Antimalarial activity of substituted anthraquinones

Heiga, L A Abu el; Katzhendler, Jehoshua; Gean, K.F.; Bachrach, Uriel

doi:10.1016/0006-2952(90)90531-o

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Several anthraquinones extracted from different plant parts strongly inhibited in vitro growth of a chloroquine sensitive strain of Plasmodium falciparum (3D7) [57]. Anthraquinones may generate reactive oxygen and thus inactivate malaria parasites ( Plasmodium falciparum, P. vinckei and P. berghei ) [58, 59]. Latex leaf extract of Aloe citrine showed antiplasmodial activity due to presence of anthrone, homonataloin A/B as a major constituent [60].…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

Kumar

Yadav

et al. 2017

BMC Complement Altern Med

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BackgroundIn this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of crude aqueous extracts was done to estimate the effects of these constituents on antiplasmodial potential of the plant.MethodsHPTLC system equipped with a sample applicator Linomat V with CAMAG sample syringe, twin rough plate development chamber (20 x 10 cm), TLC Scanner 3 and integration software WINCATS 1.4.8 was used for analysis of aloin and aloe-emodin amount. The antiplasmodial activity of plant extracts was assessed against a chloroquine (CQ) sensitive strain of P. falciparum (MRC-2). Minimum Inhibitory Concentration (MIC) of aqueous extracts of selected samples was determined according to the World Health Organization (WHO) recommended method that was based on assessing the inhibition of schizont maturation in a 96-well microtitre plate. EC (effective concentration) values of different samples were observed to predict antiplasmodial potential of the plant in terms of their climatic zones.ResultsA maximum quantity of aloin and aloe-emodin i.e. 0.45 and 0.27 mg/g respectively was observed from the 12 samples of Aloe vera. The inhibited parasite growth with EC50 values ranging from 0.289 to 1056 μg/ml. The antiplasmodial EC50 value of positive control Chloroquine was observed 0.034 μg/ml and EC50 values showed by aloin and aloe-emodin was 67 μg/ml and 22 μg/ml respectively. A positive correlation was reported between aloin and aloe-emodin. Antiplasmodial activity was increased with increase in the concentration of aloin and aloe-emodin. The quantity of aloin and aloe-emodin was decreased with rise in temperature hence it was negatively correlated with temperature.ConclusionsThe extracts of Aloe vera collected from colder climatic regions showed good antiplasmodial activity and also showed the presence of higher amount of aloin and aloe-emodin in comparison to collected from warmer climatic sites. Study showed significant correlation between quantities of both the anthraquinones used as marker compounds and EC50 values of the different Aloe vera extracts. Although, both the anthraquinones showed less antiplasmodial potential in comparison to crude extracts of different Aloe vera samples. Diverse climatic factors affect the quantity of tested compounds and antiplasmodial potential of the plant in different Aloe vera samples.

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Section: Discussionmentioning

confidence: 99%

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

Kumar

Yadav

et al. 2017

BMC Complement Altern Med

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“…It is hypothesised that anthraquinones may act as antiplasmodial agents through futile redox cycling, similar to naphthoquinones [62,65,66]. They generally serve as a catalytic oxidising agent capable of undergoing cyclic one electron oxidation-reduction reactions [62].…”

Section: Possible Mode Of Action Of Anthraquinones As Antiplasmodial mentioning

confidence: 99%

Antiplasmodial Anthraquinones from Medicinal Plants: The Chemistry and Possible Mode of Actions

Osman

Ismail

2018

Natural Product Communications

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Malaria killed nearly half a million people in 2015, and 70% of this victims were young children. Malarial chemotherapy makes use of several drugs, each with its own pharmacological limitations, and with parasite resistance being the most challenging. People of low income nations often rely on traditional medicine as a treatment due to limited access to modern healthcare services. Despite uncertainties present in the outcome of traditional medicine, ethnomedicine approach has yielded important lead candidates. The investigation of medicinal plants utilized in the malaria endemic region yielded many antiplasmodial compounds with anthraquinone moiety. This paper describes natural anthraquinones extracted from medicinal plants utilized in traditional medicine for the treatment of malaria. In addition, the insight on structure-activity relationship and their mode of actions are also elaborated.

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“…Due to their diverse biological activities, 9,10-anthraquinones are receiving growing attention. They were reported to possess antiviral [ 3 ], antibacterial [ 4 ], antifungal [ 5 ], protein cleaving [ 6 ], anticancer [ 7 ], and antimalarial [ 8 , 9 ] properties, for example. Among the 450 genera of Rubiaceae, the genus Pentas became known for its rich anthraquinone and pyranonaphthoquinone content [ 10 ], which is responsible for the antiplasmodial activity of the root extracts of some of its species [ 11 ] that are regularly utilized in the Kenyan indigenous medicine for the treatment of malaria [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Anthraquinones of the Roots of Pentas micrantha

et al. 2012

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Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 μg/mL) and D6-strains (4.00 μg/mL) of Plasmodium falciparum and low cytotoxicity (>450 μg/mL, MCF-7 cell line). Chromatographic separation of the extract yielded nine anthraquinones, of which 5,6-dihydroxylucidin-11-O-methyl ether is new. Isolation of a munjistin derivative from the genus Pentas is reported here for the first time. The isolated constituents were identified by NMR and mass spectrometric techniques and showed low antiplasmodial activities.

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Antimalarial activity of substituted anthraquinones

Cited by 6 publications

References 24 publications

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

Antiplasmodial Anthraquinones from Medicinal Plants: The Chemistry and Possible Mode of Actions

Anthraquinones of the Roots of Pentas micrantha

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