A new antimicrobial PVC-based polymeric material incorporating bisacylthiourea complexes

Abstract

A new antimicrobial material incorporating Cu(I) and Cd(II) complexes of bisacylthiourea derivatives in a PVC film was successfully synthesized and characterized by IR, UV, NMR, SEM, and thermal analyses. The results revealed that on coordination, the electronic structure change of the ligand affects practically all their spectral vibrational pattern; however, within the complex pattern, some vibrations indicated that the thiourea derivative behaves as a neutral ligand, which coordinates the metal ion through the sulfur atom of the thiocarbonyl group. The greater affinity of the S atom for Cu+ 1 played a role in Cu(II)→Cu(I) reduction, and the intramolecular hydrogen bonds of the type of (NH···Cl) further stabilized the obtained Cu(I) complex in dioxane. The antimicrobial activity shows that all investigated compounds exhibit excellent activity compared to standard antibiotics. The antibacterial power of the PVC/Cd composite is significantly superior against the most resistant species to both disinfectants and antibiotics compared to its PVC/Cu analogue; nevertheless, the latter exhibited activity equal to an average halo diameter of 29 ± 0.33 mm against pathogenic E. coli ATCC 25,922, indicating excellent G (-) activity. Interestingly, the PVC/Cd composite exhibited excellent activity against pathogenic C. albicans RCMB 005003 (1) ATCC 10,231, while its PVC/Cu analogue was inactive. These materials may be used to reduce infection in wounds either as a composite film or coated barrier dressings, and in addition, the results should open a new direction in antimicrobial surface engineering within the biomedical field. Further challenges are the development of reusable and broad-range antimicrobial polymers..

A promising perspective through potential antimicrobial, anti‐cancer, and antiviral activity against SARS‐CoV‐2 of silver(I) complexes: Synthesis, characterization, density functional theory calculations, and in‐silico molecular docking studies

“…51,52 Chelation reduces the polarity of the silver ion and rises the delocalization of π-electrons over the chelate ring and permits permeation of the complexes via the lipid layer of the cell membrane and consequently blocks the metal-binding sites on the enzymes of the microorganism, this improves the rate of uptake/entrance and therefore increases the antimicrobial activity of the silver complexes. 53 However, the differences in the detected susceptibilities between the microorganisms and the investigated compounds would owe to the variances in genetic constitutions that occur between various microbial strains, 54 developed resistance formed by many mutations in chromosomal genes, acquisition of resistance genes by horizontal transfer enabled by bacteriophages, transposons, and plasmids, 55 additionally, by cell permeability, whereas lipid membrane that surrounds the cell helps the passageway of lipid-soluble materials only.…”

Antimicrobial Efficacy of a Vegetable Oil Plasticizer in PVC Matrices

“…Ongoing research endeavors focus on the modification of PVC to imbue it with antimicrobial properties. Such enhancements hold promise in mitigating the risk of infections and cross-contamination across various industrial processes [ 14 , 15 ].…”