Antimalarial therapy for granuloma annulare: a systematic review

Mostafa, Niyaz; Phan, Kevin; Smith, Saxon D

doi:10.1080/09546634.2020.1801973

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…A 2019 review pooling together the reported cases of antimalarial treatment for GA showed that 25 of 35 patients treated with HCQ, and all of the 12 patients treated with chloroquine, experienced improvement, with an overall response rate of 79.6% [ 64 ]. Since the publication of this review, additional reports have emerged that are more mixed.…”

Section: Review Of Management Optionsmentioning

confidence: 99%

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Joshi

Duvic

2021

Am J Clin Dermatol

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Granuloma annulare (GA) is an inflammatory granulomatous skin disease that can be localized (localized GA) or disseminated (generalized GA), with patch, perforating, and subcutaneous subtypes being less common variants of this benign condition. Recently, new research has emerged that further elucidates GA epidemiology and etiopathogenesis; importantly, new therapeutic options for GA have also been described, although there remains a paucity of randomized controlled studies. In this review, we summarize recent updates on GA epidemiology and etiopathogenesis and offer an updated review of the therapeutic options for GA currently reported in the literature. We hope that the current review galvanizes randomized controlled studies that will in turn help lead to the recommendation of evidence-based treatments for GA.

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Section: Review Of Management Optionsmentioning

confidence: 99%

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Joshi

Duvic

2021

Am J Clin Dermatol

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“…Case studies of antimalarial treatment for GA demonstrated improvement in 25 out of 35 patients treated with hydroxychloroquine, and all 12 patients treated with chloroquine, experienced improvement, with an overall efficacy rate of 79.6%. Mean time of therapy ranged from 2.0 to 22.1 months and dosage ranged between 200 and 400 mg, once or twice daily [106]. Since the publication of aforementioned review, a few case reports and one retrospective analysis have described 2 patients, 1 of which was a pediatric patient, who had complete remission; 2 who had partial resolution, and 1 with persistent GA lesions treated with hydroxychloroquine [107][108][109].…”

Section: Antimalarialsmentioning

confidence: 99%

Granuloma Annulare: A Clinical Update

Kachlik,

Kaczmarek,

Grych

et al. 2024

Curr Derm Rep

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Purpose of Review Granuloma annulare (GA) is a benign, inflammatory granulomatous skin condition that can present as localized, disseminated, subcutaneous, perforating and a few other less prevalent subtypes. While GA may manifest as a self-limited condition, its distinctive feature of mimicking other diseases, and difficulties in distinguishing between subtypes, can add complexity to the diagnostic process. This review was conducted to evaluate the latest published studies and outline the options for GA treatment. Recent Findings Multiple treatment modalities for GA have been reported, including topical and oral treatment along with many procedures, wherefrom phototherapy remains the most well-studied option. Recently new studies have identified Th1, Th2, and JAK- STAT pathways dysregulation in GA skin lesions, and subsequently, promising effects have been reported with Th1, Th2, and JAK- STAT targeting therapy for GA. Summary There is still no gold standard for clinical management of GA. Evidence-based treatment recommendations derived from randomized control trials are scarce, since the majority of published research is confined to case reports, case series, and singular retrospective studies. Therapeutic approach may vary depending on the clinical subtype of GA, necessitating individualization based on patients preferences, possible side effects and risk-benefit ratio.

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Heterogene Klinik - anspruchsvolle Therapie

Wenzel¹

2021

Dtsch Dermatolog

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Antimalarial therapy for granuloma annulare: a systematic review

Cited by 3 publications

References 10 publications

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Granuloma Annulare: A Clinical Update

Heterogene Klinik - anspruchsvolle Therapie

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