Antimelanogenesis Effects of Leaf Extract and Phytochemicals from Ceylon Olive (Elaeocarpus serratus) in Zebrafish Model

Huang, Chi Ya; Liu, I-Hsuan; Huang, Xiang Zhe; Chen, Hui Jen; Chang, Shang‐Tzen; Chang, Mei Chi; Ho, Yu Tung; Chang, Hui-Ting

doi:10.3390/pharmaceutics13071059

Cited by 23 publications

(10 citation statements)

References 41 publications

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“…Gallic acid, gallotannin, valonia tannin and extracts of plants (e.g., Ceylon olive leaves and pomegranate peel) containing gallic acid exerted antimelanogenic effects directly by acting as a competitive inhibitor of tyrosinase and indirectly by inhibiting tyrosinase via antioxidant actions that affect melanogenesis pathway in vitro and in vivo ( Chen et al, 2009 ; Panich et al, 2013 ; Su et al, 2013 ; Kanlayavattanakul et al, 2020 ; Huang et al, 2021 ; Liu et al, 2021 ). A randomized, double-blind, placebo-controlled clinical trial demonstrated that continuous administration of apple polyphenol rich in procyanidins for 12 weeks improved UV-induced skin pigmentation in heathy women ( Shoji et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Chaiprasongsuk

Panich

2022

Front. Pharmacol.

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Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and effective preventive and therapeutic strategies for various diseases including skin photoaging and photodamage-related skin problems including abnormal pigmentation and inflammation. Exploring the roles of phytochemicals in mitigating ultraviolet radiation (UVR)-induced skin damage is thus of importance to offer insights into medicinal and ethnopharmacological potential for development of novel and effective photoprotective agents. UVR plays a role in the skin premature aging (or photoaging) or impaired skin integrity and function through triggering various biological responses of skin cells including apoptosis, oxidative stress, DNA damage and inflammation. In addition, melanin produced by epidermal melanocytes play a protective role against UVR-induced skin damage and therefore hyperpigmentation mediated by UV irradiation could reflect a sign of defensive response of the skin to stress. However, alteration in melanin synthesis may be implicated in skin damage, particularly in individuals with fair skin. Oxidative stress induced by UVR contributes to the process of skin aging and inflammation through the activation of related signaling pathways such as the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1), the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), the nuclear factor kappa B (NF-κB) and the signal transducer and activator of transcription (STAT) in epidermal keratinocytes and dermal fibroblasts. ROS formation induced by UVR also plays a role in regulation of melanogenesis in melanocytes via modulating MAPK, PI3K/Akt and the melanocortin 1 receptor (MC1R)-microphthalmia-associated transcription factor (MITF) signaling cascades. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated antioxidant defenses can affect the major signaling pathways involved in regulation of photoaging, inflammation associated with skin barrier dysfunction and melanogenesis. This review thus highlights the roles of phytochemicals potentially acting as Nrf2 inducers in improving photoaging, inflammation and hyperpigmentation via regulation of cellular homeostasis involved in skin integrity and function. Taken together, understanding the role of phytochemicals targeting Nrf2 in photoprotection could provide an insight into potential development of natural products as a promising strategy to delay skin photoaging and improve skin conditions.

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Section: Introductionmentioning

confidence: 99%

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Chaiprasongsuk

Panich

2022

Front. Pharmacol.

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“…The structural determination of isolated compounds was performed by spectral analyses, including 1D NMR (Nuclear magnetic resonance spectroscopy) ( 1 H-NMR, 500 MHz; 13 C-NMR, 125 MHz) and 2D NMR (HSQC, HMBC, COSY, and NOESY) measured on a Bruker AVIII NMR spectrometer (Bruker Avance, Rheinstetten, Germany), FTIR (Fourier transform infrared spectroscopy, FTS-40, Bio-rad, Hercules, CA, USA), and MS (mass spectroscopy, MAT-958, Finnigan, MA, USA) [ 37 , 38 , 39 , 40 ].…”

Section: Methodsmentioning

confidence: 99%

Antifungal Sesquiterpenoids from Michelia formosana Leaf Essential Oil against Wood-Rotting Fungi

Huang

et al. 2022

Molecules

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Michelia formosana (Kanehira) Masamune is a broad-leaved species widespread in East Asia; the wood extract and its constituents possess antifungal activity against wood-decay fungi. Antifungal activities of leaf essential oil and its constituents from M. formosana were investigated in the present study. Bioassay-guided isolation was applied to isolate the phytochemicals from leaf essential oil. 1D and 2D NMR, FTIR, and MS spectroscopic analyses were applied to elucidate the chemical structures of isolated compounds. Leaf essential oil displayed antifungal activity against wood decay fungi and was further separated into 11 fractions by column chromatography. Four sesquiterpenoids were isolated and identified from the active fractions of leaf essential oil through bioassay-guided isolation. Among these sesquiterpenoids, guaiol, bulnesol, and β-elemol have higher antifungal activity against brown-rot fungus Laetiporus sulphureus and white-rot fungus Lenzites betulina. Leaf essential oil and active compounds showed better antifungal activity against L. sulphureus than against L. betulina. The molecular structure of active sesquiterpenoids all contain the hydroxyisopropyl group. Antifungal sesquiterpenoids from M. formosana leaf essential oil show potential as natural fungicides for decay control of lignocellulosic materials.

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“…P. chinensis leaf essential oil (50 g) was further subjected to classical preparative silica gel column chromatography (CC) with a gradient elution of n -hexane and ethyl acetate of increasing polarity, and then separated into six fractions (E1–E6) using thin-layer chromatography (TLC) to analyze the elution profiles at both 254 nm and 365 nm UV light [ 41 , 42 , 43 ].…”

Section: Methodsmentioning

confidence: 99%

Xanthine Oxidase Inhibitory Activity and Chemical Composition of Pistacia chinensis Leaf Essential Oil

Huang

Chang

et al. 2022

Pharmaceutics

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Gout is a common metabolic disease caused by abnormal purine metabolism that promotes the formation and deposition of monosodium urate crystals within joints that causes acute arthritis and can seriously affect the daily life of patients. Pistacia chinensis is one of the traditional medicinal plants of the Anacardiaceae family, and there have been many studies on its biological activity, including anti-inflammatory, antidepressant, antibacterial, antioxidant, and hypoglycemic activities. The aim of this study was to evaluate the antigout effect of P. chinensis leaf essential oil and its constituents through xanthine oxidase inhibition. Leaf essential oil showed good xanthine oxidase inhibitory activity for both substrates, hypoxanthine and xanthine. Six fractions were obtained from open column chromatography, and fraction E1 exhibited the best activity. The constituents of leaf essential oil and fraction E1 were analyzed by GC-MS. The main constituents of both leaf essential oil and fraction E1 were limonene and 3-carene; limonene showed a higher inhibitory effect on xanthine oxidase. Based on the enzyme kinetic investigation, limonene was the mixed-type inhibitor against xanthine oxidase. The results revealed that Pistacia chinensis leaf essential oil and limonene have the potential to act as natural remedies for the treatment of gout.

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Antimelanogenesis Effects of Leaf Extract and Phytochemicals from Ceylon Olive (Elaeocarpus serratus) in Zebrafish Model

Cited by 23 publications

References 41 publications

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Antifungal Sesquiterpenoids from Michelia formosana Leaf Essential Oil against Wood-Rotting Fungi

Xanthine Oxidase Inhibitory Activity and Chemical Composition of Pistacia chinensis Leaf Essential Oil

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