out the formation of bacterial biofilms as the main factor of the antimicrobial effect of the additive [ 23 ]. Furthermore, an efficient antimicrobial powder based on guanidine, symmetrical porphyrin PVC plastics [ 24 , 25 ], and maleimido phenyl thiourea composite-based PVC powder [ 26 ] were reported.…”