Antimetabolite-metabolite cancer chemotherapy using continuous intra-arterial methotrexate with intermittent intramuscular citrovorum factor.<i>Method of therapy</i>

Duff, John K.; Sullivan, Robert D.; Miller, Edward; Ulm, Aaron Hardy; Clarkson, Bayard D.; Clifford, Peter

doi:10.1002/1097-0142(199007/08)14:4<744::aid-cncr2820140411>3.0.co;2-s

Cited by 56 publications

(7 citation statements)

References 2 publications

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“…It is essential to check the position of the catheter tip, which cannot easily be palpated within the vessel and may even inadvertently enter the internal carotid. Arteriography, used in the early cases, has been replaced by the gentle instillation of a few millilitres of 5% fluorescein, viewing the area supplied in ultra-violet light (Duff et al, 1961). This method has the advantages of speed and simplicity, and, moreover, avoids possible artifacts produced by the necessarily forcible injection of contrast medium.…”

Section: Methodsmentioning

confidence: 99%

Recurrent Cancer of Head and Neck

Westbury¹,

Newton²,

Humble³

et al. 1962

BMJ

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Section: Methodsmentioning

confidence: 99%

Recurrent Cancer of Head and Neck

Westbury¹,

Newton²,

Humble³

et al. 1962

BMJ

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“…On the other hand, Duff et a1. 8 and Sullivan et all7 stated that there was a remarkable tumor response in the patients with inoperable cancers treated with the intraarterial infusion of methotrexate. Clarkson et aL5 stated that when 16 cases with metastases or primary cancer in the liver were treated with the prolonged continuous infusion of methotrexate or one of the fluorinated pyrimidines into the hepatic artery, 9 cases showed some evidence of beneficial effect, with a definite reduction in the liver size and the degree of pain and subsistence of any fever present.…”

Section: Discussionmentioning

confidence: 99%

Studies on preoperative cancer chemotherapy.Methods of preoperative intra-arterial infusion by the use of methotrexate or vinblastine

Fujimoto

Watanabe

Enomoto

et al. 1969

Cancer

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For the purpose of performing combined therapy with surgery and preoperative intra‐arterial infusion of methotrexate or vinblastine, polyethylene catheters were inserted into the right gastroepiploic artery of 18 patients with gastric cancer, through a small midline incision in the epigastrium. The best positioning of the catheter was decided by infusion of Evans blue. The dose schedules were approximately as follows: 1. methotrexate group: 33 mg of methotrexate were continuously infused 3 times within 36 hours before gastrectomy and 15 mg of leucovorin intramuscularly at one hour after each infusion; 2. vinblastine group: 6 mg of vinblastine were administered twice within 24 hours before gastrectomy and its 3 antidotes intravenously within one hour after the start of each infusion. Pathologic examination after surgery showed prevention of DNA biosynthesis and irreversible changes of chromosomes in cancer cells. The preoperative infusion of the drugs was accompanied by little complication in the postoperative course after gastrectomy.

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“…Ramsden and Duff5' were the first to cannulate the superficial temporal artery and advance a catheter retrograde for perfusion of the ECA. Duff et al 49 later reported a technique of introducing a catheter into the common or ECA through a purse string suture in the artery. Oettgen, Duff, and Clifford 53 also described the purse string technique.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Intraarterial chemotherapy for head and neck cancer, part 1: Theoretical considerations and drug delivery systems

Baker

Wheeler

1983

Head Neck

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The principal objective of regional chemotherapy is tumor cell kill. The rationale for regional delivery is based on the steep dose/response curve exhibited by most antineoplastic agents. Intraarterial (IA) chemotherapy has the potential advantage of increased drug concentration at the tumor site, decreased systemic drug levels, and continuous tumor cell exposure to an antineoplastic agent. Despite these advantages, the use of IA chemotherapy has not been universally accepted. This is in part due to the difficulties associated with establishing and maintaining arterial access. Considerable improvement in the techniques and efficacy of regional therapy for head and neck cancer will be necessary before there is widespread clinical acceptance. These improvements must be based on anatomic and pharmacologic factors that ensure success of regional therapy. In addition, the development of safe, reliable delivery systems will be necessary. Part 1 of this two-part article will review these factors and discuss delivery systems.

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Antimetabolite-metabolite cancer chemotherapy using continuous intra-arterial methotrexate with intermittent intramuscular citrovorum factor.Method of therapy

Cited by 56 publications

References 2 publications

Recurrent Cancer of Head and Neck

Recurrent Cancer of Head and Neck

Studies on preoperative cancer chemotherapy.Methods of preoperative intra-arterial infusion by the use of methotrexate or vinblastine

Intraarterial chemotherapy for head and neck cancer, part 1: Theoretical considerations and drug delivery systems

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