Anthraquinones of the Roots of Pentas micrantha

Endale, Milkyas; Ekberg, Anders; Alao, John P.; Akala, Hoseah M.; Ndakala, Albert; Sunnerhagen, Per; Erdélyi, Máté; Yenesew, Abiy

doi:10.3390/molecules18010311

Cited by 23 publications

(25 citation statements)

References 26 publications

(50 reference statements)

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“…13 (12) 2018 1593with IC 50 values within the range of 20-70µM. The compounds exhibited a form mild toxicity with CC 50 values within the range of 100-500µmol/mL[44]. The examination of P. lanceolata resulted in the isolation of rubiadin 8, damnacanthal 14, nordamnacanthal 15, lucidin-ɷ-methyl ether 18, tectoquinone 20, damnacanthol 21, rubiadin-1-methyl ether 22, and 5,6-dihydroxydamnacanthol 23 which exhibited a moderate antiplasmodial activity (W2 and D6 strains) with the IC 50 values within the range of 5-31µg/mL.…”

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confidence: 99%

Antiplasmodial Anthraquinones from Medicinal Plants: The Chemistry and Possible Mode of Actions

Osman

Ismail

2018

Natural Product Communications

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Malaria killed nearly half a million people in 2015, and 70% of this victims were young children. Malarial chemotherapy makes use of several drugs, each with its own pharmacological limitations, and with parasite resistance being the most challenging. People of low income nations often rely on traditional medicine as a treatment due to limited access to modern healthcare services. Despite uncertainties present in the outcome of traditional medicine, ethnomedicine approach has yielded important lead candidates. The investigation of medicinal plants utilized in the malaria endemic region yielded many antiplasmodial compounds with anthraquinone moiety. This paper describes natural anthraquinones extracted from medicinal plants utilized in traditional medicine for the treatment of malaria. In addition, the insight on structure-activity relationship and their mode of actions are also elaborated.

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confidence: 99%

Antiplasmodial Anthraquinones from Medicinal Plants: The Chemistry and Possible Mode of Actions

Osman

Ismail

2018

Natural Product Communications

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“…[1920] For example, several anthraquinones isolated from the root extract of Rennellia elliptica Korth were found to inhibit strongly in vitro growth of a chloroquine sensitive strain of P. falciparum (3D7). [21] Similarly, aloe saponarin I isolated from A. saponaria has been reported to possess a good antiplasmodial activity against the P. falciparum Dd2.…”

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confidence: 99%

Antimalarial evaluation of the leaf latex of Aloe citrina and its major constituent

2015

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Background:Malaria is one of the major obstacles to the socioeconomic development of several developing countries. Adequate treatment of the disease is becoming increasingly difficult due to the worsening problems of drug resistance in many parts of the world. Therefore, increased efforts in antimalarial drug discovery are urgently needed.Objectives:This study was designed to evaluate the antimalarial activity of the leaf latex of Aloe citrina Carter and Brandham and its major constituent.Materials and Methods:The leaf latex of A. citrina was dissolved in methanol and subjected to preparative thin layer chromatography. Structure of the isolated compound was determined on the basis of its electrospray-ionization tandem mass spectrometry, 1H, 13C NMR and DEPT spectral data. The latex and its isolated compound were tested for their in vivo antimalarial activity using a 4-day suppressive test against chloroquine sensitive ANKA strain of Plasmodium berghei in mice.Results:Homonataloin A/B was isolated as a major component of the latex. Both the latex and isolated compound exhibited significant (P < 0.001) antimalarial activity at a dose of 400 mg/kg with parasite suppression of 60.59% and 67.52%, respectively. No significant adverse signs of toxicity were observed in mice treated with the leaf latex up to the highest dose (5000 mg/kg).Conclusion:The results of this study indicate that the antimalarial activity of the plant is attributed in part or in full to the presence of homonataloin A/B in the latex. It also validates the traditional use of the plant as an antimalarial agent.

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“…The structure of compound 3a was determined by a comparison with the spectral data of the reported compound. 13 The 1 H NMR spectrum of 3a showed a characteristic methyl peak on the benzene ring at d = 2.45 ppm as a singlet, whereas a methyl carbon peak was observed in the 13 C NMR spectrum at d = 21.8 ppm.…”

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Organocatalyzed benzannulation for the construction of diverse anthraquinones and tetracenediones

2015

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An efficient one-pot synthesis of anthraquinones and tetracenediones was achieved via L-proline catalyzed [4+2] cycloaddition of in situ generated azadiene from α,β-unsaturated aldehydes and 1,4-naphthoquinones or 1,4-anthracenedione in good to excellent yield. This protocol constitutes an unprecedented tandem benzannulation that allows one-pot construction of diverse anthraquinones and tetracenediones in the presence of organocatalysts. This methodology was applied successfully to the synthesis of naturally occurring molecules and photochemically interesting phenanthrenequinone derivatives.

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Anthraquinones of the Roots of Pentas micrantha

Cited by 23 publications

References 26 publications

Antiplasmodial Anthraquinones from Medicinal Plants: The Chemistry and Possible Mode of Actions

Antiplasmodial Anthraquinones from Medicinal Plants: The Chemistry and Possible Mode of Actions

Antimalarial evaluation of the leaf latex of Aloe citrina and its major constituent

Organocatalyzed benzannulation for the construction of diverse anthraquinones and tetracenediones

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