Abstract:Bitter melon, bitter cucumber or bitter gourd are some of the names given to M. charantia. It belongs to the Cucurbitaceae family. 44 M. charantia is a vegetable with many culinary uses, especially in Asia and Africa, and is commonly cultivated in Africa, India, Malaysia, China and South America. 44,45 M.ABSTRACT Momordica charantia L. (bitter melon) is a plant belonging to the Cucurbitaceae family and is widely distributed in tropical and subtropical areas around the world, mainly in Asia, India, China and Br… Show more
“…M. charantia contains compounds such as momorcharin, momordenol, momordicillin, momordicinin I, II and III, momordine, momordolol, charantin, charine, cryptoxanthin, cucurbitans, cycloartenol, diosgenin, eleostearic acid, erythrodiol, galacturonic acids, gentisic acid, goyasaponin, and multiflorenol [ 15 - 18 ]; which are responsible for its various biological and pharmacological effects such as antidiabetic [ 19 ], antiulcer [ 20 ], antimicrobial [ 21 ], and antioxidant [ 22 ]. In addition, MAP30 protein that shows anti-HIV activity has also been identified in M. charantia [ 23 ].…”
Background and Aim: Momordica charantia is mainly characterized by its antimicrobial and antioxidant properties. The current study aimed to evaluate the healing activity of gel and cream formulations based on M. charantia on induced wounds in mice.
Materials and Methods: Acetonic extract of M. charantia was prepared and incorporated into gel and cream formulations. Mus musculus Balb/c (n=30) with induced injury were distributed into five groups: Group I (control – day 7), Group II (control – day 14), Group III (1% gel – day 7), and Group IV (1% gel – day 14) to which 1% M. charantia gel was dermally applied daily for 7 and 14 days, respectively, Group V (1% cream – day 7) and Group VI (1% cream – day 14) to which of M. charantia 1% cream were dermally applied daily for 7 and 14 days, respectively. Time of wound closure was determined during the experimentation; rats were euthanized with sodium pentobarbital 60 mg/kg/pc v.ip. for obtaining skin samples for histopathological analysis.
Results: Groups IV and VI showed a higher percentage of wound closure on day 14, and in histopathological analysis, effect was greater in Group VI with the presence of fibroblasts and abundant collagen and elastic fibers.
Conclusion: M. charantia gel and cream showed wound healing activity on induced wounded mice; the most effective treatment was M. charantia 1% cream formulation.
“…M. charantia contains compounds such as momorcharin, momordenol, momordicillin, momordicinin I, II and III, momordine, momordolol, charantin, charine, cryptoxanthin, cucurbitans, cycloartenol, diosgenin, eleostearic acid, erythrodiol, galacturonic acids, gentisic acid, goyasaponin, and multiflorenol [ 15 - 18 ]; which are responsible for its various biological and pharmacological effects such as antidiabetic [ 19 ], antiulcer [ 20 ], antimicrobial [ 21 ], and antioxidant [ 22 ]. In addition, MAP30 protein that shows anti-HIV activity has also been identified in M. charantia [ 23 ].…”
Background and Aim: Momordica charantia is mainly characterized by its antimicrobial and antioxidant properties. The current study aimed to evaluate the healing activity of gel and cream formulations based on M. charantia on induced wounds in mice.
Materials and Methods: Acetonic extract of M. charantia was prepared and incorporated into gel and cream formulations. Mus musculus Balb/c (n=30) with induced injury were distributed into five groups: Group I (control – day 7), Group II (control – day 14), Group III (1% gel – day 7), and Group IV (1% gel – day 14) to which 1% M. charantia gel was dermally applied daily for 7 and 14 days, respectively, Group V (1% cream – day 7) and Group VI (1% cream – day 14) to which of M. charantia 1% cream were dermally applied daily for 7 and 14 days, respectively. Time of wound closure was determined during the experimentation; rats were euthanized with sodium pentobarbital 60 mg/kg/pc v.ip. for obtaining skin samples for histopathological analysis.
Results: Groups IV and VI showed a higher percentage of wound closure on day 14, and in histopathological analysis, effect was greater in Group VI with the presence of fibroblasts and abundant collagen and elastic fibers.
Conclusion: M. charantia gel and cream showed wound healing activity on induced wounded mice; the most effective treatment was M. charantia 1% cream formulation.
“…Moreover, compounds 1 – 4 were examined for antiproliferative activity against MCF-7 (human breast adenocarcinoma), Doay (human human medulloblastoma), HEp-2 (human laryngeal carcinoma), and WiDr (human colon adenocarcinoma) tumor cell lines in vitro, while these four isolates show no anti-cancer effect (data not shown) in consistence with MC used as TCM, which is well established to do with bitter flavor (cold property), nontoxicity, and relief of fatigue ( Chen et al, 2015 ). Concerning antimicrobial activities, various fractions of MC extracts showed no harm to microbials ( Khan and Omoloso, 1998 , Villarreal-La Torre et al, 2020 ), indirectly suggesting that cucurbitacins as an adjuvant in TCM are nonpoisonous and could be metabolized by microorganisms, so that compounds 1 – 4 are likely the metabolites of microorganisms. Fig.…”
“…Moreover, an immense variety of diseases such as hemorrhoids, fever, sore chest, paralysis, herpes, lung inflammation, asthma, malaria, leprosy, for blood cures, and headache are also treated with the Cucurbitaceae species [ 22 , 23 , 24 ]. A variety of investigations have demonstrated the biological properties of the members of the Cucurbitaceae family, such as antibacterial, antioxidant, anti-inflammatory, anticancer, antidiabetic, anti-HIV, anti-pyretic, and antihelminthic [ 13 , 25 ]. However, the traditional use of Cucurbitaceae in the treatment of chronic diseases such as DM, cancer, and arthritis is also documented [ 26 , 27 , 28 ].…”
Section: Generalities Of the Cucurbitaceae Familymentioning
In Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico. The reviewed species (Cucurbita ficifolia, C. maxima, C. moschata, C. pepo, Ibervillea sonorae, Sechium edule, Citrullus lanatus, Cucumis melo, and C. sativus) revealed that the antidiabetic effects exerted are effective in a number of mechanisms involved in the complex pathogenesis of DM: hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, protective effects on diverse organs and cells, as well as in the control of dyslipidemias; furthermore, the select species of the Cucurbitaceae family could also be essential components of diets for the control of DM in patients with the disease. Thus, the Cucurbitaceae species selected in the present work represent a source of antidiabetic agents that perhaps establish the bases for novel clinical treatments.
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