Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species of<i>Ocimum</i>in C<sub>57</sub>BL mice

Monga, Jitender; Sharma, Manu; Tailor, Naveen Kumar; Ganesh, N.

doi:10.3109/13880209.2010.521513

Cited by 46 publications

(26 citation statements)

References 32 publications

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“…Aqueous leaf extract also showed antidiarrheal activity such as delay in onset of defecation, reduced intestinal fluid accumulation and reduced cumulative faecal weight in rats [31]. The hydro-methanolic leaf extract significantly lowered the tumour volume and increased survival rate of mice showing antimelanoma potential and partial protection to bone marrow [32]. In Kenya, the infusion of leaves is taken to cure measles and also mixed with Lippia ukamensis to treat flue and stomachache.…”

Section: Economic Potentialmentioning

confidence: 97%

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

Misra

Das

2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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Ocimum kilimandscharicum Guerke (Lamiaceae), alien to the Indian flora, was discovered in the natural habitat from two locations of different agro-ecological zones of Odisha. After critical review of published literature on distribution, it was earlier known only from Uttarakhand. However, its natural occurrence in Odisha was found to be a new record for peninsular India. A detailed diagnostic description, photographs, ecology and potentiality of the species was provided for easy identification and further economic utilization.

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Section: Economic Potentialmentioning

confidence: 97%

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

Misra

Das

2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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“…These findings demonstrate that Ocimum species have antimelanoma and radioprotective activity against B (16) F (10) metastatic melanoma cell line-induced metastasis and could be exploited as one of the potential sources for plant-based pharmaceutical products. [32] Joseph, et al, determined the radioprotective effect of O. sanctum on the salivary gland of rats administered radioiodine (131) I and compared its efficacy with a known radioprotectant, amifostine. Parotid gland histology displayed atrophy with lipomatosis in only (131) I exposed rats.…”

Section: Withania Somnifera (Ashwagandha)mentioning

confidence: 99%

A review of radioprotective plants

Bhandari¹

2013

Int J Green Pharm

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Radioprotective compounds have been used to diminish morbidity or mortality produced by ionizing irradiation. Initial developments of such agents concentrated on thiol synthetic compounds, like amifostine. This agent decreased mortality; however, there were difficulties in administering aminothiols that led to adverse effects. Unfortunately, no ideal, safe synthetic radioprotectors are available to date; hence, the exploration for other sources, including plants, has been ongoing for several decades. A methodical screening strategy can offer leads to isolating prospective novel candidate drugs from plant sources, for alleviation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are extensively used in traditional systems of medicine, and which have rendered noteworthy radioprotection in both in vitro and in vivo model systems.

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“…The plant is considered sacred and is worshipped in a sanctorum of its own in traditional Hindu temples, sacred groves, and households throughout the subcontinent and therefore its taxonomical synonym O. sanctum L. is more popular in Indian scientific literature. A number of recent biochemical and physiological studies indicate that this plant has antidiabetic [2], antimicrobial [3], anticancer [4], adaptogenic [5], and radioprotective [6] properties.…”

Section: Introductionmentioning

confidence: 99%

Chloroplast DNA Phylogeography of Holy Basil (Ocimum tenuiflorum) in Indian Subcontinent

Bast

Rani

Meena

2014

The Scientific World Journal

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Ocimum tenuiflorum L., holy basil “Tulsi”, is an important medicinal plant that is being grown and traditionally revered throughout Indian Subcontinent for thousands of years; however, DNA sequence-based genetic diversity of this aromatic herb is not yet known. In this report, we present our studies on the phylogeography of this species using trnL-trnF intergenic spacer of plastid genome as the DNA barcode for isolates from Indian subcontinent. Our pairwise distance analyses indicated that genetic heterogeneity of isolates remained quite low, with overall mean nucleotide p-distance of 5 × 10−4. However, our sensitive phylogenetic analysis using maximum likelihood framework was able to reveal subtle intraspecific molecular evolution of this species within the subcontinent. All isolates except that from North-Central India formed a distinct phylogenetic clade, notwithstanding low bootstrap support and collapse of the clade in Bayesian Inference. North-Central isolates occupied more basal position compared to other isolates, which is suggestive of its evolutionarily primitive status. Indian isolates formed a monophyletic and well-supported clade within O. tenuiflorum clade, which indicates a distinct haplotype. Given the vast geographical area of more than 3 million km2 encompassing many exclusive biogeographical and ecological zones, relatively low rate of evolution of this herb at this locus in India is particularly interesting.

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Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species ofOcimumin C₅₇BL mice

Cited by 46 publications

References 32 publications

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

A review of radioprotective plants

Chloroplast DNA Phylogeography of Holy Basil (Ocimum tenuiflorum) in Indian Subcontinent

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Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species ofOcimumin C57BL mice

Cited by 46 publications

References 32 publications

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

A review of radioprotective plants

Chloroplast DNA Phylogeography of Holy Basil (Ocimum tenuiflorum) in Indian Subcontinent

Contact Info

Product

Resources

About

Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species ofOcimumin C₅₇BL mice