Four cucurbitane glycosides taimordisins A–D with novel furopyranone skeletons isolated from the fruits of Momordica charantia

Liaw, Chia‐Ching; Lo, I‐Wen; Lin, Yu-Chi; Huang, Hung‐Tse; Zhang, Lijie; Hsiao, Pin-Chun; Li, Tsung‐Lin; Kuo, Yao‐Haur

doi:10.1016/j.fochx.2022.100286

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Furthermore, triterpene glycosides called taimordisins A (185) and B (186) were isolated from the fresh fruits of Taiwanese Momordica charantia [174]. Although these compounds demonstrate favorable anti-inflammatory activity, they do not exhibit any anti-cancer properties and have been determined to be safe for use. )…”

Section: Furanosteroids Derived From Plant Speciesmentioning

confidence: 99%

Fascinating Furanosteroids and Their Pharmacological Profile

Dembitsky

2023

Molecules

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This review article delves into the realm of furanosteroids and related isoprenoid lipids derived from diverse terrestrial and marine sources, exploring their wide array of biological activities and potential pharmacological applications. Fungi, fungal endophytes, plants, and various marine organisms, including sponges, corals, molluscs, and other invertebrates, have proven to be abundant reservoirs of these compounds. The biological activities exhibited by furanosteroids and related lipids encompass anticancer, cytotoxic effects against various cancer cell lines, antiviral, and antifungal effects. Notably, the discovery of exceptional compounds such as nakiterpiosin, malabaricol, dysideasterols, and cortistatins has revealed their potent anti-tuberculosis, antibacterial, and anti-hepatitis C attributes. These compounds also exhibit activity in inhibiting protein kinase C, phospholipase A2, and eliciting cytotoxicity against cancer cells. This comprehensive study emphasizes the significance of furanosteroids and related lipids as valuable natural products with promising therapeutic potential. The remarkable biodiversity found in both terrestrial and marine ecosystems offers an extensive resource for unearthing novel biologically active compounds, paving the way for future drug development and advancements in biomedical research. This review presents a compilation of data obtained from various studies conducted by different authors who employed the PASS software 9.1 to evaluate the biological activity of natural furanosteroids and compounds closely related to them. The utilization of the PASS software in this context offers valuable advantages, such as screening large chemical libraries, identifying compounds for subsequent experimental investigations, and gaining insights into potential biological activities based on their structural features. Nevertheless, it is crucial to emphasize that experimental validation remains indispensable for confirming the predicted activities.

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Section: Furanosteroids Derived From Plant Speciesmentioning

confidence: 99%