Antimalaria activity of ethanolic extracts of leaves of &lt;i&gt;Terminalia catappa&lt;/i&gt;. L. Combretaceae (indian almond)

Mudi, SY; Muhammad, Ali

doi:10.4314/bajopas.v2i1.58449

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Several species including T. mollis (Maregesi et al 2010), T. catappa (Mudi and Muhammad 2009), T. chebula and T. bellerica (Pinmai et al 2010) have been reported to have activity against Plasmodium falciparum. Terminalia avicennoides (Alayande et al 2011) and T. ivorensis (Agbedahunsi et al 2006) have been reported to have inhibitory activity towards Trypanosomiasis brucei (the parasite responsible for sleeping sickness).…”

Section: Antimicrobial Activitymentioning

confidence: 97%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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Plants of the genus Terminalia are amongst the most widely used plants for traditional medicinal purposes worldwide. Many species are used for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, antiinflammatory and anticancer activities. Wound healing and cardiovascular effects have also been credited to some species. Many Terminalia species have multiple beneficial effects for multiple diseases and ailments. Indeed, the Indian species Terminalia chebula is known as the king of plants in Ayurveda due to its broad range of medicinal uses. However, apart from the reported ethnopharmacological uses of many Terminalia species, surprisingly few studies have rigorously examined this important genus for their medical properties/mechanisms and phytochemistry. This is likely due to the high tannin content common to many Terminalia species and the perception that these tannins may be responsible for much of their beneficial properties. As the complexities of tannins make them poor candidates for drug design, most interest in Terminalia species has been for their pharmacognostic and nutraceutical value and they have often been overlooked as potentials for drug discovery. However, recent reports have identified many other interesting phytochemicals and demonstrated that these may be responsible for several of the reported bioactivities of the Terminalia species used in traditional medicinal systems. The last decade has seen a large increase in the number of studies into the use of Terminalia species as therapeutic agents. Several species used in Ayurvedic medicine (Terminalia arjuna, Terminalia bellerica, Terminalia catappa, T. chebula) in particular have received much recent attention. Similarly, recent reports have also highlighted the medicinal potential of species from Africa, Australia and the Americas. The aim of this report is to summarise the recent research into the medicinal properties, phytochemistry and therapeutic mechanisms of Terminalia species and thus to highlight and direct future areas of research into the medicinal activities of this important genus.

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Section: Antimicrobial Activitymentioning

confidence: 97%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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“…catappa to treat dermatitis and pyresis [ 1 – 4 ]. Moreover, the antimicrobial and antifungal [ 5 – 8 ], antioxidative [ 9 – 11 ], anti-inflammatory [ 12 , 13 ], hepatoprotective [ 3 , 4 ], antidiabetic [ 14 ], carcinogenesis-preventing effects [ 15 – 17 ], antimalaric [ 18 ], and antinociceptive [ 19 ] of T. catappa could potentially provide benefits to human health.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity

Mininel

Leonardo

Espanha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Terminalia is a genus of Combretaceous plants widely distributed in tropical and subtropical regions. Thus, the aim of this study was to quantify the majority compounds of the hydroalcoholic extract (7 : 3, v/v) of the leaves from T. catappa by HPLC-PDA, chemically characterize by hyphenated techniques (HPLC-ESI-IT-MSn) and NMR, and evaluate its mutagenic activity by the Salmonella/microsome assay on S. typhimurium strains TA98, TA97a, TA100, and TA102. The quantification of analytes was performed using an external calibration standard. Punicalagin is the most abundant polyphenol found in the leaves. The presence of this compound as a mixture of anomers was confirmed using HPLC-PDA and 1H and 13C NMR. Mutagenic activity was observed in strains TA100 and TA97a. As the extract is a complex mixture of punicalagin, its derivatives, and several other compounds, the observed mutagenicity may be explained in part by possible synergistic interaction between the compounds present in the extract. These studies show that mutagenic activity of T. catappa in the Ames test can only be observed when measured at high concentrations. However, considering the mutagenic effects observed for T. catappa, this plant should be used cautiously for medicinal purposes.

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“…However, the highest crude lipid 13.5% in roots and 12.5% in leaves was recorded. According to [25], a moderate amount of lipid has health benefits in the body. The high crude fibre content in the root(41.8%) for K and 35.5% for P recorded in Arctium lappa L. suggests it can be a potential source of dietary fibre for anti-tumorigenic and hypocholestrolemic properties [26].…”

Section: Phytochemical Screening Of Root and Leaf Extracts Of Arctium Lappa Lmentioning

confidence: 99%

Growth, Yield and Phytochemical Constituents of Arctium lappa L. in Response to Phosphorous and Potassium Fertilizers Application

2020

SETWM-20, ACBES-20 &Amp; EEHSS-20 Nov. 16-17, 2020 Johannesburg (SA)

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Burdock (Arctium lappa L), is a medicinal plant with many therapeutic values but its cultivation practice is given less attention causing pressure on its wild population. A two separate complete randomized design pot experiment with five treatments of phosphorous (Triple superphosphate 20%) at five levels (140, 210, 280, 350 and 420 kg/ha) and potassium (Potassium Chloride 50%) at five levels (210, 315, 420, 520 and 630Kg/ha) with a basal application of Nitrogen fertilizer (Urea,160 Kg/ha) replicated four times was conducted. Fertilizer treatments were split into two equal doses at seedling transplant and four weeks after transplant. Data on growth and yield were collected and analyzed using SAS software. Test results were significant (p<0.05) in growth parameters in response to phosphorous and the number of leaves in potassium treatments. However, there was no significant difference (p>0.05) on yield parameters due to fertilizer application except for root length. Phytochemical screening indicates the presence of Tannins, flavonoids, Terpenoids, glycosides, and phenols across treatments. Crude lipid and ash content were not significant (p>0.05) but there was a significant difference (p<0.05) on crude fibre content in response to fertilizer treatments.n.

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Antimalaria activity of ethanolic extracts of leaves of <i>Terminalia catappa</i>. L. Combretaceae (indian almond)

Cited by 5 publications

References 6 publications

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity

Growth, Yield and Phytochemical Constituents of Arctium lappa L. in Response to Phosphorous and Potassium Fertilizers Application

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