1980
DOI: 10.1001/archderm.116.5.587
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Antimalarial agents. Chloroquine, hydroxychloroquine, and quinacrine

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Cited by 84 publications
(54 citation statements)
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“…7) and low IC 50 s (Table 2) in field isolates. QC was the antimalarial drug of choice prior to CQ and is structurally similar to CQ, save for an additional benzene ring (33). Both CQ and QC are known to bind to heme and inhibit its degradation and detoxification (34).…”
Section: Discussionmentioning
confidence: 99%
“…7) and low IC 50 s (Table 2) in field isolates. QC was the antimalarial drug of choice prior to CQ and is structurally similar to CQ, save for an additional benzene ring (33). Both CQ and QC are known to bind to heme and inhibit its degradation and detoxification (34).…”
Section: Discussionmentioning
confidence: 99%
“…As far as is known, chloroquine forms complexes with gangliosides, inhibiting further degradation [38] and finally leading to an accumulation of lipid complexes in the neuroretina [39,40]. Ultimately this may cause irreversible damage to rods and cones even after cessation of the drug [41,42].…”
Section: Toxicitymentioning
confidence: 99%
“…Adverse effects are relatively uncommon when chloroquine is used for antimalarial chemoprophylaxis and they usually develop after long-term administration. Although epidemiological studies did not confirm chloroquine as a cause of agranulocytosis and/or bone marrow aplasia (1,2), chloroquine is nevertheless listed among myelotoxic drugs (3)(4)(5)(6). Moderate neutropenia has been reported in 4.8% of rheumatoid patients treated with 250 mg chloroquine daily for over 1 year (7).…”
Section: Discussionmentioning
confidence: 99%