Antileishmanial screening, physicochemical properties and drug likeness of pyrazole carbaldehyde derivatives

Alodeani, Essa Ajmi; Izhari, Mohammad Asrar; Arshad, Mohammad

doi:10.21276/apjhs.2015.2.2.8

Cited by 12 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Signals for the carbon atoms attached to the etheric oxygen atom ( 7 C–O–C 12 ) were seen at 153.83 and 111.82 ppm, respectively. [ 28 ] The chemical shift for the azomethine carbon atom ( 17 C=N) was seen at 138.99 ppm. The other quinolin‐8‐yloxy carbon atoms ( 1 C, 2 C, 4 C, 5 C, 6 C, 7 C, 8 C, 9 C, and 10 C)‐were observed at 122.34, 148.65, 136.58, 128.02, 132.67, 116.02, 127.89, and 118.24 ppm, respectively, consistent with Alodeani et al .…”

Section: Resultsmentioning

confidence: 99%

“…The other quinolin‐8‐yloxy carbon atoms ( 1 C, 2 C, 4 C, 5 C, 6 C, 7 C, 8 C, 9 C, and 10 C)‐were observed at 122.34, 148.65, 136.58, 128.02, 132.67, 116.02, 127.89, and 118.24 ppm, respectively, consistent with Alodeani et al . [ 28 ] The aromatic carbons of the phenyl moiety were seen at 129.32, 132.59, and 116.21 ppm.…”

Section: Resultsmentioning

confidence: 99%

“…The 13 C NMR spectrum of hydrazone 1 (Figure 4) has two consecutive singlets at 166.94 and 166.43 ppm, which could be ascribed to the carbon atoms of the ketonic and enolic carbonyl groups ( 13 C=O and for the carbon atoms attached to the etheric oxygen atom ( 7 C-O-C 12 ) were seen at 153.83 and 111.82 ppm, respectively. [28] The chemical shift for the azomethine carbon atom ( 17 C=N) was seen at 138.99 ppm. The other quinolin-8-yloxy carbon atoms ( 1 C, 2 C, 4 C, 5 C, 6 C, 7 C, 8 C, 9 C, and 10 C)-were observed at 122.…”

Section: Biocidal Activitiesmentioning

confidence: 99%

See 2 more Smart Citations

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

El‐Saied

Shakdofa

Al‐Hakimi

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

complexes of a synthetic novel hydrazone containing a quinoline moiety were prepared. The composition and structure of the prepared compounds were elucidated by spectral and analytical techniques. The results reveal that all complexes were formed in 1:1 mole ratio except Mn 2+ and Cu 2+ complexes (3) and (7), which were formed in 1 M:2 L mole ratio. It was also found that the ligand binds the metal ions via NO donor sites as a monobasic bidentate chelator in all complexes through the enolic carbonyl oxygen and azomethine nitrogen atoms. The electronic absorption spectra and magnetic moment data demonstrated square pyramidal and octahedral geometries for the VO 2+ and Ni 2+ complexes, respectively, while the other complexes adopted tetrahedral geometry. The thermal decomposition of the complexes was discussed in relation to structure. The thermal analysis data demonstrated that all complexes were decomposed in one, two, three or four stages starting with the dehydration process, removal of coordination water molecules or elimination of anions and ended with the formation of the metal oxide. The bactericidal activities of the prepared compounds demonstrated that hydrazone (1) exerted a highly inhibitory effect against B. subtilis while VO 2+ , Co 2+ , and Cu 2+ complexes (2), (4), and (7) showed an inhibitory effect against E. coli more than the tetracycline. Additionally, the inhibitory effect of the prepared compound against A. niger showed that the Cu 2+ complex (6) is the most active while the Ni 2+ , Cu 2+ , and Zn 2+ complexes (5-8) exhibited an extremely inhibitory effect against C. albicans.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Biocidal Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

El‐Saied

Shakdofa

Al‐Hakimi

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…Condensed pyrimidine derivatives have also been reported as antimicrobial and hypnotic drugs for the nervous system, with activities including anti‐inflammatory, anti‐HIV, antiparasitic, and antitumor and have been used as calcium‐sensing receptor antagonists, antiulceratives, and antimalarial agents. They are also used as cardiovascular agents and diuretic drugs …”

Section: Introductionmentioning

confidence: 99%

Selective cyclization of S‐substituted pyrimidinethione: Synthesis and antimicrobial evaluation of novel polysubstituted thiazolopyrimidine and thiazolodipyrimidine derivatives

Alzahrani

Fouda

Youssef

2019

J Chinese Chemical Soc

View full text Add to dashboard Cite

The synthetic strategy is based on alkylation of 4-aryl-N-(4-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives IV a-g, with some alkyl halides and α-haloketones, namely, methyl iodide, chloroacetonitrile, and phenacyl bromide to give the corresponding S-substituted derivatives Va-c. Treatment of IVa-c with ethyl bromoacetate in ethanol under reflux in the presence of potassium hydroxide solution led to the forma-On the other hand, compound IVa reacted with α-halo carbonitriles, namely, chloro acetonitrile, and monobromo malononitrile, to produce directly thiazolo[3,2-a]pyrimidine derivatives Xa and Xb, respectively, Compound Xb also reacted with each of formic acid, formamide, and ammonium thiocyanate to form thiazolodipyrimidine derivatives XI-XIII, respectively. Compound VIIIa-c coupled with arenediazonium salts in pyridine to give the corresponding 2-arylhydrazo derivatives XVIa-e. Compounds IV a-g and VIIIa-c were resynthesized under microwave irradiation. Some of the newly synthesized compounds were tested for their antimicrobial activities.

show abstract

“…Despite the major role that 1‐H pyrazole based molecules play in traditional inorganic chemistry, biomolecules and drugs, it is surprising that gelation properties of 1‐H pyrazole derivatives is unexplored to date, except a very few random examples of metallogelation . 1‐H pyrazole ring possesses a rich supramolecular chemistry and can offer a broad scope of study on hydrogen bonding along with metal coordination.…”

Section: Introductionmentioning

confidence: 99%

Gel–based Controlled Synthesis of Silver Nanoparticles and Their Applications in Catalysis, Sensing and Environmental Remediation

Bala

Mondal

2017

ChemistrySelect

View full text Add to dashboard Cite

We report herein a novel gel-based method of generating silver nanoparticles (AgNPs) for various applications. An unorthodox pyridyl-pyrazole basedchelatinglow molecular mass gelator was used for controlled synthesis of multifunctional AgNPs. The resultant fiber networks of gel itself act as template for AgNPs formation when a threshold concentration of Ag salts is exceeded. It is noteworthy here that existence of such threshold condition for AgNP formation is strategically important but under explored. The as-synthesized AgNPs exhibit efficient catalytic activity of the reduction of 4-nitrophenol and Methylene blue.The as-synthesized AgNPs shows highly selective sensing ability of toxic Hg 2 + ion in ppm level. Furthermore, our system also offers a unique two-in-one environmental remediation through sequestration-cum-reduction of toxic hexavalent Cr.[a] Dr.

show abstract

Antileishmanial screening, physicochemical properties and drug likeness of pyrazole carbaldehyde derivatives

Cited by 12 publications

References 0 publications

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

Selective cyclization of S‐substituted pyrimidinethione: Synthesis and antimicrobial evaluation of novel polysubstituted thiazolopyrimidine and thiazolodipyrimidine derivatives

Gel–based Controlled Synthesis of Silver Nanoparticles and Their Applications in Catalysis, Sensing and Environmental Remediation

Contact Info

Product

Resources

About