<i>Ficus septica</i>plant extracts for treating Dengue virus<i>in vitro</i>

Huang, Nan Chieh; Hung, Wan Ting; Tsai, Wan-Ting; Lai, Feng Yi; Lin, You Sheng; Huang, Mei Shu; Chen, Jih Jung; Lin, Weihong; Weng, Jing Ru; Chang, Tsun-Hsu

doi:10.7717/peerj.3448

Cited by 21 publications

(14 citation statements)

References 21 publications

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“…On the other hand, Sood et al. (2015) studied the use of Cissampelos pariera and Ficus septica (Huang et al., 2017) have a potent antiviral activity against dengue virus. Similarly, Castillo Maldonado et al.…”

Section: Discussionmentioning

confidence: 99%

Antidengue potential of leaf extracts of Pavetta tomentosa and Tarenna asiatica (Rubiaceae) against dengue virus and its vector Aedes aegypti (Diptera: Culicidae)

Pratheeba

Taranath

Gopal

2019

Heliyon

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The aim of the present study was to screen the anti-dengue potential of crude leaf extracts of two plants from Pavetta tomentosa and Tarenna asiatica. For larvicidal assay, the acetone extract of both plants showed maximum effects, with the least LC50 and LC90 values (P. tomentosa (5.968 and 7.493 μg/ml) and T. asiatica (1.288 and 1.992 μg/ml)) and the same extract of both plants exhibited better pupicidal potency. The adulticidal activity of both plants (0–60 min interval periods) recorded best results in acetone extracts and the LC50 and LC90 values were recorded as P. tomentosa (32.105 and 41.001 μg/ml) and T. asiatica (09.012 and 11.854 μg/ml). Among the two plants P. tomentosa acetone leaf extract have good antiviral property against Dengue viral cell line. In addition, the phytochemical nature of the plant reveals the presence of saponins, flavonoids and alkaloids in all the tested extracts of both plants. GC-MS analysis revealed Hexanedioic acid, Bis(2-Ethylhexyl) Ester (22.54) and 2,6,10,14,18,22- Tetracosahexane, 2,6,10, 15, 19,15,19,23- Hexamethyl-(ALL-E)- (25.33) identified as two major phytoconstitutents in P. tomentosa and Tetracontane (23.580) is a major compound identified from T. asiatica acetone extracts. The functional groups of chemical compounds (aromatis, alkanes, alkyls and carboxylic acids) from P. tomentosa and T. asiatica were analyzed by FT-IR spectrum.

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Section: Discussionmentioning

confidence: 99%

Antidengue potential of leaf extracts of Pavetta tomentosa and Tarenna asiatica (Rubiaceae) against dengue virus and its vector Aedes aegypti (Diptera: Culicidae)

Pratheeba

Taranath

Gopal

2019

Heliyon

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“…The contamination from soil bacterium should be eliminated as much as possible. The different parts of the plants were then extracted using different solvents, as described previously [38]. Briefly, various plants were ground, extracted with 5 mL of the indicated solvents, such as methanol, chloroform, and acetone, for 1 week.…”

Section: Methodsmentioning

confidence: 99%

Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells

Chang

Liu

Tsai

et al. 2019

Toxins

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Autophagy is an evolutionarily conserved pathway to degrade damaged proteins and organelles for subsequent recycling in cells during times of nutrient deprivation. This process plays an important role in tumor development and progression, allowing cancer cells to survive in nutrient-poor environments. The plant kingdom provides a powerful source for new drug development to treat cancer. Several plant extracts induce autophagy in cancer cells. However, little is known about the role of plant extracts in autophagy inhibition, particularly autophagy-related (ATG) proteins. In this study, we employed S-tagged gamma-aminobutyric acid receptor associated protein like 2 (GABARAPL2) as a reporter to screen 48 plant extracts for their effects on the activity of autophagy protease ATG4B. Xanthium strumarium and Tribulus terrestris fruit extracts were validated as potential ATG4B inhibitors by another reporter substrate MAP1LC3B-PLA2. The inhibitory effects of the extracts on cellular ATG4B and autophagic flux were further confirmed. Moreover, the plant extracts significantly reduced colorectal cancer cell viability and sensitized cancer cells to starvation conditions. The fruit extract of X. strumarium consistently diminished cancer cell migration and invasion. Taken together, the results showed that the fruit of X. strumarium may have an active ingredient to inhibit ATG4B and suppress the proliferation and metastatic characteristics of colorectal cancer cells.

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“…The chloroform fraction had an anti-HCV activity with IC 50 5.67 ± 1.54 µg/ml, while butanol fraction gave lower activity (IC 50 74.10 ± 18.24 µg/ml) (Ha id et al, 2016). Methanol leaves extract of F. septica had antiviral activity against Dengue virus (DENV-1 and DENV-2) with IC 50 13.3±2.6 µg/ml and 10.6±1.1 µg/ml (Huang et al, 2017).…”

Section: Antiviral Activitymentioning

confidence: 97%

A review of the phytochemical compounds and pharmacological activities from selected Ficus plants

Insanu

Santoso

Fidrianny

2020

ijrps

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The Ficus genus belongs to the Moraceae family were used for medicinal purposes. Distributed in America, Asia, Africa, and Australia, there were sixteen species accepted in Indonesia. They were Ficus callosa, Ficus melinocarpa, Ficus elastica, Ficus drupaceae, Ficus geocarpa, Ficus Superba, Ficus heteropoda, Ficus fistulosa, Ficus hirta, Ficus ampelas, Ficus adenosperma, Ficus ardisioides, Ficus consociate, Ficus ribes, Ficus lyrata, Ficus virens Aiton. This article reviewed the scientific work of the Ficus genus. Their traditional usage, phytochemical compounds, and pharmacological activity were summarized. This study aims at providing a collection of publications on selected species of Ficus genus. A critical review of the literature data revealed secondary metabolite like triterpenoid, steroid, saponin, flavonoid, phenolic compound and alkaloid were found in some species of Ficus. Some pure compounds such as quercetin, quercetin 3-O-α-L-arabinopyranoside, epilupeol acetate, oleanolic acid, friedelin, elastiquinone, pinocembrin-7-O-β-D-glucoside, and ficusoside B were isolated. A wide range of pharmacological activities was observed. Antimicrobial, antioxidant, antiviral, antiparasitic, cytotoxic, and antimalarial were found in previous researches. Ficus genus was potential to be developed as a medicinal plant.

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Ficus septicaplant extracts for treating Dengue virusin vitro

Cited by 21 publications

References 21 publications

Antidengue potential of leaf extracts of Pavetta tomentosa and Tarenna asiatica (Rubiaceae) against dengue virus and its vector Aedes aegypti (Diptera: Culicidae)

Antidengue potential of leaf extracts of Pavetta tomentosa and Tarenna asiatica (Rubiaceae) against dengue virus and its vector Aedes aegypti (Diptera: Culicidae)

Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells

A review of the phytochemical compounds and pharmacological activities from selected Ficus plants

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