Antimalarial Phenanthroindolizine Alkaloids from &lt;i&gt;Ficus septica&lt;/i&gt;

Kubo, Miwa; Wataru, Yatsuzuka; Matsushima, Shoko; Harada, Kenichi; Inoue, Yusuke; Miyamoto, Hisashi; Matsumoto, Makoto; Fukuyama, Yoshiyasu

doi:10.1248/cpb.c16-00181

Cited by 26 publications

(28 citation statements)

References 18 publications

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“…e structures of some phenanthroindolizine alkaloids with promising antiplasmodial activity are shown in Figure 3. Kubo et al [32] isolated a new seco-phenanthroindolizine alkaloid, 4a,b-seco-dehydroantofine (21), and three known phenanthroindolizine alkaloids, dehydrotylophorine (22), dehydroantofine (23), and tylophoridicine D (24), from the twigs of Ficus septica. While compound 21 exhibits a moderate antimalarial activity against the 3D7 strain of P. falciparum with IC 50 value 4.0 μM, the known alkaloids (22)(23)(24) Figure 4.…”

Section: Phenanthroindolizine Alkaloidsmentioning

confidence: 99%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

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Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.

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Section: Phenanthroindolizine Alkaloidsmentioning

confidence: 99%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

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“…Bioassay-directed separation of the MeOH extract of the twigs of Ficus septica afforded three known phenanthroindolizine alkaloids, dehydrotylophorine ( 115 ), dehydroantofine ( 116 ) and tylophoridicine D ( 117 ) by Kubo et al ( Figure 25 ) [ 60 ]. They showed antiplasmodial activity against the P. falciparum 3D7 strain with IC 50 values in the range of 0.03–0.4 µM.…”

Section: Plant-derived Antimalarial Compoundsmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan

Shi

et al. 2018

IJMS

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled “Antimalarial activity of plant metabolites” by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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“…Among them, compounds of ficuseptine, 4,6-bis-(4-methoxyphenyl)-1,2,3-trihydroindolizidinium chloride and antofine isolated from methanolic extracts of F. septica leaves showed strong antibacterial and antifungal activities (Baumgartner et al, 1990). In addition, some alkaloids, including dehydrotylophorine, dehydroantofine and tylophoridicine, isolated from methanolic extracts of F. septica twigs showed antimalarial activity (Kubo et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Ficus septicaplant extracts for treating Dengue virusin vitro

Huang

Hung

Tsai

et al. 2017

PeerJ

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Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the Flaviviridae. DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plants in vitro; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem from Ficus septica Burm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelope picornavirus, Aichi virus, was not inhibited by treatment with F. septica extracts. F. septica may be a candidate antiviral drug against an enveloped virus such as DENV.

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Antimalarial Phenanthroindolizine Alkaloids from <i>Ficus septica</i>

Cited by 26 publications

References 18 publications

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Antimalarial Activity of Plant Metabolites

Ficus septicaplant extracts for treating Dengue virusin vitro

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