Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp. BCC45596

Supong, Khomsan; Thawai, Chitti; Suwanborirux, Khanit; Choowong, Wilunda; Supothina, Sumalee; Pittayakhajonwut, Pattama

doi:10.1016/j.phytol.2012.06.015

Cited by 45 publications

(25 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supong and colleagues reported a novel C -glycosylated benz[ a ]anthraquinone derivative, urdamycinone E ( 78 ) isolated from a marine Streptomyces sp. BCC45596 that potently inhibited P. falciparum K1 strain [84]. …”

Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

“…Avilés and colleagues isolated two new tricyclic diterpenes ( 91 , 92 ) from the Bahamian marine sponge Svenzea flava that displayed moderate antimycobacterial activity against M. tuberculosis H37Rv, the data suggesting that “the isoneoamphilectane backbone” may be “responsible for the observed activity” [95]. In addition to the antimalarial activity described earlier, Supong and colleagues reported that the novel C -glycosylated benz[ a ]anthraquinone derivative, urdamycinone E ( 78 ), inhibited M. tuberculosis strain H37Rv [84]. …”

Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

See 1 more Smart Citation

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2017

View full text Add to dashboard Cite

The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012–2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.

show abstract

Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Yang and coworkers [100] reported the isolation of anthraquinone derivative, 3-acetoxy-4-deoxybostrycin ( Figure 23.10), from a marine-derived fungus Nigrospora, which exhibited promising activity against B. cereus with an MIC value of 48.8 nM, which was stronger than that of the positive control ciprofloxacin (MIC ¼ 1250 nM). C-glycosylated benz[a]anthraquinone derivatives [101], urdamycinone E, urdamycinone G, dehydroxyaquayamycin ( Figure 23.10), isolated from the marine Streptomycetes sp. exhibited potent activity against M. tuberculosis MICs of 3.13e12.50 mg/mL.…”

Section: Antimicrobial Agents From Marine Sourcesmentioning

confidence: 99%

Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay

Rahman

2015

Evidence-Based Validation of Herbal Medicine

View full text Add to dashboard Cite

“…Appendices N-Q) allowed to support the presence of dehydroxyaquayamycin by comparison against reported data(Supong et al, 2012). HR-ESI-MS of this sample resulted in…”

mentioning

confidence: 89%

“…Data1:SA-A3-X11-5- 31 dehydroxyaquayamycin. This metabolite was previously described as natural product from marine actinobacteria (Supong et al, 2012), originally obtained as dehydrated product of aquayamycin during its structure elucidation (Sezaki et al, 1970). Data12:SA-A3-X11-5-2.lcd PDA Ch12 420nm,4nm…”

Section: Measurement Of Colony Areasmentioning

confidence: 99%

Elicitation of natural products biosynthesis from endophytic microorganisms´ interactions

Rodríguez¹,

Mauricio²

View full text Add to dashboard Cite

CARABALLO-RODRÍGUEZ, A. M. Elicitation of natural products biosynthesis from endophytic microorganisms´ interactions. 2016. 169 p. Doctoral Dissertation. School of Pharmaceutical Sciences of Ribeirão Preto -University of São Paulo, Ribeirão Preto, 2016. In order to continue with the study of natural products from previously isolated endophytes of the Brazilian medicinal plant Lychnophora ericoides, the main goal of this work focused on the metabolic exchange of endophytic microorganisms from this plant. As it has been demonstrated during the last years, elicitation of different molecules is consequence of microbial interactions, mainly due to the need to compete, survive and establish microbial communities in shared environments. Recent mass spectrometry related approaches, such as imaging and molecular networking, in combination with purification and structural elucidation were applied to the current study of the microbial interactions of endophytes. During this study, several chemical families were identified, such as polyene macrocycles, pyrroloindole alkaloids, leupeptins, angucyclines, siderophores, amongst others. Amongst the polyene macrocycles, the well-known antifungal amphotericin B was identified as a biosynthetic product of the endophytic actinobacteria Streptomyces albospinus RLe7. When S. albospinus RLe7 interacted with an endophytic fungus, Coniochaeta sp. FLe4, a red pigmentation was observed. A new fungal compound was detected from microbial interactions. Isolation and structure elucidation of this new compound enabled to demonstrate the elicitation of fungal secondary metabolites by amphotericin B, an actinobacterial metabolite. It was also demonstrated the elicitation of griseofulvin and its analogue dechlorogriseofulvin from another endophytic fungus, FLe9, as a consequence of exposition to amphotericin B. In addition, investigation of the chemical profile of another endophytic actinobacteria, S. mobaraensis RLe3, led to reveal this strain as angucycline-derivatives producer. Besides that, coculturing of this actinobacteria against Coniochaeta sp. FLe4 also demonstrated elicitation of angucycline analogues. In conclusion, this study demonstrated elicitation of natural products from microbial interactions as well as new compounds from endophytes from L. ericoides and contributed to the identification of microbial metabolites. RESUMO CARABALLO-RODRÍGUEZ, A. M. Eliciação da biossíntese de produtos naturais a partir da interação de microorganismos endofíticos. 2016. 169 f. Tese de doutorado, Faculdade de Ciências Farmacêuticas de Ribeirão Preto -Universidade de São Paulo, Ribeirão Preto, 2016. Com o propósito de continuar com os estudos de produtos naturais de microorganismos endofíticos da planta medicinal Brasileira Lychnophora ericoides, o principal objetivo desse trabalho focou-se no estudo da troca metabólica de microorganismos endofíticos dessa planta. Como tem sido demonstrado durante os últimos anos, a elicitação de diferentes compostos é consequência das interações microbianas, principalm...

show abstract

Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp. BCC45596

Cited by 45 publications

References 25 publications

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay

Elicitation of natural products biosynthesis from endophytic microorganisms´ interactions

Contact Info

Product

Resources

About