Antimalarial Compounds Containing an α, β-Unsaturated Carbonyl Moiety from Tanzanian Medicinal Plants<sup>1</sup>

Weenen, Hugo; Nkunya, Mayunga H.H.; Bray, Dorothy; Mwasumbi, Leonard; Kinabo, L. S.; Kilimali, V.A.E.B.; Wijnberg, J. B. P. A.

doi:10.1055/s-2006-960985

Cited by 126 publications

(80 citation statements)

References 5 publications

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“…Achillea, Anacyclus, Artemisia, Leucocyclus, Chamaemelum, Cladanthus, Argyranthemum and Matricaria) (Christensen, 1992). Since then however, those fatty acid moieties are also found in the Heliantheae tribe and other families: Rutaceae, Piperaceae, Aristolochiaceae and Menispermacea (AndradeNeto et al, 1996;Burden and Crombie, 1969;Greger et al, 1981;Greger and Werner, 1990;Saadali et al, 2001;Weenen et al, 1990b;Yasuda et al, 1981a). Nevertheless, the thiophene fatty acid moiety is a typical characteristic of Anthemideae, which was identified in e.g.…”

Section: Q10mentioning

confidence: 99%

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Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

129

109

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a b s t r a c tEthnopharmacological relevance: N-Alkylamides (NAAs) are a promising group of bioactive compounds, which are anticipated to act as important lead compounds for plant protection and biocidal products, functional food, cosmeceuticals and drugs in the next decennia. These molecules, currently found in more than 25 plant families and with a wide structural diversity, exert a variety of biologicalpharmacological effects and are of high ethnopharmacological importance. However, information is scattered in literature, with different, often unstandardized, pharmacological methodologies being used. Therefore, a comprehensive NAA database (acronym: Alkamid) was constructed to collect the available structural and functional NAA data, linked to their occurrence in plants (family, tribe, species, genus). Materials and methods: For loading information in the database, literature data was gathered over the period 1950-2010, by using several search engines. In order to represent the collected information about NAAs, the plants in which they occur and the functionalities for which they have been examined, a relational database is constructed and implemented on a MySQL back-end. Results: The database is supported by describing the NAA plant-, functional-and chemical-space. The chemical space includes a NAA classification, according to their fatty acid and amine structures. Conclusions: The Alkamid database (publicly available on the website http://alkamid.ugent.be/) is not only a central information point, but can also function as a useful tool to prioritize the NAA Q8 choice in the evaluation of their functionality, to perform data mining leading to quantitative structure-property relationships (QSPRs), functionality comparisons, clustering, plant biochemistry and taxonomic evaluations.

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Section: Q10mentioning

confidence: 99%

“…From different studies, it was suggested that the a,b-unsaturated carbonyl function rather than the N-isobutyl substituent is the responsible active site (Penali et al, 2007;Sittie et al, 1998;Weenen et al, 1990a). Longer, straight chain acid moieties and substituted (rather than primary) amines seem advantageous.…”

Section: Antimicrobial and Related Activitiesmentioning

confidence: 99%

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

129

109

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“…Espécies do gênero Zanthoxylum são utilizadas na medicina popular no tratamento de doenças cardiovasculares, tuberculose, malária, para aliviar dor de dente, contra mordida de cobra e como analgésico (Weenen et al, 1990;Arruda et al, 1992;Gessler et al, 1994;Vigneron et al, 2005). Investigações fi toquímicas identifi caram alcalóides, fl avonóides, cumarinas, lignanas e terpenos no gênero (Talapatra et al, 1973;Stermitz;Sharifi , 1977;Diehl et al, 2000;Oliveira et al, 2002;Facundo et al, 2005;Tane et al, 2005).…”

Section: Introductionunclassified

Atividades farmacológicas dos extratos de Zanthoxylum chiloperone (Rutaceae)

Villalba¹,

Carmo²,

Leite³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Neste trabalho foram avaliadas as atividades antinociceptiva e antiinfl amatória dos extratos das folhas de Zanthoxylum chiloperone. Os ensaios foram realizados pelos testes de contorções abdominais induzidas por ácido acético, tempo da lambida da pata induzida por formalina, edema de pata e pleurisia induzidas por carragenina, usando os extratos hexânico, em acetato de etila e etanólico administrados nas doses de 100 e 200 mg/kg. As doses testadas reduziram, signifi cativamente, as contorções abdominais, o tempo de lambida da pata, o edema de pata, o volume do exsudato e a migração leucocitária. Estes resultados sugerem que os extratos de Z. chiloperone possuem constituintes com atividades antinociceptiva e antiinfl amatória.Unitermos: Zanthoxylum chiloperone, atividade antinociceptiva, atividade antiinfl amatória.ABSTRACT: "Pharmacological activities of Zanthoxylum chiloperone (Rutaceae) extracts". In this work the antinociceptive and anti-infl ammatory activities of the extracts of leaves from Zanthoxylum chiloperone were evaluated. The tests were carried out by acetic acid writhing, formalin-induced paw licking, carrageenan-induced rat paw edema and pleurisy methods, using hexane, ethyl acetate and ethanol extracts administered in the doses of 100 and 200 mg/kg. The doses inhibited, signifi cantly, the contortions, the paw lick, the paw edema, the volume of the exsudate and the leukocytes migration. These results suggest that the extracts from Z. chiloperone possess constituents with antinociceptive and anti-infl ammatory activities.

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“…Investigações fitoquímicas anteriores de espécies deste gênero revelaram a presença de alcalóides, flavonóides, cumarinas, lignanas e terpenos [2][3][4][5] . Vá-rias destas espécies são utilizadas na medicina popular no tratamento de doenças cardiovasculares, tuberculose, malária, para aliviar dor de dente e contra mordida de cobra [6][7][8][9] . O estudo fitoquímico de duas espécies comuns do nordeste do Brasil, Z. syncarpum e Z. rugosum, conduziu ao isolamento dos metabólitos secundários skimianina, cis-N-metilcanadina, isopimpinelina, xantotoxina, lupeol, ácido centipédico, 3β-O-β-D-glucopiranosil-sitosterol, 6-cantinona, 6,7-dimetoxicumarina, 6,7,8-trimetoxicumarina, avicenina, hesperidina, ácido 3-(9H-β-carbolina-1-il)-(Z)-2-propenóico e 2-hidróxi-2-(4-hidroxifenil)etil (trimetil) amônio 10,11 .…”

Section: Introductionunclassified

Constituintes químicos de Zanthoxylum ekmanii (URB.) Alain

Facundo¹,

Silveira²,

Braz-Filho³

et al. 2005

Quím. Nova

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Recebido em 17/2/04; aceito em 9/9/04; publicado na web em 17/2/05 CHEMICAL CONSTITUENTS OF Zanthoxylum ekmanii (URB.) ALAIN. Chemical investigation of Z. ekmanii resulted in the isolation of skimmianine, dictamnine, tembamide, sesamin, lupeol and β-sitosterol. The structures were established by spectroscopic analyses. This is the first report on the phytochemical study of the roots and leaves of Z. ekmanii .

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Antimalarial Compounds Containing an α, β-Unsaturated Carbonyl Moiety from Tanzanian Medicinal Plants¹

Cited by 126 publications

References 5 publications

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Atividades farmacológicas dos extratos de Zanthoxylum chiloperone (Rutaceae)

Constituintes químicos de Zanthoxylum ekmanii (URB.) Alain

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Antimalarial Compounds Containing an α, β-Unsaturated Carbonyl Moiety from Tanzanian Medicinal Plants1

Cited by 126 publications

References 5 publications

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Atividades farmacológicas dos extratos de Zanthoxylum chiloperone (Rutaceae)

Constituintes químicos de Zanthoxylum ekmanii (URB.) Alain

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Antimalarial Compounds Containing an α, β-Unsaturated Carbonyl Moiety from Tanzanian Medicinal Plants¹