Antimalaria Drug Development &amp; Pipeline

Lahiry, Sandeep; eep,; Sinha, Rajasree

doi:10.15406/japlr.2017.05.00136

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…7). 111 Biosurfactants possess certain interesting physicochemical properties by which they can maintain their integrity while being delivered as an aerosol. This mode of delivery endows biosurfactants with a drug carrier-like feature considering the lungs as the main area of action.…”

Section: Biosurfactantsmentioning

confidence: 99%

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COVID-19 mitigation: nanotechnological intervention, perspective, and future scope

Adhikari¹,

Mandal²,

Rana³

et al. 2023

Mater. Adv.

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Section: Biosurfactantsmentioning

confidence: 99%

“…The amphiphilic structure of biosurfactant suggests, that the water-fearing layer can react with the lipid layer of the virus, as concomitantly reacting with hydrophobic substances like H 2 O. This unique amphiphilic nature is the cornerstone of biosurfactant structure which is very beneficial to disrupt virus structure 111.…”

mentioning

confidence: 99%

COVID-19 mitigation: nanotechnological intervention, perspective, and future scope

Adhikari¹,

Mandal²,

Rana³

et al. 2023

Mater. Adv.

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“…[ 176 ] A simpler metabolism, low toxicity, and amodiaquine‐like activity were shown by GSK369796; however, the compound was not found to be as effective as chloroquine. [ 177,178 ]…”

Section: Malariamentioning

confidence: 99%

“…[176] A simpler metabolism, low toxicity, and amodiaquine-like activity were shown by GSK369796; however, the compound was not found to be as effective as chloroquine. [177,178] ACT-451840 (53) was discovered in a phenotypic screening and showed dual activity against asexual and sexual stages of P. falciparum and P. vivax, showing good gametocidal activity, fast action, and longer half-life than artemisinin. [179,180] The exposure of 53 is increased fourteen times in the presence of fatty and caloric foods.…”

Section: Antimalarial Candidates In Phase IIImentioning

confidence: 99%

Antiprotozoal agents: How have they changed over a decade?

Fernandes

Rosa

Zimmermann

et al. 2021

Archiv der Pharmazie

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Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low‐ or low‐to‐middle‐income countries located in tropical and subtropical zones. The number and availability of drugs for treating these diseases are low, the administration route is inconvenient in some cases, and most of them have safety, efficacy, or adverse/toxic reaction issues. The need for developing new drugs to deal with these issues is clear, but one of the most drastic consequences of this negligence is the lack of interest in the research and development of new therapeutic options among major pharmaceutical companies. Positive changes have been achieved over the last few years, although the overall situation remains alarming. After more than one decade since the original work reviewing antiprotozoal agents came to light, now it is time to question ourselves: How has the scenario for the treatment of protozoal diseases such as malaria, leishmaniasis, human African trypanosomiasis, and American trypanosomiasis changed? This review covers the last decade in terms of the drugs currently available for the treatment of these diseases as well as the clinical candidates being currently investigated.

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“…SC83288 (an amicarbalide derivative) is the only agent in preclinical investigation that are going to treat sever malaria [208]. It is also possible to list Genz-668764, ML238, ACT-213615, and TDR84420 within the new chemical entity group [209].…”

Section: Drugs In the Pipelinementioning

confidence: 99%

Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia

Nureye

Assefa

2020

The Scientific World Journal

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Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major public health threat in many countries. This article aims to present different aspects of malaria including causes, pathogenesis, prevention, and treatment in an articulate and comprehensive manner. Six Plasmodium species are recognized as the etiology of human malaria, of which Plasmodium falciparum is popular in East and Southern Africa. Malaria is transmitted mainly through Anopheles gambiae and Anopheles funestus, the two most effective malaria vectors in the world. Half of the world’s population is at risk for malaria infection. Globally, the morbidity and mortality rates of malaria have become decreased even though few reports in Ethiopia showed high prevalence of malaria. The malaria parasite has a complex life cycle that takes place both inside the mosquito and human beings. Generally, diagnosis of malaria is classified into clinical and parasitological diagnoses. Lack of clear understanding on the overall biology of Plasmodium has created a challenge in an effort to develop new drugs, vaccines, and preventive methods against malaria. However, three types of vaccines and a lot of novel compounds are under perclinical and clinical studies that are triggered by the occurrence of resistance among commonly used drugs and insecticides. Antiadhesion adjunctive therapies are also under investigation in the laboratory. In addition to previously known targets for diagnostic tool, vaccine and drug discovery scientists from all corner of the world are in search of new targets and chemical entities.

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Antimalaria Drug Development & Pipeline

Cited by 5 publications

References 23 publications

COVID-19 mitigation: nanotechnological intervention, perspective, and future scope

COVID-19 mitigation: nanotechnological intervention, perspective, and future scope

Antiprotozoal agents: How have they changed over a decade?

Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia

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